New living evidence resource of human and non-human studies for early intervention and research prioritisation in anxiety, depression and psychosis

Bibliographic Details
Title: New living evidence resource of human and non-human studies for early intervention and research prioritisation in anxiety, depression and psychosis
Authors: Toshi A Furukawa, Andrea Cipriani, Edoardo Giuseppe Ostinelli, Georgia Salanti, Malcolm Macleod, Emily Sena, James Thomas, Miranda Wolpert, Susan Michie, Jennifer Potts, Matthias Egger, Soraya Seedat, Stefan Leucht, Virginia Chiocchia, Karla Soares-Weiser, Robert McCutcheon, Ayse Kurtulmus, David Gilbert, Sophie Chung, Spyridon Siafis, Carmen Moreno, Lea Milligan, Janna Hastings, Parisa Mansoori, James M Barker, Simonne Wright, Matilda Simpson, Olufisayo Elugbadebo, Thomy Tonia, Rania Elgarf, Ouma Simple, Niall Boyce, Anjuli Sharma, Julian H Elliott
Source: BMJ Mental Health, Vol 26, Iss 1 (2023)
Publisher Information: BMJ Publishing Group, 2023.
Publication Year: 2023
Collection: LCC:Psychiatry
Subject Terms: Psychiatry, RC435-571
More Details: In anxiety, depression and psychosis, there has been frustratingly slow progress in developing novel therapies that make a substantial difference in practice, as well as in predicting which treatments will work for whom and in what contexts. To intervene early in the process and deliver optimal care to patients, we need to understand the underlying mechanisms of mental health conditions, develop safe and effective interventions that target these mechanisms, and improve our capabilities in timely diagnosis and reliable prediction of symptom trajectories. Better synthesis of existing evidence is one way to reduce waste and improve efficiency in research towards these ends. Living systematic reviews produce rigorous, up-to-date and informative evidence summaries that are particularly important where research is emerging rapidly, current evidence is uncertain and new findings might change policy or practice. Global Alliance for Living Evidence on aNxiety, depressiOn and pSychosis (GALENOS) aims to tackle the challenges of mental health science research by cataloguing and evaluating the full spectrum of relevant scientific research including both human and preclinical studies. GALENOS will also allow the mental health community—including patients, carers, clinicians, researchers and funders—to better identify the research questions that most urgently need to be answered. By creating open-access datasets and outputs in a state-of-the-art online resource, GALENOS will help identify promising signals early in the research process. This will accelerate translation from discovery science into effective new interventions for anxiety, depression and psychosis, ready to be translated in clinical practice across the world.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2755-9734
Relation: https://ebmh.bmj.com/content/26/1/e300759.full; https://doaj.org/toc/2755-9734
DOI: 10.1136/bmjment-2023-300759
Access URL: https://doaj.org/article/044de1dd54964197a4947ffbff17d6d6
Accession Number: edsdoj.044de1dd54964197a4947ffbff17d6d6
Database: Directory of Open Access Journals
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  Data: In anxiety, depression and psychosis, there has been frustratingly slow progress in developing novel therapies that make a substantial difference in practice, as well as in predicting which treatments will work for whom and in what contexts. To intervene early in the process and deliver optimal care to patients, we need to understand the underlying mechanisms of mental health conditions, develop safe and effective interventions that target these mechanisms, and improve our capabilities in timely diagnosis and reliable prediction of symptom trajectories. Better synthesis of existing evidence is one way to reduce waste and improve efficiency in research towards these ends. Living systematic reviews produce rigorous, up-to-date and informative evidence summaries that are particularly important where research is emerging rapidly, current evidence is uncertain and new findings might change policy or practice. Global Alliance for Living Evidence on aNxiety, depressiOn and pSychosis (GALENOS) aims to tackle the challenges of mental health science research by cataloguing and evaluating the full spectrum of relevant scientific research including both human and preclinical studies. GALENOS will also allow the mental health community—including patients, carers, clinicians, researchers and funders—to better identify the research questions that most urgently need to be answered. By creating open-access datasets and outputs in a state-of-the-art online resource, GALENOS will help identify promising signals early in the research process. This will accelerate translation from discovery science into effective new interventions for anxiety, depression and psychosis, ready to be translated in clinical practice across the world.
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