Be vigilant for skin manifestations of inherited cancer syndromes.
| Title: | Be vigilant for skin manifestations of inherited cancer syndromes. |
|---|---|
| Authors: | Tidman, Alice S. M., Tidman, Alice SM |
| Source: | Practitioner; Jan2017, Vol. 261 Issue 1800, p23-27, 5p |
| Subject Terms: | CANCER, SYNDROMES, TUMORS, TISSUE wounds, SKIN diseases, LENTIGO, EPIDERMAL cyst, SMOOTH muscle tumors |
| Abstract: | More than 200 hereditary cancer susceptibility syndromes have been described, and it is thought that they account for 5-10% of all cancers. Many have dermatological manifestations (usually lesions, occasionally rashes) which frequently precede other systemic pathology. Dermatological signs are usually non-specific and often trivial in appearance, making their significance easy to overlook and a clinical diagnosis challenging. Histological examination is often required to differentiate lesions. They are usually benign and pathologically unrelated to the primary tumours, with the exception of the atypical moles of the dysplastic naevus syndrome, and may present simply as a cosmetic problem for the patient. However, a number of cancer syndromes exhibit an increased risk of developing malignant skin lesions. For instance, Gorlin syndrome (nevoid basal cell carcinoma syndrome) which typically results in the development of multiple basal cell carcinomas, within the first few decades of life. The majority of cancer syndromes with skin signs are inherited in an autosomal dominant pattern demonstrating complete penetrance before the age of 70. Once a cancer syndrome has been diagnosed, the cornerstone of management is frequent surveillance for the early detection and treatment of malignancy. Genetic testing and counselling should be offered to family members. [ABSTRACT FROM AUTHOR] |
| Copyright of Practitioner is the property of Practitioner Medical Publishing Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Supplemental Index |
| FullText | Text: Availability: 0 CustomLinks: – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edo&genre=article&issn=00326518&ISBN=&volume=261&issue=1800&date=20170101&spage=23&pages=23-27&title=Practitioner&atitle=Be%20vigilant%20for%20skin%20manifestations%20of%20inherited%20cancer%20syndromes.&aulast=Tidman%2C%20Alice%20S.%20M.&id=DOI: Name: Full Text Finder (for New FTF UI) (s8985755) Category: fullText Text: Find It @ SCU Libraries MouseOverText: Find It @ SCU Libraries |
|---|---|
| Header | DbId: edo DbLabel: Supplemental Index An: 121085558 RelevancyScore: 861 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 861.337585449219 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Be vigilant for skin manifestations of inherited cancer syndromes. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Tidman%2C+Alice+S%2E+M%2E%22">Tidman, Alice S. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Tidman%2C+Alice+SM%22">Tidman, Alice SM</searchLink> – Name: TitleSource Label: Source Group: Src Data: Practitioner; Jan2017, Vol. 261 Issue 1800, p23-27, 5p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22CANCER%22">CANCER</searchLink><br /><searchLink fieldCode="DE" term="%22SYNDROMES%22">SYNDROMES</searchLink><br /><searchLink fieldCode="DE" term="%22TUMORS%22">TUMORS</searchLink><br /><searchLink fieldCode="DE" term="%22TISSUE+wounds%22">TISSUE wounds</searchLink><br /><searchLink fieldCode="DE" term="%22SKIN+diseases%22">SKIN diseases</searchLink><br /><searchLink fieldCode="DE" term="%22LENTIGO%22">LENTIGO</searchLink><br /><searchLink fieldCode="DE" term="%22EPIDERMAL+cyst%22">EPIDERMAL cyst</searchLink><br /><searchLink fieldCode="DE" term="%22SMOOTH+muscle+tumors%22">SMOOTH muscle tumors</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: More than 200 hereditary cancer susceptibility syndromes have been described, and it is thought that they account for 5-10% of all cancers. Many have dermatological manifestations (usually lesions, occasionally rashes) which frequently precede other systemic pathology. Dermatological signs are usually non-specific and often trivial in appearance, making their significance easy to overlook and a clinical diagnosis challenging. Histological examination is often required to differentiate lesions. They are usually benign and pathologically unrelated to the primary tumours, with the exception of the atypical moles of the dysplastic naevus syndrome, and may present simply as a cosmetic problem for the patient. However, a number of cancer syndromes exhibit an increased risk of developing malignant skin lesions. For instance, Gorlin syndrome (nevoid basal cell carcinoma syndrome) which typically results in the development of multiple basal cell carcinomas, within the first few decades of life. The majority of cancer syndromes with skin signs are inherited in an autosomal dominant pattern demonstrating complete penetrance before the age of 70. Once a cancer syndrome has been diagnosed, the cornerstone of management is frequent surveillance for the early detection and treatment of malignancy. Genetic testing and counselling should be offered to family members. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Practitioner is the property of Practitioner Medical Publishing Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edo&AN=121085558 |
| RecordInfo | BibRecord: BibEntity: Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 23 Subjects: – SubjectFull: CANCER Type: general – SubjectFull: SYNDROMES Type: general – SubjectFull: TUMORS Type: general – SubjectFull: TISSUE wounds Type: general – SubjectFull: SKIN diseases Type: general – SubjectFull: LENTIGO Type: general – SubjectFull: EPIDERMAL cyst Type: general – SubjectFull: SMOOTH muscle tumors Type: general Titles: – TitleFull: Be vigilant for skin manifestations of inherited cancer syndromes. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Tidman, Alice S. M. – PersonEntity: Name: NameFull: Tidman, Alice SM IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2017 Type: published Y: 2017 Identifiers: – Type: issn-print Value: 00326518 Numbering: – Type: volume Value: 261 – Type: issue Value: 1800 Titles: – TitleFull: Practitioner Type: main |
| ResultId | 1 |