Bibliographic Details
| Title: |
Antifungal Susceptibility Profiles and Drug Resistance Mechanisms of Clinical Lomentospora prolificansIsolates |
| Authors: |
Wu, Yongqin, Grossman, Nina, Totten, Marissa, Memon, Warda, Fitzgerald, Anna, Ying, Chunmei, Zhang, Sean X. |
| Source: |
Antimicrobial Agents and Chemotherapy; August 2020, Vol. 64 Issue: 11 |
| Abstract: |
Lomentospora prolificansis an opportunistic fungal pathogen with low susceptibility to current antifungal drugs. Here, we tested the in vitrosusceptibility of 8 drugs against 42 clinical L. prolificansisolates. All isolates showed high MICs to voriconazole (MIC90>16 μg/ml), itraconazole (MIC90>16 μg/ml), posaconazole (MIC90>16 μg/ml), isavuconazole (MIC90>16 μg/ml), amphotericin B (MIC90>16 μg/ml), and terbinafine (MIC90>64 μg/ml) and high minimum effective concentrations (MECs) to micafungin (MEC90>8 μg/ml), with the exception of miltefosine showing an MIC90value of 4 μg/ml. |
| Database: |
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