Academic Journal
View in EDS

Electroacupuncture attenuates surgical pain-induced delirium-like behavior in mice via remodeling gut microbiota and dendritic spine

Bibliographic Details
Title: Electroacupuncture attenuates surgical pain-induced delirium-like behavior in mice via remodeling gut microbiota and dendritic spine
Authors: Liuyue Yang, Weihua Ding, Yuanlin Dong, Cynthia Chen, Yanru Zeng, Zhangjie Jiang, Shuyuan Gan, Zerong You, Yilin Zhao, Yiying Zhang, Xinghua Ren, Shiyu Wang, Jiajia Dai, Zhong Chen, Shengmei Zhu, Lucy Chen, Shiqian Shen, Jianren Mao, Zhongcong Xie
Source: Frontiers in Immunology, Vol 13 (2022)
Publisher Information: Frontiers Media S.A., 2022.
Publication Year: 2022
Collection: LCC:Immunologic diseases. Allergy
Subject Terms: surgical pain, delirium, gut microbiota, dendritic spine, microglia, electroacupuncture, Immunologic diseases. Allergy, RC581-607
More Details: Surgical pain is associated with delirium in patients, and acupuncture can treat pain. However, whether electroacupuncture can attenuate the surgical pain-associated delirium via the gut–brain axis remains unknown. Leveraging a mouse model of foot incision-induced surgical pain and delirium-like behavior, we found that electroacupuncture stimulation at specific acupoints (e.g., DU20+KI1) attenuated both surgical pain and delirium-like behavior in mice. Mechanistically, mice with incision-induced surgical pain and delirium-like behavior showed gut microbiota imbalance, microglia activation in the spinal cord, somatosensory cortex, and hippocampus, as well as an enhanced dendritic spine elimination in cortex revealed by two-photon imaging. The electroacupuncture regimen that alleviated surgical pain and delirium-like behavior in mice also effectively restored the gut microbiota balance, prevented the microglia activation, and reversed the dendritic spine elimination. These data demonstrated a potentially important gut–brain interactive mechanism underlying the surgical pain-induced delirium in mice. Pending further studies, these findings revealed a possible therapeutic approach in preventing and/or treating postoperative delirium by using perioperative electroacupuncture stimulation in patients.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1664-3224
Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.955581/full; https://doaj.org/toc/1664-3224
DOI: 10.3389/fimmu.2022.955581
Access URL: https://doaj.org/article/0a9d0d31e4fd45c2a44a5995063b61fa
Accession Number: edsdoj.0a9d0d31e4fd45c2a44a5995063b61fa
Database: Directory of Open Access Journals
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edsdoj&genre=article&issn=16643224&ISBN=&volume=13&issue=&date=20220801&spage=&pages=&title=Frontiers in Immunology&atitle=Electroacupuncture%20attenuates%20surgical%20pain-induced%20delirium-like%20behavior%20in%20mice%20via%20remodeling%20gut%20microbiota%20and%20dendritic%20spine&aulast=Liuyue%20Yang&id=DOI:10.3389/fimmu.2022.955581
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
  – Url: https://doaj.org/article/0a9d0d31e4fd45c2a44a5995063b61fa
    Name: EDS - DOAJ (s8985755)
    Category: fullText
    Text: View record from DOAJ
    MouseOverText: View record from DOAJ
Header DbId: edsdoj
DbLabel: Directory of Open Access Journals
An: edsdoj.0a9d0d31e4fd45c2a44a5995063b61fa
RelevancyScore: 947
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 947.14111328125
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Electroacupuncture attenuates surgical pain-induced delirium-like behavior in mice via remodeling gut microbiota and dendritic spine
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Liuyue+Yang%22">Liuyue Yang</searchLink><br /><searchLink fieldCode="AR" term="%22Weihua+Ding%22">Weihua Ding</searchLink><br /><searchLink fieldCode="AR" term="%22Yuanlin+Dong%22">Yuanlin Dong</searchLink><br /><searchLink fieldCode="AR" term="%22Cynthia+Chen%22">Cynthia Chen</searchLink><br /><searchLink fieldCode="AR" term="%22Yanru+Zeng%22">Yanru Zeng</searchLink><br /><searchLink fieldCode="AR" term="%22Zhangjie+Jiang%22">Zhangjie Jiang</searchLink><br /><searchLink fieldCode="AR" term="%22Shuyuan+Gan%22">Shuyuan Gan</searchLink><br /><searchLink fieldCode="AR" term="%22Zerong+You%22">Zerong You</searchLink><br /><searchLink fieldCode="AR" term="%22Yilin+Zhao%22">Yilin Zhao</searchLink><br /><searchLink fieldCode="AR" term="%22Yiying+Zhang%22">Yiying Zhang</searchLink><br /><searchLink fieldCode="AR" term="%22Xinghua+Ren%22">Xinghua Ren</searchLink><br /><searchLink fieldCode="AR" term="%22Shiyu+Wang%22">Shiyu Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Jiajia+Dai%22">Jiajia Dai</searchLink><br /><searchLink fieldCode="AR" term="%22Zhong+Chen%22">Zhong Chen</searchLink><br /><searchLink fieldCode="AR" term="%22Shengmei+Zhu%22">Shengmei Zhu</searchLink><br /><searchLink fieldCode="AR" term="%22Lucy+Chen%22">Lucy Chen</searchLink><br /><searchLink fieldCode="AR" term="%22Shiqian+Shen%22">Shiqian Shen</searchLink><br /><searchLink fieldCode="AR" term="%22Jianren+Mao%22">Jianren Mao</searchLink><br /><searchLink fieldCode="AR" term="%22Zhongcong+Xie%22">Zhongcong Xie</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: Frontiers in Immunology, Vol 13 (2022)
– Name: Publisher
  Label: Publisher Information
  Group: PubInfo
  Data: Frontiers Media S.A., 2022.
