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New Diagnostic and Therapeutic Aspects of Thrombotic Thrombocytopenic Purpura

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Title: New Diagnostic and Therapeutic Aspects of Thrombotic Thrombocytopenic Purpura
Contributors: Mancini, Ilaria, Artoni, Andrea
Publisher Information: Basel: MDPI - Multidisciplinary Digital Publishing Institute, 2025.
Publication Year: 2025
Subject Terms: thrombotic thrombocytopenic purpura (TTP), ADAMTS13, ADAMTS13 testing, differential diagnosis of thrombotic microangiopathy disease awareness, TTP therapy, refractoriness, exacerbation, thromboembolic complications, new therapeutic approaches, long-term outcomes, TTP relapse prevention, pregnancy management, management of predisposing conditions/precipitating factors, hospital resources, Medicine and Nursing, Mental health services
More Details: Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening thrombotic microangiopathy caused by congenital or acquired severe deficiency of the von Willebrand factor cleaving protease, ADAMTS13. Acute TTP is a medical emergency requiring a rapid differential diagnosis and immediate treatment, which is often challenging due to the overlap between clinical and laboratory features and other thrombotic microangiopathies. Diagnostic and therapeutic advancements over the past decade, including the increased availability of ADAMTS13 testing and the development of caplacizumab, the first targeted therapy for acquired TTP, have significantly improved the management of acute TTP and reduced the burden of short-term outcomes such as mortality and exacerbation of acute disease. Concurrently, new clinical challenges have emerged, to mention but one, addressing the burden of long-term complications of TTP and cardiovascular comorbidities in TTP patients in remission. This Special Issue will cover new diagnostic and therapeutic aspects of TTP care, with the scope of advancing our knowledge and clinical intervention to address the current challenges of TTP management. Original, review, and guidance/guideline papers are welcome.
Document Type: eBook
File Description: application/octet-stream
Language: English
ISBN: 978-3-7258-2859-3
978-3-7258-2860-9
DOI: 10.3390/books978-3-7258-2860-9
Access URL: https://directory.doabooks.org/handle/20.500.12854/153103
https://mdpi.com/books/pdfview/book/10399
Rights: Attribution 4.0 International
open access
URL: http://purl.org/coar/access_right/c_abf2
URL: https://creativecommons.org/licenses/by/4.0/
Notes: ONIX_20250220_9783725828593_467
Accession Number: edsdob.20.500.12854.153103
Database: Directory of Open Access Books
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  Data: New Diagnostic and Therapeutic Aspects of Thrombotic Thrombocytopenic Purpura
– Name: Author
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  Group: Au
  Data: Mancini, Ilaria<br />Artoni, Andrea
– Name: Publisher
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  Data: Basel: MDPI - Multidisciplinary Digital Publishing Institute, 2025.
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  Data: 2025
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  Data: <searchLink fieldCode="DE" term="%22thrombotic+thrombocytopenic+purpura+%28TTP%29%22">thrombotic thrombocytopenic purpura (TTP)</searchLink><br /><searchLink fieldCode="DE" term="%22ADAMTS13%22">ADAMTS13</searchLink><br /><searchLink fieldCode="DE" term="%22ADAMTS13+testing%22">ADAMTS13 testing</searchLink><br /><searchLink fieldCode="DE" term="%22differential+diagnosis+of+thrombotic+microangiopathy+disease+awareness%22">differential diagnosis of thrombotic microangiopathy disease awareness</searchLink><br /><searchLink fieldCode="DE" term="%22TTP+therapy%22">TTP therapy</searchLink><br /><searchLink fieldCode="DE" term="%22refractoriness%22">refractoriness</searchLink><br /><searchLink fieldCode="DE" term="%22exacerbation%22">exacerbation</searchLink><br /><searchLink fieldCode="DE" term="%22thromboembolic+complications%22">thromboembolic complications</searchLink><br /><searchLink fieldCode="DE" term="%22new+therapeutic+approaches%22">new therapeutic approaches</searchLink><br /><searchLink fieldCode="DE" term="%22long-term+outcomes%22">long-term outcomes</searchLink><br /><searchLink fieldCode="DE" term="%22TTP+relapse+prevention%22">TTP relapse prevention</searchLink><br /><searchLink fieldCode="DE" term="%22pregnancy+management%22">pregnancy management</searchLink><br /><searchLink fieldCode="DE" term="%22management+of+predisposing+conditions%2Fprecipitating+factors%22">management of predisposing conditions/precipitating factors</searchLink><br /><searchLink fieldCode="DE" term="%22hospital+resources%22">hospital resources</searchLink><br /><searchLink fieldCode="DE" term="%22Medicine+and+Nursing%22">Medicine and Nursing</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+health+services%22">Mental health services</searchLink>
