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High prevalence of carbapenem-resistant Enterobacterales (CRE) in human samples from Nigeria: A systematic review and meta-analysis

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Title: High prevalence of carbapenem-resistant Enterobacterales (CRE) in human samples from Nigeria: A systematic review and meta-analysis
Authors: Ahmad Adebayo Irekeola, Rafidah Hanim Shueb, Engku Nur Syafirah Engku Abd Rahman, Hafeez Abiola Afolabi, Yusuf Wada, Abdirahman Hussein Elmi, Muath Abdu Hakami, Sfeeah Mofareah Alghzwani, Osman AE. Elnoubi, Ahmad A. Alshehri
Source: Heliyon, Vol 10, Iss 15, Pp e34926- (2024)
Publisher Information: Elsevier, 2024.
Publication Year: 2024
Collection: LCC:Science (General)
LCC:Social sciences (General)
Subject Terms: Carbapenem, Enterobacterales, Resistance, Nigeria, Science (General), Q1-390, Social sciences (General), H1-99
More Details: Objectives: The rise in Carbapenem-resistant Enterobacterales (CRE) is perturbing. To curb the menace of CRE, a comprehensive understanding of its prevalence and epidemiology is crucial. As varying reports abound, the true prevalence of CRE in Nigeria remains unknown. Here, we conducted a systematic review and meta-analysis following standard guidelines to assess the situation of CRE in Nigeria. Methods: We searched electronic databases including Pubmed, ScienceDirect, Scopus, Web of Science, and Google Scholar for articles providing information on CRE in Nigeria. The data gathered were analyzed using OpenMeta Analyst and Comprehensive Meta-Analysis software. The random-effect model was employed to calculate pooled resistance to carbapenem antibiotics. Results: From 321 retrieved records, 57 were finally included. The studies were predominantly from the South-West region (n = 19). Escherichia coli and Klebsiella pneumoniae were the most frequently tested Enterobacterales among the included studies. The pooled prevalence estimate for imipenem resistance among CRE was 11.2 % (95 % CI: 7.9–15.7). Meropenem resistance had an estimate of 13.5 % (95 % CI: 9.1–19.6), whereas ertapenem and doripenem were estimated at 17.0 % (95 % CI: 9.9–27.7) and 37.9 % (95 % CI: 15.0–67.8), respectively. High heterogeneity (I2>85 %, p
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2405-8440
Relation: http://www.sciencedirect.com/science/article/pii/S2405844024109577; https://doaj.org/toc/2405-8440
DOI: 10.1016/j.heliyon.2024.e34926
Access URL: https://doaj.org/article/c1d4d7ebd97440b5b9246571bbec35d2
Accession Number: edsdoj.1d4d7ebd97440b5b9246571bbec35d2
Database: Directory of Open Access Journals
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  Data: <searchLink fieldCode="AR" term="%22Ahmad+Adebayo+Irekeola%22">Ahmad Adebayo Irekeola</searchLink><br /><searchLink fieldCode="AR" term="%22Rafidah+Hanim+Shueb%22">Rafidah Hanim Shueb</searchLink><br /><searchLink fieldCode="AR" term="%22Engku+Nur+Syafirah+Engku+Abd+Rahman%22">Engku Nur Syafirah Engku Abd Rahman</searchLink><br /><searchLink fieldCode="AR" term="%22Hafeez+Abiola+Afolabi%22">Hafeez Abiola Afolabi</searchLink><br /><searchLink fieldCode="AR" term="%22Yusuf+Wada%22">Yusuf Wada</searchLink><br /><searchLink fieldCode="AR" term="%22Abdirahman+Hussein+Elmi%22">Abdirahman Hussein Elmi</searchLink><br /><searchLink fieldCode="AR" term="%22Muath+Abdu+Hakami%22">Muath Abdu Hakami</searchLink><br /><searchLink fieldCode="AR" term="%22Sfeeah+Mofareah+Alghzwani%22">Sfeeah Mofareah Alghzwani</searchLink><br /><searchLink fieldCode="AR" term="%22Osman+AE%2E+Elnoubi%22">Osman AE. Elnoubi</searchLink><br /><searchLink fieldCode="AR" term="%22Ahmad+A%2E+Alshehri%22">Ahmad A. Alshehri</searchLink>
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  Data: Objectives: The rise in Carbapenem-resistant Enterobacterales (CRE) is perturbing. To curb the menace of CRE, a comprehensive understanding of its prevalence and epidemiology is crucial. As varying reports abound, the true prevalence of CRE in Nigeria remains unknown. Here, we conducted a systematic review and meta-analysis following standard guidelines to assess the situation of CRE in Nigeria. Methods: We searched electronic databases including Pubmed, ScienceDirect, Scopus, Web of Science, and Google Scholar for articles providing information on CRE in Nigeria. The data gathered were analyzed using OpenMeta Analyst and Comprehensive Meta-Analysis software. The random-effect model was employed to calculate pooled resistance to carbapenem antibiotics. Results: From 321 retrieved records, 57 were finally included. The studies were predominantly from the South-West region (n = 19). Escherichia coli and Klebsiella pneumoniae were the most frequently tested Enterobacterales among the included studies. The pooled prevalence estimate for imipenem resistance among CRE was 11.2 % (95 % CI: 7.9–15.7). Meropenem resistance had an estimate of 13.5 % (95 % CI: 9.1–19.6), whereas ertapenem and doripenem were estimated at 17.0 % (95 % CI: 9.9–27.7) and 37.9 % (95 % CI: 15.0–67.8), respectively. High heterogeneity (I2>85 %, p
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    Subjects:
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        Type: general
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      – SubjectFull: Resistance
        Type: general
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