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Characterization of the Gene BmEm4, a Homologue of Drosophila E(spl)m4, from the Silkworm, Bombyx mori.

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Title: Characterization of the Gene BmEm4, a Homologue of Drosophila E(spl)m4, from the Silkworm, Bombyx mori.
Authors: Fenghui Zeng, Hongxia Xie, Zuoming Nie, Jian Chen, Zhengbing Lv, Jianqing Chen, Dan Wang, Lili Liu, Wei Yu, Qing Sheng, Xiangfu Wu, Yaozhou Zhang
Source: Comparative & Functional Genomics; 2009, Special section p1-12, 12p, 2 Color Photographs, 1 Black and White Photograph, 3 Diagrams, 2 Graphs
Subject Terms: DROSOPHILA, DEVELOPMENTAL neurobiology, GENES, PROTEINS, SILKWORMS
Abstract: The Drosophila E(spl)m4 gene contains some highly conserved motifs (such as the Brd box, GY box, K box, and CAAC motif) in its 3′ untranslated region (3′UTR). It was shown to be a microRNA target gene in Drosophila and to play an important role in the regulation of neurogenesis. We identified a homologue of the E(spl)m4 gene from Bombyx mori called BmEm4 and examined the expression patterns of BmEm4 mRNA and protein. There was a lack of correlation in the expression of the mRNA and protein between the different developmental stages, which raises the possibility of posttranscriptional regulation of the BmEm4 mRNA. Consistent with this idea is the finding that the 3′ UTR contains two putative binding sites for microRNAs. Moreover, given that the expression is the highest in the larval head, as confirmed by immunohistochemistry, we propose that BmEm4 may also be involved in the regulation of neurogenesis. Immunostaining indicated that BmEm4 is located primarily in the cytoplasm. [ABSTRACT FROM AUTHOR]
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Characterization of the Gene BmEm4, a Homologue of Drosophila E(spl)m4, from the Silkworm, Bombyx mori.
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  Data: <searchLink fieldCode="AR" term="%22Fenghui+Zeng%22">Fenghui Zeng</searchLink><br /><searchLink fieldCode="AR" term="%22Hongxia+Xie%22">Hongxia Xie</searchLink><br /><searchLink fieldCode="AR" term="%22Zuoming+Nie%22">Zuoming Nie</searchLink><br /><searchLink fieldCode="AR" term="%22Jian+Chen%22">Jian Chen</searchLink><br /><searchLink fieldCode="AR" term="%22Zhengbing+Lv%22">Zhengbing Lv</searchLink><br /><searchLink fieldCode="AR" term="%22Jianqing+Chen%22">Jianqing Chen</searchLink><br /><searchLink fieldCode="AR" term="%22Dan+Wang%22">Dan Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Lili+Liu%22">Lili Liu</searchLink><br /><searchLink fieldCode="AR" term="%22Wei+Yu%22">Wei Yu</searchLink><br /><searchLink fieldCode="AR" term="%22Qing+Sheng%22">Qing Sheng</searchLink><br /><searchLink fieldCode="AR" term="%22Xiangfu+Wu%22">Xiangfu Wu</searchLink><br /><searchLink fieldCode="AR" term="%22Yaozhou+Zhang%22">Yaozhou Zhang</searchLink>
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  Data: Comparative & Functional Genomics; 2009, Special section p1-12, 12p, 2 Color Photographs, 1 Black and White Photograph, 3 Diagrams, 2 Graphs
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  Data: <searchLink fieldCode="DE" term="%22DROSOPHILA%22">DROSOPHILA</searchLink><br /><searchLink fieldCode="DE" term="%22DEVELOPMENTAL+neurobiology%22">DEVELOPMENTAL neurobiology</searchLink><br /><searchLink fieldCode="DE" term="%22GENES%22">GENES</searchLink><br /><searchLink fieldCode="DE" term="%22PROTEINS%22">PROTEINS</searchLink><br /><searchLink fieldCode="DE" term="%22SILKWORMS%22">SILKWORMS</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The Drosophila E(spl)m4 gene contains some highly conserved motifs (such as the Brd box, GY box, K box, and CAAC motif) in its 3′ untranslated region (3′UTR). It was shown to be a microRNA target gene in Drosophila and to play an important role in the regulation of neurogenesis. We identified a homologue of the E(spl)m4 gene from Bombyx mori called BmEm4 and examined the expression patterns of BmEm4 mRNA and protein. There was a lack of correlation in the expression of the mRNA and protein between the different developmental stages, which raises the possibility of posttranscriptional regulation of the BmEm4 mRNA. Consistent with this idea is the finding that the 3′ UTR contains two putative binding sites for microRNAs. Moreover, given that the expression is the highest in the larval head, as confirmed by immunohistochemistry, we propose that BmEm4 may also be involved in the regulation of neurogenesis. Immunostaining indicated that BmEm4 is located primarily in the cytoplasm. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Comparative & Functional Genomics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1155/2009/947490
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      – Code: eng
        Text: English
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        PageCount: 12
        StartPage: 1
    Subjects:
      – SubjectFull: DROSOPHILA
        Type: general
      – SubjectFull: DEVELOPMENTAL neurobiology
        Type: general
      – SubjectFull: GENES
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      – SubjectFull: PROTEINS
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      – TitleFull: Characterization of the Gene BmEm4, a Homologue of Drosophila E(spl)m4, from the Silkworm, Bombyx mori.
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              Text: 2009
              Type: published
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