The Impact of High Sensitivity C-Reactive Protein Level on Coronary Artery Spasm as Assessed by Intracoronary Acetylcholine Provocation Test.
| Title: | The Impact of High Sensitivity C-Reactive Protein Level on Coronary Artery Spasm as Assessed by Intracoronary Acetylcholine Provocation Test. |
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| Authors: | Ji Young Park, Seung-Woon Rha, Yong-Jian Li, Kang-Yin Chen, Byoung Geol Choi, Se Yeon Choi, Sung Kee Ryu, Jae Woong Choi, Tae Kyun Kim, Jeong Min Kim, Yoon Suk Bak, Jae Hoon Lee, Sung Il Im, Sun Won Kim, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Chang Gyu Park |
| Source: | Yonsei Medical Journal; Nov2013, Vol. 54 Issue 6, p1299-1304, 6p |
| Abstract: | Purpose: High sensitive C-reactive protein (hs CRP) is well known as a strong risk factor of cardiovascular disease (CVD). The aim of this study is to evaluate the impact of elevated hs CRP on coronary artery spasm (CAS) as assessed by in-tracoronary acetylcholine (ACh) provocation test. Materials and Methods: A total of 1729 consecutive patients without significant CVD who underwent coronary angiography and intracoronary ACh test between November 2004 and August 2010 were analyzed. The patients were divided into five groups according to quintiles of hs CRP levels. Results: At baseline, the prevalence of elderly, hypertension, diabetes mellitus, current smoking, and lipid levels were higher in patients with higher hs CRP. During ACh test, the incidences of significant CAS, ischemic elec-trocardiography (EKG) change, multivessel, and diffuse CAS were higher in patients with higher hs CRP. Multivariate analysis showed that the old age (OR=1.01, CI; 1.0-1.02,p=0.0226), myocardial bridge (OR=3.34, CI; 2.16-5.17, p<0.001), and highest quintile hs CRP (OR=1.54, CI; 1.12-2.18,p=0.008) were independent predictors of ACh induced CAS. However, there was no difference in clinical outcomes up to 12 months. Conclusion: In conclusion, higher hs CRP was associated with higher incidence of CAS, worse angiographic characteristics and ischemic EKG change, but was not associated with clinical outcomes. [ABSTRACT FROM AUTHOR] |
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| Items | – Name: Title Label: Title Group: Ti Data: The Impact of High Sensitivity C-Reactive Protein Level on Coronary Artery Spasm as Assessed by Intracoronary Acetylcholine Provocation Test. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ji+Young+Park%22">Ji Young Park</searchLink><br /><searchLink fieldCode="AR" term="%22Seung-Woon+Rha%22">Seung-Woon Rha</searchLink><br /><searchLink fieldCode="AR" term="%22Yong-Jian+Li%22">Yong-Jian Li</searchLink><br /><searchLink fieldCode="AR" term="%22Kang-Yin+Chen%22">Kang-Yin Chen</searchLink><br /><searchLink fieldCode="AR" term="%22Byoung+Geol+Choi%22">Byoung Geol Choi</searchLink><br /><searchLink fieldCode="AR" term="%22Se+Yeon+Choi%22">Se Yeon Choi</searchLink><br /><searchLink fieldCode="AR" term="%22Sung+Kee+Ryu%22">Sung Kee Ryu</searchLink><br /><searchLink fieldCode="AR" term="%22Jae+Woong+Choi%22">Jae Woong Choi</searchLink><br /><searchLink fieldCode="AR" term="%22Tae+Kyun+Kim%22">Tae Kyun Kim</searchLink><br /><searchLink fieldCode="AR" term="%22Jeong+Min+Kim%22">Jeong Min Kim</searchLink><br /><searchLink fieldCode="AR" term="%22Yoon+Suk+Bak%22">Yoon Suk Bak</searchLink><br /><searchLink fieldCode="AR" term="%22Jae+Hoon+Lee%22">Jae Hoon Lee</searchLink><br /><searchLink fieldCode="AR" term="%22Sung+Il+Im%22">Sung Il Im</searchLink><br /><searchLink fieldCode="AR" term="%22Sun+Won+Kim%22">Sun Won Kim</searchLink><br /><searchLink fieldCode="AR" term="%22Jin+Oh+Na%22">Jin