Academic Journal
View in EDS
PDF Full Text

Recurrent Glioblastomas Reveal Molecular Subtypes Associated with Mechanistic Implications of Drug-Resistance.

Bibliographic Details
Title: Recurrent Glioblastomas Reveal Molecular Subtypes Associated with Mechanistic Implications of Drug-Resistance.
Authors: So Mee Kwon, Shin-Hyuk Kang, Chul-Kee Park, Shin Jung, Eun Sung Park, Ju-Seog Lee, Se-Hyuk Kim, Hyun Goo Woo
Source: PLoS ONE, Vol 10, Iss 10, p e0140528 (2015)
Publisher Information: Public Library of Science (PLoS), 2015.
Publication Year: 2015
Collection: LCC:Medicine
LCC:Science
Subject Terms: Medicine, Science
More Details: Previously, transcriptomic profiling studies have shown distinct molecular subtypes of glioblastomas. It has also been suggested that the recurrence of glioblastomas could be achieved by transcriptomic reprograming of tumors, however, their characteristics are not yet fully understood. Here, to gain the mechanistic insights on the molecular phenotypes of recurrent glioblastomas, gene expression profiling was performed on the 43 cases of glioblastomas including 15 paired primary and recurrent cases. Unsupervised clustering analyses revealed two subtypes of G1 and G2, which were characterized by proliferation and neuron-like gene expression traits, respectively. While the primary tumors were classified as G1 subtype, the recurrent glioblastomas showed two distinct expression types. Compared to paired primary tumors, the recurrent tumors in G1 subtype did not show expression alteration. By contrast, the recurrent tumors in G2 subtype showed expression changes from proliferation type to neuron-like one. We also observed the expression of stemness-related genes in G1 recurrent tumors and the altered expression of DNA-repair genes (i.e., AURK, HOX, MGMT, and MSH6) in the G2 recurrent tumors, which might be responsible for the acquisition of drug resistance mechanism during tumor recurrence in a subtype-specific manner. We suggest that recurrent glioblastomas may choose two different strategies for transcriptomic reprograming to escape the chemotherapeutic treatment during tumor recurrence. Our results might be helpful to determine personalized therapeutic strategy against heterogeneous glioma recurrence.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1932-6203
Relation: http://europepmc.org/articles/PMC4605710?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0140528
Access URL: https://doaj.org/article/13b0c4e39eb943d3b5dc0c652f9e3ecc
Accession Number: edsdoj.13b0c4e39eb943d3b5dc0c652f9e3ecc
Database: Directory of Open Access Journals
FullText Links:
  – Type: pdflink
    Url: https://content.ebscohost.com/cds/retrieve?content=AQICAHjPtM4BHU3ZchRwgzYmadcigk49r9CVlbU7V5F6lgH7WwGulnQ1QenhWCnfK4CvQ7YFAAAA4jCB3wYJKoZIhvcNAQcGoIHRMIHOAgEAMIHIBgkqhkiG9w0BBwEwHgYJYIZIAWUDBAEuMBEEDN8hHoq-u-YpyZHJgAIBEICBmh0UqAfsGtIKIOVRGJGjDbfbVcbThDbviSm6PPh2g1f5WdTH8-d_9fGaaCyVek687Nv1kujskiY4elvzXb89v91pF9ZKh8gNekGV2gvnbNhaXWln274AzjuO5zk3JgCRgea2lMvdMqyheTa3rIYzAXh4Yx-8fTCd9mwbVcdZ8bVToCboxl9z44UeXw3xQOM4fhv99ad7lR0B6XQ=
Text:
  Availability: 0
CustomLinks:
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edsdoj&genre=article&issn=19326203&ISBN=&volume=10&issue=10&date=20150101&spage=e0140528&pages=&title=PLoS ONE&atitle=Recurrent%20Glioblastomas%20Reveal%20Molecular%20Subtypes%20Associated%20with%20Mechanistic%20Implications%20of%20Drug-Resistance.&aulast=So%20Mee%20Kwon&id=DOI:10.1371/journal.pone.0140528
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
  – Url: https://doaj.org/article/13b0c4e39eb943d3b5dc0c652f9e3ecc
    Name: EDS - DOAJ (s8985755)
    Category: fullText
    Text: View record from DOAJ
    MouseOverText: View record from DOAJ
Header DbId: edsdoj
DbLabel: Directory of Open Access Journals
An: edsdoj.13b0c4e39eb943d3b5dc0c652f9e3ecc
RelevancyScore: 856
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 855.848266601563
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Recurrent Glioblastomas Reveal Molecular Subtypes Associated with Mechanistic Implications of Drug-Resistance.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22So+Mee+Kwon%22">So Mee Kwon</searchLink><br /><searchLink fieldCode="AR" term="%22Shin-Hyuk+Kang%22">Shin-Hyuk Kang</searchLink><br /><searchLink fieldCode="AR" term="%22Chul-Kee+Park%22">Chul-Kee Park</searchLink><br /><searchLink fieldCode="AR" term="%22Shin+Jung%22">Shin Jung</searchLink><br /><searchLink fieldCode="AR" term="%22Eun+Sung+Park%22">Eun Sung Park</searchLink><br /><searchLink fieldCode="AR" term="%22Ju-Seog+Lee%22">Ju-Seog Lee</searchLink><br /><searchLink fieldCode="AR" term="%22Se-Hyuk+Kim%22">Se-Hyuk Kim</searchLink><br /><searchLink fieldCode="AR" term="%22Hyun+Goo+Woo%22">Hyun Goo Woo</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: PLoS ONE, Vol 10, Iss 10, p e0140528 (2015)
– Name: Publisher
  Label: Publisher Information
  Group: PubInfo
  Data: Public Library of Science (PLoS), 2015.
