Academic Journal
View in EDS

Metabolically Healthy Obesity Is Associated with an Increased Risk of Colorectal Adenoma Occurrence Diagnosed by Surveillance Colonoscopy

Bibliographic Details
Title: Metabolically Healthy Obesity Is Associated with an Increased Risk of Colorectal Adenoma Occurrence Diagnosed by Surveillance Colonoscopy
Authors: Hyunbeom Chae, Hyo-Joon Yang, Soo-Kyung Park, Yoon Suk Jung, Jung Ho Park, Dong Il Park, Chong Il Sohn
Source: Gut and Liver, Vol 15, Iss 3, Pp 383-390 (2021)
Publisher Information: Gastroenterology Council for Gut and Liver, 2021.
Publication Year: 2021
Collection: LCC:Diseases of the digestive system. Gastroenterology
Subject Terms: colorectal neoplasm, recurrence, obesity, metabolically benign, cohort studies, colonoscopy, Diseases of the digestive system. Gastroenterology, RC799-869
More Details: Background/Aims: The risk of recurrence of colorectal adenoma among obese individuals without metabolic abnormalities or in those with metabolically healthy obesity is largely unexplored. Therefore, we longitudinally investigated the risk of adenoma occurrence in individuals undergoing surveillance colonoscopy according to metabolic status and obesity. Methods: This retrospective cohort study included 16,872 Korean adults who underwent their first screening colonoscopy between 2003 and 2012 and who then underwent follow-up colonoscopy until 2017. Participants were categorized into a metabolically healthy nonobese group (reference group), a metabolically healthy obese group, a metabolically abnormal nonobese group, and a metabolically abnormal obese group. Hazard ratios (HRs) for adenoma recurrence compared to the reference group were calculated in each group. Results: During a median follow-up duration of 47.3 months (interquartile range, 35.6 to 58.9 months), 3,673 (21.8%) and 292 (1.73%) participants developed adenoma and advanced adenoma, respectively. When age, sex, smoking, alcohol consumption, family history of colorectal cancer, and baseline adenoma risk were adjusted, the risk of adenoma recurrence was increased in metabolically healthy obese individuals (HR, 1.33; 95% confidence interval [CI], 1.12 to 1.57) and metabolically abnormal obese individuals (HR, 1.18; 95% CI, 1.08 to 1.30) but not in metabolically abnormal nonobese individuals (HR, 1.03; 95% CI, 0.94 to 1.13). Conclusions: In this study, metabolically healthy obese individuals and metabolically abnormal obese individuals exhibited increased risks of occurrence of colorectal adenoma diagnosed by surveillance colonoscopy. This finding implies that obesity itself, even without metabolic abnormalities, is associated with an increased risk of adenoma recurrence.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1976-2283
Relation: http://gutnliver.org/journal/view.html?doi=10.5009/gnl20084; https://doaj.org/toc/1976-2283
DOI: 10.5009/gnl20084
Access URL: https://doaj.org/article/dcd08177179440e6ac2c9d38ab6f438c
Accession Number: edsdoj.08177179440e6ac2c9d38ab6f438c
Database: Directory of Open Access Journals
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edsdoj&genre=article&issn=19762283&ISBN=&volume=15&issue=3&date=20210501&spage=383&pages=383-390&title=Gut and Liver&atitle=Metabolically%20Healthy%20Obesity%20Is%20Associated%20with%20an%20Increased%20Risk%20of%20Colorectal%20Adenoma%20Occurrence%20Diagnosed%20by%20Surveillance%20Colonoscopy&aulast=Hyunbeom%20Chae&id=DOI:10.5009/gnl20084
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
  – Url: https://doaj.org/article/dcd08177179440e6ac2c9d38ab6f438c
    Name: EDS - DOAJ (s8985755)
    Category: fullText
    Text: View record from DOAJ
    MouseOverText: View record from DOAJ
Header DbId: edsdoj
DbLabel: Directory of Open Access Journals
An: edsdoj.08177179440e6ac2c9d38ab6f438c
RelevancyScore: 949
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 948.723937988281
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Metabolically Healthy Obesity Is Associated with an Increased Risk of Colorectal Adenoma Occurrence Diagnosed by Surveillance Colonoscopy
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Hyunbeom+Chae%22">Hyunbeom Chae</searchLink><br /><searchLink fieldCode="AR" term="%22Hyo-Joon+Yang%22">Hyo-Joon Yang</searchLink><br /><searchLink fieldCode="AR" term="%22Soo-Kyung+Park%22">Soo-Kyung Park</searchLink><br /><searchLink fieldCode="AR" term="%22Yoon+Suk+Jung%22">Yoon Suk Jung</searchLink><br /><searchLink fieldCode="AR" term="%22Jung+Ho+Park%22">Jung Ho Park</searchLink><br /><searchLink fieldCode="AR" term="%22Dong+Il+Park%22">Dong Il Park</searchLink><br /><searchLink fieldCode="AR" term="%22Chong+Il+Sohn%22">Chong Il Sohn</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: Gut and Liver, Vol 15, Iss 3, Pp 383-390 (2021)
– Name: Publisher
  Label: Publisher Information
  Group: PubInfo
  Data: Gastroenterology Council for Gut and Liver, 2021.