Oh Na</searchLink><br /><searchLink fieldCode="AR" term="%22Cheol+Ung+Choi%22">Cheol Ung Choi</searchLink><br /><searchLink fieldCode="AR" term="%22Hong+Euy+Lim%22">Hong Euy Lim</searchLink><br /><searchLink fieldCode="AR" term="%22Jin+Won+Kim%22">Jin Won Kim</searchLink><br /><searchLink fieldCode="AR" term="%22Eung+Ju+Kim%22">Eung Ju Kim</searchLink><br /><searchLink fieldCode="AR" term="%22Chang+Gyu+Park%22">Chang Gyu Park</searchLink> – Name: TitleSource Label: Source Group: Src Data: Yonsei Medical Journal; Nov2013, Vol. 54 Issue 6, p1299-1304, 6p – Name: Abstract Label: Abstract Group: Ab Data: Purpose: High sensitive C-reactive protein (hs CRP) is well known as a strong risk factor of cardiovascular disease (CVD). The aim of this study is to evaluate the impact of elevated hs CRP on coronary artery spasm (CAS) as assessed by in-tracoronary acetylcholine (ACh) provocation test. Materials and Methods: A total of 1729 consecutive patients without significant CVD who underwent coronary angiography and intracoronary ACh test between November 2004 and August 2010 were analyzed. The patients were divided into five groups according to quintiles of hs CRP levels. Results: At baseline, the prevalence of elderly, hypertension, diabetes mellitus, current smoking, and lipid levels were higher in patients with higher hs CRP. During ACh test, the incidences of significant CAS, ischemic elec-trocardiography (EKG) change, multivessel, and diffuse CAS were higher in patients with higher hs CRP. Multivariate analysis showed that the old age (OR=1.01, CI; 1.0-1.02,p=0.0226), myocardial bridge (OR=3.34, CI; 2.16-5.17, p<0.001), and highest quintile hs CRP (OR=1.54, CI; 1.12-2.18,p=0.008) were independent predictors of ACh induced CAS. However, there was no difference in clinical outcomes up to 12 months. Conclusion: In conclusion, higher hs CRP was associated with higher incidence of CAS, worse angiographic characteristics and ischemic EKG change, but was not associated with clinical outcomes. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Yonsei Medical Journal is the property of Yonsei University College of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3349/ymj.2013.54.6.1299 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 1299 Titles: – TitleFull: The Impact of High Sensitivity C-Reactive Protein Level on Coronary Artery Spasm as Assessed by Intracoronary Acetylcholine Provocation Test. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ji Young Park – PersonEntity: Name: NameFull: Seung-Woon Rha – PersonEntity: Name: NameFull: Yong-Jian Li – PersonEntity: Name: NameFull: Kang-Yin Chen – PersonEntity: Name: NameFull: Byoung Geol Choi – PersonEntity: Name: NameFull: Se Yeon Choi – PersonEntity: Name: NameFull: Sung Kee Ryu – PersonEntity: Name: NameFull: Jae Woong Choi – PersonEntity: Name: NameFull: Tae Kyun Kim – PersonEntity: Name: NameFull: Jeong Min Kim – PersonEntity: Name: NameFull: Yoon Suk Bak – PersonEntity: Name: NameFull: Jae Hoon Lee – PersonEntity: Name: NameFull: Sung Il Im – PersonEntity: Name: NameFull: Sun Won Kim – PersonEntity: Name: NameFull: Jin Oh Na – PersonEntity: Name: NameFull: Cheol Ung Choi – PersonEntity: Name: NameFull: Hong Euy Lim – PersonEntity: Name: NameFull: Jin Won Kim – PersonEntity: Name: NameFull: Eung Ju Kim – PersonEntity: Name: NameFull: Chang Gyu Park IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2013 Type: published Y: 2013 Identifiers: – Type: issn-print Value: 05135796 Numbering: – Type: volume Value: 54 – Type: issue Value: 6 Titles: – TitleFull: Yonsei Medical Journal Type: main |
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