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2015
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: LCC:Medicine<br />LCC:Science
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Medicine%22">Medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Science%22">Science</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Previously, transcriptomic profiling studies have shown distinct molecular subtypes of glioblastomas. It has also been suggested that the recurrence of glioblastomas could be achieved by transcriptomic reprograming of tumors, however, their characteristics are not yet fully understood. Here, to gain the mechanistic insights on the molecular phenotypes of recurrent glioblastomas, gene expression profiling was performed on the 43 cases of glioblastomas including 15 paired primary and recurrent cases. Unsupervised clustering analyses revealed two subtypes of G1 and G2, which were characterized by proliferation and neuron-like gene expression traits, respectively. While the primary tumors were classified as G1 subtype, the recurrent glioblastomas showed two distinct expression types. Compared to paired primary tumors, the recurrent tumors in G1 subtype did not show expression alteration. By contrast, the recurrent tumors in G2 subtype showed expression changes from proliferation type to neuron-like one. We also observed the expression of stemness-related genes in G1 recurrent tumors and the altered expression of DNA-repair genes (i.e., AURK, HOX, MGMT, and MSH6) in the G2 recurrent tumors, which might be responsible for the acquisition of drug resistance mechanism during tumor recurrence in a subtype-specific manner. We suggest that recurrent glioblastomas may choose two different strategies for transcriptomic reprograming to escape the chemotherapeutic treatment during tumor recurrence. Our results might be helpful to determine personalized therapeutic strategy against heterogeneous glioma recurrence.
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: article
– Name: Format
  Label: File Description
  Group: SrcInfo
  Data: electronic resource
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: ISSN
  Label: ISSN
  Group: ISSN
  Data: 1932-6203
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: http://europepmc.org/articles/PMC4605710?pdf=render; https://doaj.org/toc/1932-6203
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1371/journal.pone.0140528
– Name: URL
  Label: Access URL
  Group: URL
  Data: <link linkTarget="URL" linkTerm="https://doaj.org/article/13b0c4e39eb943d3b5dc0c652f9e3ecc" linkWindow="_blank">https://doaj.org/article/13b0c4e39eb943d3b5dc0c652f9e3ecc</link>
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsdoj.13b0c4e39eb943d3b5dc0c652f9e3ecc
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsdoj&AN=edsdoj.13b0c4e39eb943d3b5dc0c652f9e3ecc
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1371/journal.pone.0140528
    Languages:
      – Text: English
    PhysicalDescription:
      Pagination:
        StartPage: e0140528
    Subjects:
      – SubjectFull: Medicine
        Type: general
      – SubjectFull: Science
        Type: general
    Titles:
      – TitleFull: Recurrent Glioblastomas Reveal Molecular Subtypes Associated with Mechanistic Implications of Drug-Resistance.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: So Mee Kwon
      – PersonEntity:
          Name:
            NameFull: Shin-Hyuk Kang
      – PersonEntity:
          Name:
            NameFull: Chul-Kee Park
      – PersonEntity:
          Name:
            NameFull: Shin Jung
      – PersonEntity:
          Name:
            NameFull: Eun Sung Park
      – PersonEntity:
          Name:
            NameFull: Ju-Seog Lee
      – PersonEntity:
          Name:
            NameFull: Se-Hyuk Kim
      – PersonEntity:
          Name:
            NameFull: Hyun Goo Woo
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Type: published
              Y: 2015
          Identifiers:
            – Type: issn-print
              Value: 19326203
          Numbering:
            – Type: volume
              Value: 10
            – Type: issue
              Value: 10
          Titles:
            – TitleFull: PLoS ONE
              Type: main
ResultId 1