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2021
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: LCC:Diseases of the digestive system. Gastroenterology
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22colorectal+neoplasm%22">colorectal neoplasm</searchLink><br /><searchLink fieldCode="DE" term="%22recurrence%22">recurrence</searchLink><br /><searchLink fieldCode="DE" term="%22obesity%22">obesity</searchLink><br /><searchLink fieldCode="DE" term="%22metabolically+benign%22">metabolically benign</searchLink><br /><searchLink fieldCode="DE" term="%22cohort+studies%22">cohort studies</searchLink><br /><searchLink fieldCode="DE" term="%22colonoscopy%22">colonoscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Diseases+of+the+digestive+system%2E+Gastroenterology%22">Diseases of the digestive system. Gastroenterology</searchLink><br /><searchLink fieldCode="DE" term="%22RC799-869%22">RC799-869</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Background/Aims: The risk of recurrence of colorectal adenoma among obese individuals without metabolic abnormalities or in those with metabolically healthy obesity is largely unexplored. Therefore, we longitudinally investigated the risk of adenoma occurrence in individuals undergoing surveillance colonoscopy according to metabolic status and obesity. Methods: This retrospective cohort study included 16,872 Korean adults who underwent their first screening colonoscopy between 2003 and 2012 and who then underwent follow-up colonoscopy until 2017. Participants were categorized into a metabolically healthy nonobese group (reference group), a metabolically healthy obese group, a metabolically abnormal nonobese group, and a metabolically abnormal obese group. Hazard ratios (HRs) for adenoma recurrence compared to the reference group were calculated in each group. Results: During a median follow-up duration of 47.3 months (interquartile range, 35.6 to 58.9 months), 3,673 (21.8%) and 292 (1.73%) participants developed adenoma and advanced adenoma, respectively. When age, sex, smoking, alcohol consumption, family history of colorectal cancer, and baseline adenoma risk were adjusted, the risk of adenoma recurrence was increased in metabolically healthy obese individuals (HR, 1.33; 95% confidence interval [CI], 1.12 to 1.57) and metabolically abnormal obese individuals (HR, 1.18; 95% CI, 1.08 to 1.30) but not in metabolically abnormal nonobese individuals (HR, 1.03; 95% CI, 0.94 to 1.13). Conclusions: In this study, metabolically healthy obese individuals and metabolically abnormal obese individuals exhibited increased risks of occurrence of colorectal adenoma diagnosed by surveillance colonoscopy. This finding implies that obesity itself, even without metabolic abnormalities, is associated with an increased risk of adenoma recurrence.
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: article
– Name: Format
  Label: File Description
  Group: SrcInfo
  Data: electronic resource
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: ISSN
  Label: ISSN
  Group: ISSN
  Data: 1976-2283
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: http://gutnliver.org/journal/view.html?doi=10.5009/gnl20084; https://doaj.org/toc/1976-2283
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.5009/gnl20084
– Name: URL
  Label: Access URL
  Group: URL
  Data: <link linkTarget="URL" linkTerm="https://doaj.org/article/dcd08177179440e6ac2c9d38ab6f438c" linkWindow="_blank">https://doaj.org/article/dcd08177179440e6ac2c9d38ab6f438c</link>
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsdoj.08177179440e6ac2c9d38ab6f438c
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsdoj&AN=edsdoj.08177179440e6ac2c9d38ab6f438c
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.5009/gnl20084
    Languages:
      – Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 383
    Subjects:
      – SubjectFull: colorectal neoplasm
        Type: general
      – SubjectFull: recurrence
        Type: general
      – SubjectFull: obesity
        Type: general
      – SubjectFull: metabolically benign
        Type: general
      – SubjectFull: cohort studies
        Type: general
      – SubjectFull: colonoscopy
        Type: general
      – SubjectFull: Diseases of the digestive system. Gastroenterology
        Type: general
      – SubjectFull: RC799-869
        Type: general
    Titles:
      – TitleFull: Metabolically Healthy Obesity Is Associated with an Increased Risk of Colorectal Adenoma Occurrence Diagnosed by Surveillance Colonoscopy
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Hyunbeom Chae
      – PersonEntity:
          Name:
            NameFull: Hyo-Joon Yang
      – PersonEntity:
          Name:
            NameFull: Soo-Kyung Park
      – PersonEntity:
          Name:
            NameFull: Yoon Suk Jung
      – PersonEntity:
          Name:
            NameFull: Jung Ho Park
      – PersonEntity:
          Name:
            NameFull: Dong Il Park
      – PersonEntity:
          Name:
            NameFull: Chong Il Sohn
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Type: published
              Y: 2021
          Identifiers:
            – Type: issn-print
              Value: 19762283
          Numbering:
            – Type: volume
              Value: 15
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: Gut and Liver
              Type: main
ResultId 1