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Bioactive polyketides and meroterpenoids from the mangrove-derived fungus Talaromyces flavus TGGP35

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Title: Bioactive polyketides and meroterpenoids from the mangrove-derived fungus Talaromyces flavus TGGP35
Authors: Jin Cai, Xueming Zhou, Bin Wang, Xuelong Zhang, Mengyao Luo, Longtao Huang, Ruoxi Wang, Yonghao Chen, Xiaoyang Li, Youping Luo, Guangying Chen, Fei Cao, Guolei Huang, Caijuan Zheng
Source: Frontiers in Microbiology, Vol 15 (2024)
Publisher Information: Frontiers Media S.A., 2024.
Publication Year: 2024
Collection: LCC:Microbiology
Subject Terms: Talaromyces flavus, polyketide, lactones, meroterpenoid, bioactivities, Microbiology, QR1-502
More Details: Six new polyketides, which includes three new lactones (talarotones A–C) (1–3), one new polyketide (talarotide A) (4), two new polyenes (talaroyenes A, B) (5, 6), together with one new meroterpenoid (talaropenoid A) (7) and 13 known compounds (8–20) were isolated from the mangrove-derived fungus Talaromyces flavus TGGP35. The structure and configuration of the compounds 1–7 were elucidated from the data obtained from HR-ESI-MS, IR, 1D/2D NMR spectroscopy, Mo2 (OAc)4-induced electronic circular dichroism (ECD), CD spectroscopy, and modified Mosher's method. Compounds 5 and 20 displayed antioxidant activity with IC50 values of 0.40 and 1.36 mM, respectively. Compounds 3, 6, 11, 16, and 17 displayed cytotoxic activity against human cancer cells Hela, A549, and had IC50 values ranging from 28.89 to 62.23 μM. Compounds 7, 10–12, and 14–18 exhibited moderate or potent anti-insect activity against newly hatched larvae of Helicoverpa armigera Hubner, with IC50 values in the range 50–200 μg/mL. Compound 18 showed antibacterial activity against Ralstonia solanacearum with the MIC value of 50 μg/mL.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1664-302X
Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2024.1342843/full; https://doaj.org/toc/1664-302X
DOI: 10.3389/fmicb.2024.1342843
Access URL: https://doaj.org/article/0474afbbc648482bbbf630f0378a84d3
Accession Number: edsdoj.0474afbbc648482bbbf630f0378a84d3
Database: Directory of Open Access Journals
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  Data: Bioactive polyketides and meroterpenoids from the mangrove-derived fungus Talaromyces flavus TGGP35
– Name: Author
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  Data: <searchLink fieldCode="AR" term="%22Jin+Cai%22">Jin Cai</searchLink><br /><searchLink fieldCode="AR" term="%22Xueming+Zhou%22">Xueming Zhou</searchLink><br /><searchLink fieldCode="AR" term="%22Bin+Wang%22">Bin Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Xuelong+Zhang%22">Xuelong Zhang</searchLink><br /><searchLink fieldCode="AR" term="%22Mengyao+Luo%22">Mengyao Luo</searchLink><br /><searchLink fieldCode="AR" term="%22Longtao+Huang%22">Longtao Huang</searchLink><br /><searchLink fieldCode="AR" term="%22Ruoxi+Wang%22">Ruoxi Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Yonghao+Chen%22">Yonghao Chen</searchLink><br /><searchLink fieldCode="AR" term="%22Xiaoyang+Li%22">Xiaoyang Li</searchLink><br /><searchLink fieldCode="AR" term="%22Youping+Luo%22">Youping Luo</searchLink><br /><searchLink fieldCode="AR" term="%22Guangying+Chen%22">Guangying Chen</searchLink><br /><searchLink fieldCode="AR" term="%22Fei+Cao%22">Fei Cao</searchLink><br /><searchLink fieldCode="AR" term="%22Guolei+Huang%22">Guolei Huang</searchLink><br /><searchLink fieldCode="AR" term="%22Caijuan+Zheng%22">Caijuan Zheng</searchLink>
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  Data: Frontiers in Microbiology, Vol 15 (2024)
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  Data: Frontiers Media S.A., 2024.
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  Data: 2024
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  Data: LCC:Microbiology
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  Data: <searchLink fieldCode="DE" term="%22Talaromyces+flavus%22">Talaromyces flavus</searchLink><br /><searchLink fieldCode="DE" term="%22polyketide%22">polyketide</searchLink><br /><searchLink fieldCode="DE" term="%22lactones%22">lactones</searchLink><br /><searchLink fieldCode="DE" term="%22meroterpenoid%22">meroterpenoid</searchLink><br /><searchLink fieldCode="DE" term="%22bioactivities%22">bioactivities</searchLink><br /><searchLink fieldCode="DE" term="%22Microbiology%22">Microbiology</searchLink><br /><searchLink fieldCode="DE" term="%22QR1-502%22">QR1-502</searchLink>
– Name: Abstract
  Label: Description
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  Data: Six new polyketides, which includes three new lactones (talarotones A–C) (1–3), one new polyketide (talarotide A) (4), two new polyenes (talaroyenes A, B) (5, 6), together with one new meroterpenoid (talaropenoid A) (7) and 13 known compounds (8–20) were isolated from the mangrove-derived fungus Talaromyces flavus TGGP35. The structure and configuration of the compounds 1–7 were elucidated from the data obtained from HR-ESI-MS, IR, 1D/2D NMR spectroscopy, Mo2 (OAc)4-induced electronic circular dichroism (ECD), CD spectroscopy, and modified Mosher's method. Compounds 5 and 20 displayed antioxidant activity with IC50 values of 0.40 and 1.36 mM, respectively. Compounds 3, 6, 11, 16, and 17 displayed cytotoxic activity against human cancer cells Hela, A549, and had IC50 values ranging from 28.89 to 62.23 μM. Compounds 7, 10–12, and 14–18 exhibited moderate or potent anti-insect activity against newly hatched larvae of Helicoverpa armigera Hubner, with IC50 values in the range 50–200 μg/mL. Compound 18 showed antibacterial activity against Ralstonia solanacearum with the MIC value of 50 μg/mL.
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  Data: https://www.frontiersin.org/articles/10.3389/fmicb.2024.1342843/full; https://doaj.org/toc/1664-302X
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        Value: 10.3389/fmicb.2024.1342843
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      – Text: English
    Subjects:
      – SubjectFull: Talaromyces flavus
        Type: general
      – SubjectFull: polyketide
        Type: general
      – SubjectFull: lactones
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      – SubjectFull: meroterpenoid
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