Factors influencing the size distribution of aerosols from jet nebulisers.
| Title: | Factors influencing the size distribution of aerosols from jet nebulisers. |
|---|---|
| Authors: | Clay, M M, Pavia, D, Newman, S P, Clarke, S W |
| Source: | Thorax; Oct1983, Vol. 38 Issue 10, p755-759, 5p, 1 Chart, 3 Graphs |
| Abstract: | The size distribution of saline and bronchodilator (terbutaline) aerosol droplets generated from four widely used jet nebulisers (Acorn, Upmist, Turret, and Inspiron Mini-neb) has been measured with a Malvern 2200 Laser Particle Sizer. The mass median diameter of aerosol droplets generated by each nebuliser was strongly influenced by the driving flow rate of compressed air. By increasing the flow rate from 4 to 8 1 min-1 mass median diameters were halved (p less than 0.01) and there was an increase in the mass of aerosol within the optimum respirable range (less than 5 micron). To achieve this range the following individual flow rates were required: Turret 4 1 min-1, Acorn and Upmist 6 1 min-1, and Inspiron Mini-neb 8 1 min-1. A significant inverse relation (p less than 0.001) was found between mass median diameter and the geometric standard deviation, indicating that the aerosols were smaller but more heterodisperse at high flow rates. Changes in drug concentration had little effect on aerosol size. In 72% of the nebulisations followed to dryness there was no significant change in mass median diameter during the course of nebulisation and in the remainder it was less than 1.3 micron. [ABSTRACT FROM AUTHOR] |
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| Database: | Complementary Index |
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| Items | – Name: Title Label: Title Group: Ti Data: Factors influencing the size distribution of aerosols from jet nebulisers. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Clay%2C+M+M%22">Clay, M M</searchLink><br /><searchLink fieldCode="AR" term="%22Pavia%2C+D%22">Pavia, D</searchLink><br /><searchLink fieldCode="AR" term="%22Newman%2C+S+P%22">Newman, S P</searchLink><br /><searchLink fieldCode="AR" term="%22Clarke%2C+S+W%22">Clarke, S W</searchLink> – Name: TitleSource Label: Source Group: Src Data: Thorax; Oct1983, Vol. 38 Issue 10, p755-759, 5p, 1 Chart, 3 Graphs – Name: Abstract Label: Abstract Group: Ab Data: The size distribution of saline and bronchodilator (terbutaline) aerosol droplets generated from four widely used jet nebulisers (Acorn, Upmist, Turret, and Inspiron Mini-neb) has been measured with a Malvern 2200 Laser Particle Sizer. The mass median diameter of aerosol droplets generated by each nebuliser was strongly influenced by the driving flow rate of compressed air. By increasing the flow rate from 4 to 8 1 min-1 mass median diameters were halved (p less than 0.01) and there was an increase in the mass of aerosol within the optimum respirable range (less than 5 micron). To achieve this range the following individual flow rates were required: Turret 4 1 min-1, Acorn and Upmist 6 1 min-1, and Inspiron Mini-neb 8 1 min-1. A significant inverse relation (p less than 0.001) was found between mass median diameter and the geometric standard deviation, indicating that the aerosols were smaller but more heterodisperse at high flow rates. Changes in drug concentration had little effect on aerosol size. In 72% of the nebulisations followed to dryness there was no significant change in mass median diameter during the course of nebulisation and in the remainder it was less than 1.3 micron. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Thorax is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 755 Titles: – TitleFull: Factors influencing the size distribution of aerosols from jet nebulisers. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Clay, M M – PersonEntity: Name: NameFull: Pavia, D – PersonEntity: Name: NameFull: Newman, S P – PersonEntity: Name: NameFull: Clarke, S W IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct1983 Type: published Y: 1983 Identifiers: – Type: issn-print Value: 00406376 Numbering: – Type: volume Value: 38 – Type: issue Value: 10 Titles: – TitleFull: Thorax Type: main |
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