Academic Journal
View in EDS

No reduced serum serotonin levels in patients with post-acute sequelae of COVID-19.

Bibliographic Details
Title: No reduced serum serotonin levels in patients with post-acute sequelae of COVID-19.
Authors: Mathé, Philipp, Götz, Veronika, Stete, Katarina, Walzer, Dietrich, Hilger, Hanna, Pfau, Stefanie, Hofmann, Maike, Rieg, Siegbert, Kern, Winfried V.
Source: Infection; Feb2025, Vol. 53 Issue 1, p463-466, 4p
Subject Terms: OUTPATIENT services in hospitals, LIQUID chromatography-mass spectrometry, POST-acute COVID-19 syndrome, POLYMERASE chain reaction, FATIGUE (Physiology), RETROSPECTIVE studies, INFECTION, SEVERITY of illness index, LONGITUDINAL method, MEDICAL records, ACQUISITION of data, SEROTONIN, BIOMARKERS, MENTAL depression
Abstract: Purpose: Approximately 10–20% of patients previously infected with SARS-CoV-2 experience post-acute sequelae of COVID-19 (PASC), presenting with fatigue and neurocognitive dysfunction along various other symptoms. Recent studies suggested a possible role of a virally induced decrease in peripheral serotonin concentration in the pathogenesis of PASC. We set out to verify this finding in an independent and well-defined cohort of PASC patients from our post-COVID-19 outpatient clinic. Methods: We performed a retrospective case–control study including 34 confirmed PASC patients and 14 healthy controls. Clinical assessment encompassed physician examination as well as questionnaire based evaluation. Eligibility required ongoing symptoms for at least 6 months post-PCR-confirmed infection, relevant fatigue (CFS ≥ 4), and no other medical conditions. Serum serotonin was determined by LC–MS/MS technique. Results: Serum serotonin levels in PASC patients did not significantly differ from healthy controls. Most subjects had normal serotonin levels, with no subnormal readings. Subgroup analyses showed no significant differences in serotonin levels based according to predominant fatigue type, high overall fatigue score or depression severity. Conclusion: We postulate that peripheral serotonin is no reliable biomarker for PASC and that it should not be used in routine diagnostic. Therapy of PASC with serotonin-reuptake inhibitors or tryptophane supplementation should not be based solely on the assumption of lowered serotonin levels. [ABSTRACT FROM AUTHOR]
Copyright of Infection is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Complementary Index
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edb&genre=article&issn=03008126&ISBN=&volume=53&issue=1&date=20250201&spage=463&pages=463-466&title=Infection&atitle=No%20reduced%20serum%20serotonin%20levels%20in%20patients%20with%20post-acute%20sequelae%20of%20COVID-19.&aulast=Math%C3%A9%2C%20Philipp&id=DOI:10.1007/s15010-024-02397-5
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
Header DbId: edb
DbLabel: Complementary Index
An: 183079928
RelevancyScore: 1082
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 1082.12268066406
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: No reduced serum serotonin levels in patients with post-acute sequelae of COVID-19.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Mathé%2C+Philipp%22">Mathé, Philipp</searchLink><br /><searchLink fieldCode="AR" term="%22Götz%2C+Veronika%22">Götz, Veronika</searchLink><br /><searchLink fieldCode="AR" term="%22Stete%2C+Katarina%22">Stete, Katarina</searchLink><br /><searchLink fieldCode="AR" term="%22Walzer%2C+Dietrich%22">Walzer, Dietrich</searchLink><br /><searchLink fieldCode="AR" term="%22Hilger%2C+Hanna%22">Hilger, Hanna</searchLink><br /><searchLink fieldCode="AR" term="%22Pfau%2C+Stefanie%22">Pfau, Stefanie</searchLink><br /><searchLink fieldCode="AR" term="%22Hofmann%2C+Maike%22">Hofmann, Maike</searchLink><br /><searchLink fieldCode="AR" term="%22Rieg%2C+Siegbert%22">Rieg, Siegbert</searchLink><br /><searchLink fieldCode="AR" term="%22Kern%2C+Winfried+V%2E%22">Kern, Winfried V.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: Infection; Feb2025, Vol. 53 Issue 1, p463-466, 4p
