Study of intracellular signaling pathways in Chronic Myeloproliferative Neoplasms
| Title: | Study of intracellular signaling pathways in Chronic Myeloproliferative Neoplasms |
|---|---|
| Authors: | Martinelli, Serena |
| Publisher Information: | Florence: Firenze University Press, 2017. |
| Publication Year: | 2017 |
| More Details: | A gain-of-function mutation in Janus kinase 2 (JAK2V617F) is at the basis of the majority of chronic myeloproliferative neoplasms (MPN). Enhanced activation of other downstream pathways including the PI3K/mTOR pathway has been documented as well. In this study we evaluated the effects of JAK1/2 inhibitors, alone and in combination with mTOR, with a dual mTOR/PI3K inhibitor and with a pan PI3K inhibitor in in-vitro and in-vivo MPN models. Our findings of strong synergy between the JAK2 inhibitors and mTOR/PI3K inhibitor suggested that we might be able to administer these drugs at lower concentrations than when the drugs are used individually. This provides a framework for combination trials using compounds in patients with myeloproliferative neoplasms |
| Document Type: | eBook |
| File Description: | image/jpeg |
| Language: | English |
| ISBN: | 978-88-6453-565-4 978-88-6453-564-7 978-88-927-3168-4 |
| ISSN: | 2612-8020 |
| Relation: | Premio Tesi di Dottorato |
| DOI: | 10.36253/978-88-6453-565-4 |
| Access URL: | https://directory.doabooks.org/handle/20.500.12854/83462 https://library.oapen.org/handle/20.500.12657/55390 https://library.oapen.org/bitstream/20.500.12657/55390/1/9788864535654.pdf |
| Rights: | open access Attribution 4.0 International URL: http://purl.org/coar/access_right/c_abf2 URL: https://creativecommons.org/licenses/by/4.0/ |
| Notes: | ONIX_20220531_9788864535654_674 OCN: 1229607373 |
| Accession Number: | edsdob.20.500.12854.83462 |
| Database: | Directory of Open Access Books |
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