Academic Journal
View in EDS

Baseline urinary osteopontin levels are associated with the improvement of metabolic syndrome.

Bibliographic Details
Title: Baseline urinary osteopontin levels are associated with the improvement of metabolic syndrome.
Authors: Moriero, Margherita, Verzola, Daniela, Bertolotto, Maria, Minetti, Silvia, Contini, Paola, Ramoni, Davide, Liberale, Luca, Pontremoli, Roberto, Viazzi, Francesca, Pende, Aldo, Pisciotta, Livia, Montecucco, Fabrizio, Carbone, Federico
Source: Nutrition, Metabolism & Cardiovascular Diseases; Aug2024, Vol. 34 Issue 8, p1874-1878, 5p
Abstract: While serum osteopontin (OPN)'s established role in cardiometabolic risk is recognized, its potential as a predictor of metabolic syndrome (MetS) improvement through a urine assay has not yet been demonstrated. In this study, we propose its potential predictive role over a 12-month period of standard care, with the ability to complement anthropometric measures. Hierarchical clustering revealed a notable association of urinary OPN (uOPN) with MetS criteria and overcame anthropometric measures in predicting the improvement at 12 months (OR of 2.74 [95% CI 1.32 to 6.29]). uOPN significantly contributed to the homogeneity of the nodes in the random forest and ultimately enhanced the performance of anthropometric measures when assessed for accuracy and area under the curve (AUC). Our findings offer insights into potential applications in cardiometabolic medicine for uOPN, which is easily detectable in non-invasive biological samples through an affordable assay. • Cardiometabolic diseases are linked with aging process. • Osteopontin has an established role in Cardiometabolic risk, but not when assayed in urine. • Osteopontin has a potential as predictor of metabolic syndrome improvement over 12 months of standard of care. • Osteopontin may improve the accuracy of anthropometric measure in defining cardiometabolic risk. [ABSTRACT FROM AUTHOR]
Copyright of Nutrition, Metabolism & Cardiovascular Diseases is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Supplemental Index
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://www.doi.org/10.1016/j.numecd.2024.03.028?
    Name: ScienceDirect (all content)-s8985755
    Category: fullText
    Text: View record from ScienceDirect
    MouseOverText: View record from ScienceDirect
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edo&genre=article&issn=09394753&ISBN=&volume=34&issue=8&date=20240801&spage=1874&pages=1874-1878&title=Nutrition, Metabolism & Cardiovascular Diseases&atitle=Baseline%20urinary%20osteopontin%20levels%20are%20associated%20with%20the%20improvement%20of%20metabolic%20syndrome.&aulast=Moriero%2C%20Margherita&id=DOI:10.1016/j.numecd.2024.03.028
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
Header DbId: edo
DbLabel: Supplemental Index
An: 178334434
RelevancyScore: 1041
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 1040.51647949219
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Baseline urinary osteopontin levels are associated with the improvement of metabolic syndrome.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Moriero%2C+Margherita%22">Moriero, Margherita</searchLink><br /><searchLink fieldCode="AR" term="%22Verzola%2C+Daniela%22">Verzola, Daniela</searchLink><br /><searchLink fieldCode="AR" term="%22Bertolotto%2C+Maria%22">Bertolotto, Maria</searchLink><br /><searchLink fieldCode="AR" term="%22Minetti%2C+Silvia%22">Minetti, Silvia</searchLink><br /><searchLink fieldCode="AR" term="%22Contini%2C+Paola%22">Contini, Paola</searchLink><br /><searchLink fieldCode="AR" term="%22Ramoni%2C+Davide%22">Ramoni, Davide</searchLink><br /><searchLink fieldCode="AR" term="%22Liberale%2C+Luca%22">Liberale, Luca</searchLink><br /><searchLink fieldCode="AR" term="%22Pontremoli%2C+Roberto%22">Pontremoli, Roberto</searchLink><br /><searchLink fieldCode="AR" term="%22Viazzi%2C+Francesca%22">Viazzi, Francesca</searchLink><br /><searchLink fieldCode="AR" term="%22Pende%2C+Aldo%22">Pende, Aldo</searchLink><br /><searchLink fieldCode="AR" term="%22Pisciotta%2C+Livia%22">Pisciotta, Livia</searchLink><br /><searchLink fieldCode="AR" term="%22Montecucco%2C+Fabrizio%22">Montecucco, Fabrizio</searchLink><br /><searchLink fieldCode="AR" term="%22Carbone%2C+Federico%22">Carbone, Federico</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: Nutrition, Metabolism & Cardiovascular Diseases; Aug2024, Vol. 34 Issue 8, p1874-1878, 5p
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: While serum osteopontin (OPN)'s established role in cardiometabolic risk is recognized, its potential as a predictor of metabolic syndrome (MetS) improvement through a urine assay has not yet been demonstrated. In this study, we propose its potential predictive role over a 12-month period of standard care, with the ability to complement anthropometric measures. Hierarchical clustering revealed a notable association of urinary OPN (uOPN) with MetS criteria and overcame anthropometric measures in predicting the improvement at 12 months (OR of 2.74 [95% CI 1.32 to 6.29]). uOPN significantly contributed to the homogeneity of the nodes in the random forest and ultimately enhanced the performance of anthropometric measures when assessed for accuracy and area under the curve (AUC). Our findings offer insights into potential applications in cardiometabolic medicine for uOPN, which is easily detectable in non-invasive biological samples through an affordable assay. • Cardiometabolic diseases are linked with aging process. • Osteopontin has an established role in Cardiometabolic risk, but not when assayed in urine. • Osteopontin has a potential as predictor of metabolic syndrome improvement over 12 months of standard of care. • Osteopontin may improve the accuracy of anthropometric measure in defining cardiometabolic risk. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Nutrition, Metabolism & Cardiovascular Diseases is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edo&AN=178334434
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.numecd.2024.03.028
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 5
        StartPage: 1874
    Titles:
      – TitleFull: Baseline urinary osteopontin levels are associated with the improvement of metabolic syndrome.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Moriero, Margherita
      – PersonEntity:
          Name:
            NameFull: Verzola, Daniela
      – PersonEntity:
          Name:
            NameFull: Bertolotto, Maria
      – PersonEntity:
          Name:
            NameFull: Minetti, Silvia
      – PersonEntity:
          Name:
            NameFull: Contini, Paola
      – PersonEntity:
          Name:
            NameFull: Ramoni, Davide
      – PersonEntity:
          Name:
            NameFull: Liberale, Luca
      – PersonEntity:
          Name:
            NameFull: Pontremoli, Roberto
      – PersonEntity:
          Name:
            NameFull: Viazzi, Francesca
      – PersonEntity:
          Name:
            NameFull: Pende, Aldo
      – PersonEntity:
          Name:
            NameFull: Pisciotta, Livia
      – PersonEntity:
          Name:
            NameFull: Montecucco, Fabrizio
      – PersonEntity:
          Name:
            NameFull: Carbone, Federico
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 08
              Text: Aug2024
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-print
              Value: 09394753
          Numbering:
            – Type: volume
              Value: 34
            – Type: issue
              Value: 8
          Titles:
            – TitleFull: Nutrition, Metabolism & Cardiovascular Diseases
              Type: main
ResultId 1