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Antibacterial activities of Origanum vulgare alone and in combination with different antimicrobials against clinical isolates of Salmonella typhi

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Title: Antibacterial activities of Origanum vulgare alone and in combination with different antimicrobials against clinical isolates of Salmonella typhi
Authors: Veni Bharti, Neeru Vasudeva, Sunil Sharma, Joginder Singh Duhan
Source: Ancient Science of Life, Vol 32, Iss 4, Pp 212-216 (2013)
Publisher Information: Wolters Kluwer Medknow Publications, 2013.
Publication Year: 2013
Collection: LCC:Medicine
Subject Terms: Antimicrobial resistance, fractional inhibitory concentration, minimum inhibitory concentration, multidrug resistance, Salmonella typhi, Medicine
More Details: Background: Typhoid fever continues to remain a major public health problem especially in the areas where there is problem of sanitation and hygiene. The emergence of multidrug resistance of Salmonella typhi, the bacteria responsible for Typhoid to ampicillin, chloramphenicol, and cotrimoxazole has further complicated the treatment and management of enteric fever. One strategy for the treatment of the multidrug resistant bacteria is to use herbs in combination with conventional drugs. The present study was done to find out the interaction effect of phenolic, nonphenolic fractions, and volatile oil of Origanum vulgare with ciprofloxacin. Materials and Methods: The minimum inhibitory concentration (MIC) by microdilution method for individual phytoconstituents and in combination with ciprofloxacin was compared for clinically isolated bacteria from patients infected with S. typhi. Fractional inhibitory concentration (FIC) and Fractional inhibitory concentration index (FICI) were also calculated. Results: The MIC declined to a significant level indicating synergistic relationship between ciprofloxacin and phenolic, nonphenolic fractions and volatile oil in vitro. The FICI exhibits synergistic effect for all the three samples while indifferent and antagonistic for samples and for phenolic and nonphenolic fractions. Conclusions: Present study shows that not only the formulation using O. vulgare and ciprofloxacin can overcome multidrug resistance but also will reduce the toxic effects of ciprofloxacin.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 0257-7941
Relation: http://www.ancientscienceoflife.org/article.asp?issn=0257-7941;year=2013;volume=32;issue=4;spage=212;epage=216;aulast=Bharti; https://doaj.org/toc/0257-7941
DOI: 10.4103/0257-7941.131974
Access URL: https://doaj.org/article/d12aa2d5ddf640308fd39560319182d9
Accession Number: edsdoj.12aa2d5ddf640308fd39560319182d9
Database: Directory of Open Access Journals
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  Data: Antibacterial activities of Origanum vulgare alone and in combination with different antimicrobials against clinical isolates of Salmonella typhi
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  Data: Ancient Science of Life, Vol 32, Iss 4, Pp 212-216 (2013)
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  Data: Wolters Kluwer Medknow Publications, 2013.
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  Data: <searchLink fieldCode="DE" term="%22Antimicrobial+resistance%22">Antimicrobial resistance</searchLink><br /><searchLink fieldCode="DE" term="%22fractional+inhibitory+concentration%22">fractional inhibitory concentration</searchLink><br /><searchLink fieldCode="DE" term="%22minimum+inhibitory+concentration%22">minimum inhibitory concentration</searchLink><br /><searchLink fieldCode="DE" term="%22multidrug+resistance%22">multidrug resistance</searchLink><br /><searchLink fieldCode="DE" term="%22Salmonella+typhi%22">Salmonella typhi</searchLink><br /><searchLink fieldCode="DE" term="%22Medicine%22">Medicine</searchLink>
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  Data: Background: Typhoid fever continues to remain a major public health problem especially in the areas where there is problem of sanitation and hygiene. The emergence of multidrug resistance of Salmonella typhi, the bacteria responsible for Typhoid to ampicillin, chloramphenicol, and cotrimoxazole has further complicated the treatment and management of enteric fever. One strategy for the treatment of the multidrug resistant bacteria is to use herbs in combination with conventional drugs. The present study was done to find out the interaction effect of phenolic, nonphenolic fractions, and volatile oil of Origanum vulgare with ciprofloxacin. Materials and Methods: The minimum inhibitory concentration (MIC) by microdilution method for individual phytoconstituents and in combination with ciprofloxacin was compared for clinically isolated bacteria from patients infected with S. typhi. Fractional inhibitory concentration (FIC) and Fractional inhibitory concentration index (FICI) were also calculated. Results: The MIC declined to a significant level indicating synergistic relationship between ciprofloxacin and phenolic, nonphenolic fractions and volatile oil in vitro. The FICI exhibits synergistic effect for all the three samples while indifferent and antagonistic for samples and for phenolic and nonphenolic fractions. Conclusions: Present study shows that not only the formulation using O. vulgare and ciprofloxacin can overcome multidrug resistance but also will reduce the toxic effects of ciprofloxacin.
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  Data: http://www.ancientscienceoflife.org/article.asp?issn=0257-7941;year=2013;volume=32;issue=4;spage=212;epage=216;aulast=Bharti; https://doaj.org/toc/0257-7941
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      – SubjectFull: fractional inhibitory concentration
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