Effects of a Leukotriene Antagonist on the Early Hemodynamic Manifestations of Group B Streptococcal Sepsis in Piglets
| Title: | Effects of a Leukotriene Antagonist on the Early Hemodynamic Manifestations of Group B Streptococcal Sepsis in Piglets |
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| Authors: | GOLDBERG, RONALD N., SUGUIHARA, CLEIDE, STREITFELD, MURRAY M., BANCALARI, ALDO, CLARK, MARTIN R., BANCALARI, EDUARDO |
| Source: | Pediatric Research (Ovid); October 1986, Vol. 20 Issue: 10 p1004-1008, 5p |
| Abstract: | In order to evaluate the influence of leukotrienes on group B streptococcal (GBS) sepsis we studied the effect of a leukotriene antagonist, FPL 57231, on the early hemodynamic changes occurring secondary to an infusion of live GBS. Paralyzed, mechanically ventilated piglets received a continuous intravenous infusion of bacteria (5 × 108org/kg/min) while systemic arterial pressure and pulmonary artery pressure were measured continuously. Cardiac output was measured by thermodilution; and plasma samples for determination of thromboxane B2and 6-keto-PGF1αwere taken at preset intervals. In addition to GBS, treatment animals received a continuous infusion of FPL 57231 starting 15 min after the bacterial infusion was begun. Study animals as a whole responded to bacteria within 15 min with a marked elevation in pulmonary artery pressure from 13.6 ± 4 to 44.6 ± 6 mm Hg (p< 0.001), and a decline in PaO2(79 ± 9 to 44 ± 5 mm Hg) (p< 0.001) and a cardiac output (0.27 ± 0.07 to 0.15 ± 0.06 liter/min/kg) (p< 0.0001). In animals treated with FPL 57231 these changes were reversed or significantly attenuated by 60 min. In the control group pH deteriorated significantly to 7.17 ± 0.1 compared to baseline values (p< 0.01) by 60 min, while treatment group animals maintained a pH of 7.3 ± 0.23. Thromboxane B2and 6-keto PGF1αwere similar in both groups and did not change during the study period. In addition, survival was significantly longer in treatment (191 ± 44 min) compared to control animals (100 ± 32 min) (p< 0.01). These data suggest that FPL 57231 may attenuate the early cardiovascular changes accompanying GBS infection and positively influence survival without modifying thromboxane or 6-keto PGF1αlevels. These results imply that leukotrienes influence the early hemodynamic manifestations of GBS sepsis. |
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| Header | DbId: edo DbLabel: Supplemental Index An: ejs49467527 RelevancyScore: 804 AccessLevel: 6 PubType: Periodical PubTypeId: serialPeriodical PreciseRelevancyScore: 803.93701171875 |
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| Items | – Name: Title Label: Title Group: Ti Data: Effects of a Leukotriene Antagonist on the Early Hemodynamic Manifestations of Group B Streptococcal Sepsis in Piglets – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22GOLDBERG%2C+RONALD+N%2E%22">GOLDBERG, RONALD N.</searchLink><br /><searchLink fieldCode="AR" term="%22SUGUIHARA%2C+CLEIDE%22">SUGUIHARA, CLEIDE</searchLink><br /><searchLink fieldCode="AR" term="%22STREITFELD%2C+MURRAY+M%2E%22">STREITFELD, MURRAY M.</searchLink><br /><searchLink fieldCode="AR" term="%22BANCALARI%2C+ALDO%22">BANCALARI, ALDO</searchLink><br /><searchLink fieldCode="AR" term="%22CLARK%2C+MARTIN+R%2E%22">CLARK, MARTIN R.</searchLink><br /><searchLink fieldCode="AR" term="%22BANCALARI%2C+EDUARDO%22">BANCALARI, EDUARDO</searchLink> – Name: TitleSource Label: Source Group: Src Data: Pediatric Research (Ovid); October 1986, Vol. 20 Issue: 10 p1004-1008, 5p – Name: Abstract Label: Abstract Group: Ab Data: In order to evaluate the influence of leukotrienes on group B streptococcal (GBS) sepsis we studied the effect of a leukotriene antagonist, FPL 57231, on the early hemodynamic changes occurring secondary to an infusion of live GBS. Paralyzed, mechanically ventilated piglets received a continuous intravenous infusion of bacteria (5 × 108org/kg/min) while systemic arterial pressure and pulmonary artery pressure were measured continuously. Cardiac output was measured by thermodilution; and plasma samples for determination of thromboxane B2and 6-keto-PGF1αwere taken at preset intervals. In addition to GBS, treatment animals received a continuous infusion of FPL 57231 starting 15 min after the bacterial infusion was begun. Study animals as a whole responded to bacteria within 15 min with a marked elevation in pulmonary artery pressure from 13.6 ± 4 to 44.6 ± 6 mm Hg (p< 0.001), and a decline in PaO2(79 ± 9 to 44 ± 5 mm Hg) (p< 0.001) and a cardiac output (0.27 ± 0.07 to 0.15 ± 0.06 liter/min/kg) (p< 0.0001). In animals treated with FPL 57231 these changes were reversed or significantly attenuated by 60 min. In the control group pH deteriorated significantly to 7.17 ± 0.1 compared to baseline values (p< 0.01) by 60 min, while treatment group animals maintained a pH of 7.3 ± 0.23. Thromboxane B2and 6-keto PGF1αwere similar in both groups and did not change during the study period. In addition, survival was significantly longer in treatment (191 ± 44 min) compared to control animals (100 ± 32 min) (p< 0.01). These data suggest that FPL 57231 may attenuate the early cardiovascular changes accompanying GBS infection and positively influence survival without modifying thromboxane or 6-keto PGF1αlevels. These results imply that leukotrienes influence the early hemodynamic manifestations of GBS sepsis. |
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| RecordInfo | BibRecord: BibEntity: Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 1004 Titles: – TitleFull: Effects of a Leukotriene Antagonist on the Early Hemodynamic Manifestations of Group B Streptococcal Sepsis in Piglets Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: GOLDBERG, RONALD N. – PersonEntity: Name: NameFull: SUGUIHARA, CLEIDE – PersonEntity: Name: NameFull: STREITFELD, MURRAY M. – PersonEntity: Name: NameFull: BANCALARI, ALDO – PersonEntity: Name: NameFull: CLARK, MARTIN R. – PersonEntity: Name: NameFull: BANCALARI, EDUARDO IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: October 1986 Type: published Y: 1986 Identifiers: – Type: issn-print Value: 00313998 – Type: issn-print Value: 15300447 Numbering: – Type: volume Value: 20 – Type: issue Value: 10 Titles: – TitleFull: Pediatric Research (Ovid) Type: main |
| ResultId | 1 |