Adenosine modulates methylmercuric chloride (MeHgCl)-inducedd-aspartate release from neonatal rat primary astrocyte cultures
| Title: | Adenosine modulates methylmercuric chloride (MeHgCl)-inducedd-aspartate release from neonatal rat primary astrocyte cultures |
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| Authors: | Aschner, M., Mullaney, K.J., Wagoner, D.E., Lash, L.H., Kimelberg, H.K. |
| Source: | Brain Research; August 1995, Vol. 689 Issue: 1 p1-8, 8p |
| Abstract: | The effects of adenosine, and selective adenosine receptor agonists and antagonists on methylmercury (MeHg)-induced aspartate release were studied in neonatal rat primary astrocyte cultures. Whereas basal levels ofd-[3H]aspartate release were unchanged upon treatment with adenosine or selective A1 receptor agonists, N6-cyclopentyladenosine (CPA), cyclohexyladenosine (CHA), and R-phenylisopropyladenosine (R-PIA), all partially reversed the MeHg-induced release ofd-aspartate. Treatment of astrocytes with the xanthine derivative, theophylline, an adenosine antagonist, reversed the inhibitory effect of adenosine on MeHg-inducedd-[3H]aspartate release. Since the effect of MeHg ond-[3H]aspartate release is known to be associated with sulfhydryl (-SH) groups which are controlled by intracellular glutathione concentrations [GSH]i, we also evaluated the effects of adenosine, the A1 agonists CPA and CHP, and the adenosine antagonist, theophylline, on astrocytic [GSH]i. Attenuation of the stimulatory effect of MeHg ond-[3H]aspartate release by adenosine and its agonists occurred in the presence of reduced astrocytic [GSH]i, suggesting that other mechanisms must be invoked for this protective effect. Whilst the mechanism of MeHg-inducedd-[3H]aspartate release is not known, the data suggest a role for adenosine in its regulation. |
| Database: | Supplemental Index |
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| Items | – Name: Title Label: Title Group: Ti Data: Adenosine modulates methylmercuric chloride (MeHgCl)-inducedd-aspartate release from neonatal rat primary astrocyte cultures – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Aschner%2C+M%2E%22">Aschner, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Mullaney%2C+K%2EJ%2E%22">Mullaney, K.J.</searchLink><br /><searchLink fieldCode="AR" term="%22Wagoner%2C+D%2EE%2E%22">Wagoner, D.E.</searchLink><br /><searchLink fieldCode="AR" term="%22Lash%2C+L%2EH%2E%22">Lash, L.H.</searchLink><br /><searchLink fieldCode="AR" term="%22Kimelberg%2C+H%2EK%2E%22">Kimelberg, H.K.</searchLink> – Name: TitleSource Label: Source Group: Src Data: Brain Research; August 1995, Vol. 689 Issue: 1 p1-8, 8p – Name: Abstract Label: Abstract Group: Ab Data: The effects of adenosine, and selective adenosine receptor agonists and antagonists on methylmercury (MeHg)-induced aspartate release were studied in neonatal rat primary astrocyte cultures. Whereas basal levels ofd-[3H]aspartate release were unchanged upon treatment with adenosine or selective A1 receptor agonists, N6-cyclopentyladenosine (CPA), cyclohexyladenosine (CHA), and R-phenylisopropyladenosine (R-PIA), all partially reversed the MeHg-induced release ofd-aspartate. Treatment of astrocytes with the xanthine derivative, theophylline, an adenosine antagonist, reversed the inhibitory effect of adenosine on MeHg-inducedd-[3H]aspartate release. Since the effect of MeHg ond-[3H]aspartate release is known to be associated with sulfhydryl (-SH) groups which are controlled by intracellular glutathione concentrations [GSH]i, we also evaluated the effects of adenosine, the A1 agonists CPA and CHP, and the adenosine antagonist, theophylline, on astrocytic [GSH]i. Attenuation of the stimulatory effect of MeHg ond-[3H]aspartate release by adenosine and its agonists occurred in the presence of reduced astrocytic [GSH]i, suggesting that other mechanisms must be invoked for this protective effect. Whilst the mechanism of MeHg-inducedd-[3H]aspartate release is not known, the data suggest a role for adenosine in its regulation. |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/0006-8993(95)00496-D Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 1 Titles: – TitleFull: Adenosine modulates methylmercuric chloride (MeHgCl)-inducedd-aspartate release from neonatal rat primary astrocyte cultures Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Aschner, M. – PersonEntity: Name: NameFull: Mullaney, K.J. – PersonEntity: Name: NameFull: Wagoner, D.E. – PersonEntity: Name: NameFull: Lash, L.H. – PersonEntity: Name: NameFull: Kimelberg, H.K. IsPartOfRelationships: – BibEntity: Dates: – D: 14 M: 08 Text: August 1995 Type: published Y: 1995 Identifiers: – Type: issn-print Value: 00068993 Numbering: – Type: volume Value: 689 – Type: issue Value: 1 Titles: – TitleFull: Brain Research Type: main |
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