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2022
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: LCC:Immunologic diseases. Allergy
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22surgical+pain%22">surgical pain</searchLink><br /><searchLink fieldCode="DE" term="%22delirium%22">delirium</searchLink><br /><searchLink fieldCode="DE" term="%22gut+microbiota%22">gut microbiota</searchLink><br /><searchLink fieldCode="DE" term="%22dendritic+spine%22">dendritic spine</searchLink><br /><searchLink fieldCode="DE" term="%22microglia%22">microglia</searchLink><br /><searchLink fieldCode="DE" term="%22electroacupuncture%22">electroacupuncture</searchLink><br /><searchLink fieldCode="DE" term="%22Immunologic+diseases%2E+Allergy%22">Immunologic diseases. Allergy</searchLink><br /><searchLink fieldCode="DE" term="%22RC581-607%22">RC581-607</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Surgical pain is associated with delirium in patients, and acupuncture can treat pain. However, whether electroacupuncture can attenuate the surgical pain-associated delirium via the gut–brain axis remains unknown. Leveraging a mouse model of foot incision-induced surgical pain and delirium-like behavior, we found that electroacupuncture stimulation at specific acupoints (e.g., DU20+KI1) attenuated both surgical pain and delirium-like behavior in mice. Mechanistically, mice with incision-induced surgical pain and delirium-like behavior showed gut microbiota imbalance, microglia activation in the spinal cord, somatosensory cortex, and hippocampus, as well as an enhanced dendritic spine elimination in cortex revealed by two-photon imaging. The electroacupuncture regimen that alleviated surgical pain and delirium-like behavior in mice also effectively restored the gut microbiota balance, prevented the microglia activation, and reversed the dendritic spine elimination. These data demonstrated a potentially important gut–brain interactive mechanism underlying the surgical pain-induced delirium in mice. Pending further studies, these findings revealed a possible therapeutic approach in preventing and/or treating postoperative delirium by using perioperative electroacupuncture stimulation in patients.
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: article
– Name: Format
  Label: File Description
  Group: SrcInfo
  Data: electronic resource
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: ISSN
  Label: ISSN
  Group: ISSN
  Data: 1664-3224
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: https://www.frontiersin.org/articles/10.3389/fimmu.2022.955581/full; https://doaj.org/toc/1664-3224
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.3389/fimmu.2022.955581
– Name: URL
  Label: Access URL
  Group: URL
  Data: <link linkTarget="URL" linkTerm="https://doaj.org/article/0a9d0d31e4fd45c2a44a5995063b61fa" linkWindow="_blank">https://doaj.org/article/0a9d0d31e4fd45c2a44a5995063b61fa</link>
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsdoj.0a9d0d31e4fd45c2a44a5995063b61fa
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsdoj&AN=edsdoj.0a9d0d31e4fd45c2a44a5995063b61fa
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.3389/fimmu.2022.955581
    Languages:
      – Text: English
    Subjects:
      – SubjectFull: surgical pain
        Type: general
      – SubjectFull: delirium
        Type: general
      – SubjectFull: gut microbiota
        Type: general
      – SubjectFull: dendritic spine
        Type: general
      – SubjectFull: microglia
        Type: general
      – SubjectFull: electroacupuncture
        Type: general
      – SubjectFull: Immunologic diseases. Allergy
        Type: general
      – SubjectFull: RC581-607
        Type: general
    Titles:
      – TitleFull: Electroacupuncture attenuates surgical pain-induced delirium-like behavior in mice via remodeling gut microbiota and dendritic spine
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Liuyue Yang
      – PersonEntity:
          Name:
            NameFull: Weihua Ding
      – PersonEntity:
          Name:
            NameFull: Yuanlin Dong
      – PersonEntity:
          Name:
            NameFull: Cynthia Chen
      – PersonEntity:
          Name:
            NameFull: Yanru Zeng
      – PersonEntity:
          Name:
            NameFull: Zhangjie Jiang
      – PersonEntity:
          Name:
            NameFull: Shuyuan Gan
      – PersonEntity:
          Name:
            NameFull: Zerong You
      – PersonEntity:
          Name:
            NameFull: Yilin Zhao
      – PersonEntity:
          Name:
            NameFull: Yiying Zhang
      – PersonEntity:
          Name:
            NameFull: Xinghua Ren
      – PersonEntity:
          Name:
            NameFull: Shiyu Wang
      – PersonEntity:
          Name:
            NameFull: Jiajia Dai
      – PersonEntity:
          Name:
            NameFull: Zhong Chen
      – PersonEntity:
          Name:
            NameFull: Shengmei Zhu
      – PersonEntity:
          Name:
            NameFull: Lucy Chen
      – PersonEntity:
          Name:
            NameFull: Shiqian Shen
      – PersonEntity:
          Name:
            NameFull: Jianren Mao
      – PersonEntity:
          Name:
            NameFull: Zhongcong Xie
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 08
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-print
              Value: 16643224
          Numbering:
            – Type: volume
              Value: 13
          Titles:
            – TitleFull: Frontiers in Immunology
              Type: main
ResultId 1