– Name: Abstract
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  Group: Ab
  Data: Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening thrombotic microangiopathy caused by congenital or acquired severe deficiency of the von Willebrand factor cleaving protease, ADAMTS13. Acute TTP is a medical emergency requiring a rapid differential diagnosis and immediate treatment, which is often challenging due to the overlap between clinical and laboratory features and other thrombotic microangiopathies. Diagnostic and therapeutic advancements over the past decade, including the increased availability of ADAMTS13 testing and the development of caplacizumab, the first targeted therapy for acquired TTP, have significantly improved the management of acute TTP and reduced the burden of short-term outcomes such as mortality and exacerbation of acute disease. Concurrently, new clinical challenges have emerged, to mention but one, addressing the burden of long-term complications of TTP and cardiovascular comorbidities in TTP patients in remission. This Special Issue will cover new diagnostic and therapeutic aspects of TTP care, with the scope of advancing our knowledge and clinical intervention to address the current challenges of TTP management. Original, review, and guidance/guideline papers are welcome.
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  Data: 978-3-7258-2859-3<br />978-3-7258-2860-9
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  Data: 10.3390/books978-3-7258-2860-9
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  Data: <link linkTarget="URL" linkTerm="https://directory.doabooks.org/handle/20.500.12854/153103" linkWindow="_blank">https://directory.doabooks.org/handle/20.500.12854/153103</link><br /><link linkTarget="URL" linkTerm="https://mdpi.com/books/pdfview/book/10399" linkWindow="_blank">https://mdpi.com/books/pdfview/book/10399</link>
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  Data: Attribution 4.0 International<br />open access<br />URL: http://purl.org/coar/access_right/c_abf2<br />URL: https://creativecommons.org/licenses/by/4.0/
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  Data: edsdob.20.500.12854.153103
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RecordInfo BibRecord:
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        Value: 10.3390/books978-3-7258-2860-9
    Languages:
      – Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 142
    Subjects:
      – SubjectFull: thrombotic thrombocytopenic purpura (TTP)
        Type: general
      – SubjectFull: ADAMTS13
        Type: general
      – SubjectFull: ADAMTS13 testing
        Type: general
      – SubjectFull: differential diagnosis of thrombotic microangiopathy disease awareness
        Type: general
      – SubjectFull: TTP therapy
        Type: general
      – SubjectFull: refractoriness
        Type: general
      – SubjectFull: exacerbation
        Type: general
      – SubjectFull: thromboembolic complications
        Type: general
      – SubjectFull: new therapeutic approaches
        Type: general
      – SubjectFull: long-term outcomes
        Type: general
      – SubjectFull: TTP relapse prevention
        Type: general
      – SubjectFull: pregnancy management
        Type: general
      – SubjectFull: management of predisposing conditions/precipitating factors
        Type: general
      – SubjectFull: hospital resources
        Type: general
      – SubjectFull: Medicine and Nursing
        Type: general
      – SubjectFull: Mental health services
        Type: general
    Titles:
      – TitleFull: New Diagnostic and Therapeutic Aspects of Thrombotic Thrombocytopenic Purpura
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          Name:
            NameFull: Mancini, Ilaria
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            NameFull: Artoni, Andrea
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            – D: 01
              M: 01
              Type: published
              Y: 2025
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              Value: 9783725828593
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              Value: 9783725828609
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