Protein Regge Trajectories, Phase Coexistence and Physics of Alzheimer's Disease
| Title: | Protein Regge Trajectories, Phase Coexistence and Physics of Alzheimer's Disease |
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| Authors: | Krokhotin, Andrei, Niemi, Antti J. |
| Publication Year: | 2011 |
| Collection: | Condensed Matter Physics (Other) Quantitative Biology |
| Subject Terms: | Quantitative Biology - Biomolecules, Condensed Matter - Soft Condensed Matter, Physics - Biological Physics |
| More Details: | Alzheimer's disease causes severe neurodegeneration in the brain that leads to a certain death. The defining factor is the formation of extracellular senile amyloid plaques in the brain. However, therapeutic approaches to remove them have not been effective in humans, and so our understanding of the cause of Alzheimer's disease remains incomplete. Here we investigate physical processes that might relate to its onset. Instead of the extracellular amyloid, we scrutinize the intracellular domain of its precursor protein. We argue for a phenomenon that has never before been discussed in the context of polymer physics: Like ice and water together, the intracellular domain of the amyloid precursor protein forms a state of phase coexistence with another protein. This leads to an inherent instability that could well be among the missing pieces in the puzzle of Alzheimer's disease. Comment: 4 figures |
| Document Type: | Working Paper |
| Access URL: | http://arxiv.org/abs/1109.1221 |
| Accession Number: | edsarx.1109.1221 |
| Database: | arXiv |
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| RecordInfo | BibRecord: BibEntity: Subjects: – SubjectFull: Quantitative Biology - Biomolecules Type: general – SubjectFull: Condensed Matter - Soft Condensed Matter Type: general – SubjectFull: Physics - Biological Physics Type: general Titles: – TitleFull: Protein Regge Trajectories, Phase Coexistence and Physics of Alzheimer's Disease Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Krokhotin, Andrei – PersonEntity: Name: NameFull: Niemi, Antti J. IsPartOfRelationships: – BibEntity: Dates: – D: 06 M: 09 Type: published Y: 2011 |
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