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Fre-2, A LOCUS CLOSELY LINKED TO Fv-2, IS REARRANGED IN SOME ERYTHROLEUKEMIAS INDUCED BY FRIEND MURINE LEUKEMIA VIRUS.

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Title: Fre-2, A LOCUS CLOSELY LINKED TO Fv-2, IS REARRANGED IN SOME ERYTHROLEUKEMIAS INDUCED BY FRIEND MURINE LEUKEMIA VIRUS.
Authors: EISEL, Dirk, VEIT, Markus, FRIEDRICH, Ursula, PASS, Maria, SELS, Franz T., Friedrich, Roland W.
Source: Leukemia (08876924); Apr97 Supplement 3, Vol. 11, p155-159, 5p
Subject Terms: MOUSE leukemia viruses, FRIEND virus, LEUKEMIA, CANCER genes, SPLEEN, MESSENGER RNA
Abstract: Friend murine leukemia virus (F-MuLV) induces leukemia by integration into the cellular genome, thereby changing the structure of expression of cellular oncogenes. Here we describe a new F-MuLV integration site Fre-2 isolated from splenic DNA of an erythroleukemic animal. This site has been found rearranged in 5 out of 63 additional tumors; however, no F-MuLV proviruses could be detected in the vicinity of the rearrangement sites in these 5 cases. The rearrangements represented closely clustered chromosomal breakpoints, presumably chromosomal translocations. Exons transcribed into differentially spliced mRNAs of 1.9 and 3.7 kb have been found near the breakpoint. No sequences that are homologous to Fre-2 could be found in databases. [ABSTRACT FROM AUTHOR]
Copyright of Leukemia (08876924) is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Complementary Index
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  Data: Fre-2, A LOCUS CLOSELY LINKED TO Fv-2, IS REARRANGED IN SOME ERYTHROLEUKEMIAS INDUCED BY FRIEND MURINE LEUKEMIA VIRUS.
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  Data: <searchLink fieldCode="AR" term="%22EISEL%2C+Dirk%22">EISEL, Dirk</searchLink><br /><searchLink fieldCode="AR" term="%22VEIT%2C+Markus%22">VEIT, Markus</searchLink><br /><searchLink fieldCode="AR" term="%22FRIEDRICH%2C+Ursula%22">FRIEDRICH, Ursula</searchLink><br /><searchLink fieldCode="AR" term="%22PASS%2C+Maria%22">PASS, Maria</searchLink><br /><searchLink fieldCode="AR" term="%22SELS%2C+Franz+T%2E%22">SELS, Franz T.</searchLink><br /><searchLink fieldCode="AR" term="%22Friedrich%2C+Roland+W%2E%22">Friedrich, Roland W.</searchLink>
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  Data: Leukemia (08876924); Apr97 Supplement 3, Vol. 11, p155-159, 5p
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22MOUSE+leukemia+viruses%22">MOUSE leukemia viruses</searchLink><br /><searchLink fieldCode="DE" term="%22FRIEND+virus%22">FRIEND virus</searchLink><br /><searchLink fieldCode="DE" term="%22LEUKEMIA%22">LEUKEMIA</searchLink><br /><searchLink fieldCode="DE" term="%22CANCER+genes%22">CANCER genes</searchLink><br /><searchLink fieldCode="DE" term="%22SPLEEN%22">SPLEEN</searchLink><br /><searchLink fieldCode="DE" term="%22MESSENGER+RNA%22">MESSENGER RNA</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Friend murine leukemia virus (F-MuLV) induces leukemia by integration into the cellular genome, thereby changing the structure of expression of cellular oncogenes. Here we describe a new F-MuLV integration site Fre-2 isolated from splenic DNA of an erythroleukemic animal. This site has been found rearranged in 5 out of 63 additional tumors; however, no F-MuLV proviruses could be detected in the vicinity of the rearrangement sites in these 5 cases. The rearrangements represented closely clustered chromosomal breakpoints, presumably chromosomal translocations. Exons transcribed into differentially spliced mRNAs of 1.9 and 3.7 kb have been found near the breakpoint. No sequences that are homologous to Fre-2 could be found in databases. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Leukemia (08876924) is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Code: eng
        Text: English
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        PageCount: 5
        StartPage: 155
    Subjects:
      – SubjectFull: MOUSE leukemia viruses
        Type: general
      – SubjectFull: FRIEND virus
        Type: general
      – SubjectFull: LEUKEMIA
        Type: general
      – SubjectFull: CANCER genes
        Type: general
      – SubjectFull: SPLEEN
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      – SubjectFull: MESSENGER RNA
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      – TitleFull: Fre-2, A LOCUS CLOSELY LINKED TO Fv-2, IS REARRANGED IN SOME ERYTHROLEUKEMIAS INDUCED BY FRIEND MURINE LEUKEMIA VIRUS.
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            NameFull: VEIT, Markus
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            NameFull: FRIEDRICH, Ursula
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            NameFull: PASS, Maria
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            NameFull: SELS, Franz T.
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            – D: 03
              M: 04
              Text: Apr97 Supplement 3
              Type: published
              Y: 1997
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            – Type: issn-print
              Value: 08876924
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              Value: 11
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            – TitleFull: Leukemia (08876924)
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