Restricted mean survival time estimate using covariate adjusted pseudovalue regression to improve precision
| Title: | Restricted mean survival time estimate using covariate adjusted pseudovalue regression to improve precision |
|---|---|
| Authors: | Li, Yunfan, Ross, Jessica L., Smith, Aaron M., Miller, David P. |
| Publication Year: | 2022 |
| Collection: | Statistics |
| Subject Terms: | Statistics - Methodology, Statistics - Applications |
| More Details: | Covariate adjustment is desired by both practitioners and regulators of randomized clinical trials because it improves precision for estimating treatment effects. However, covariate adjustment presents a particular challenge in time-to-event analysis. We propose to apply covariate adjusted pseudovalue regression to estimate between-treatment difference in restricted mean survival times (RMST). Our proposed method incorporates a prognostic covariate to increase precision of treatment effect estimate, maintaining strict type I error control without introducing bias. In addition, the amount of increase in precision can be quantified and taken into account in sample size calculation at the study design stage. Consequently, our proposed method provides the ability to design smaller randomized studies at no expense to statistical power. |
| Document Type: | Working Paper |
| Access URL: | http://arxiv.org/abs/2208.04495 |
| Accession Number: | edsarx.2208.04495 |
| Database: | arXiv |
| FullText | Text: Availability: 0 CustomLinks: – Url: http://arxiv.org/abs/2208.04495 Name: EDS - Arxiv Category: fullText Text: View this record from Arxiv MouseOverText: View this record from Arxiv – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edsarx&genre=article&issn=&ISBN=&volume=&issue=&date=20220808&spage=&pages=&title=Restricted mean survival time estimate using covariate adjusted pseudovalue regression to improve precision&atitle=Restricted%20mean%20survival%20time%20estimate%20using%20covariate%20adjusted%20pseudovalue%20regression%20to%20improve%20precision&aulast=Li%2C%20Yunfan&id=DOI: Name: Full Text Finder (for New FTF UI) (s8985755) Category: fullText Text: Find It @ SCU Libraries MouseOverText: Find It @ SCU Libraries |
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| RecordInfo | BibRecord: BibEntity: Subjects: – SubjectFull: Statistics - Methodology Type: general – SubjectFull: Statistics - Applications Type: general Titles: – TitleFull: Restricted mean survival time estimate using covariate adjusted pseudovalue regression to improve precision Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Li, Yunfan – PersonEntity: Name: NameFull: Ross, Jessica L. – PersonEntity: Name: NameFull: Smith, Aaron M. – PersonEntity: Name: NameFull: Miller, David P. IsPartOfRelationships: – BibEntity: Dates: – D: 08 M: 08 Type: published Y: 2022 |
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