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22OUTPATIENT+services+in+hospitals%22">OUTPATIENT services in hospitals</searchLink><br /><searchLink fieldCode="DE" term="%22LIQUID+chromatography-mass+spectrometry%22">LIQUID chromatography-mass spectrometry</searchLink><br /><searchLink fieldCode="DE" term="%22POST-acute+COVID-19+syndrome%22">POST-acute COVID-19 syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22POLYMERASE+chain+reaction%22">POLYMERASE chain reaction</searchLink><br /><searchLink fieldCode="DE" term="%22FATIGUE+%28Physiology%29%22">FATIGUE (Physiology)</searchLink><br /><searchLink fieldCode="DE" term="%22RETROSPECTIVE+studies%22">RETROSPECTIVE studies</searchLink><br /><searchLink fieldCode="DE" term="%22INFECTION%22">INFECTION</searchLink><br /><searchLink fieldCode="DE" term="%22SEVERITY+of+illness+index%22">SEVERITY of illness index</searchLink><br /><searchLink fieldCode="DE" term="%22LONGITUDINAL+method%22">LONGITUDINAL method</searchLink><br /><searchLink fieldCode="DE" term="%22MEDICAL+records%22">MEDICAL records</searchLink><br /><searchLink fieldCode="DE" term="%22ACQUISITION+of+data%22">ACQUISITION of data</searchLink><br /><searchLink fieldCode="DE" term="%22SEROTONIN%22">SEROTONIN</searchLink><br /><searchLink fieldCode="DE" term="%22BIOMARKERS%22">BIOMARKERS</searchLink><br /><searchLink fieldCode="DE" term="%22MENTAL+depression%22">MENTAL depression</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: Approximately 10–20% of patients previously infected with SARS-CoV-2 experience post-acute sequelae of COVID-19 (PASC), presenting with fatigue and neurocognitive dysfunction along various other symptoms. Recent studies suggested a possible role of a virally induced decrease in peripheral serotonin concentration in the pathogenesis of PASC. We set out to verify this finding in an independent and well-defined cohort of PASC patients from our post-COVID-19 outpatient clinic. Methods: We performed a retrospective case–control study including 34 confirmed PASC patients and 14 healthy controls. Clinical assessment encompassed physician examination as well as questionnaire based evaluation. Eligibility required ongoing symptoms for at least 6 months post-PCR-confirmed infection, relevant fatigue (CFS ≥ 4), and no other medical conditions. Serum serotonin was determined by LC–MS/MS technique. Results: Serum serotonin levels in PASC patients did not significantly differ from healthy controls. Most subjects had normal serotonin levels, with no subnormal readings. Subgroup analyses showed no significant differences in serotonin levels based according to predominant fatigue type, high overall fatigue score or depression severity. Conclusion: We postulate that peripheral serotonin is no reliable biomarker for PASC and that it should not be used in routine diagnostic. Therapy of PASC with serotonin-reuptake inhibitors or tryptophane supplementation should not be based solely on the assumption of lowered serotonin levels. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Infection is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edb&AN=183079928
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s15010-024-02397-5
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 4
        StartPage: 463
    Subjects:
      – SubjectFull: OUTPATIENT services in hospitals
        Type: general
      – SubjectFull: LIQUID chromatography-mass spectrometry
        Type: general
      – SubjectFull: POST-acute COVID-19 syndrome
        Type: general
      – SubjectFull: POLYMERASE chain reaction
        Type: general
      – SubjectFull: FATIGUE (Physiology)
        Type: general
      – SubjectFull: RETROSPECTIVE studies
        Type: general
      – SubjectFull: INFECTION
        Type: general
      – SubjectFull: SEVERITY of illness index
        Type: general
      – SubjectFull: LONGITUDINAL method
        Type: general
      – SubjectFull: MEDICAL records
        Type: general
      – SubjectFull: ACQUISITION of data
        Type: general
      – SubjectFull: SEROTONIN
        Type: general
      – SubjectFull: BIOMARKERS
        Type: general
      – SubjectFull: MENTAL depression
        Type: general
    Titles:
      – TitleFull: No reduced serum serotonin levels in patients with post-acute sequelae of COVID-19.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Mathé, Philipp
      – PersonEntity:
          Name:
            NameFull: Götz, Veronika
      – PersonEntity:
          Name:
            NameFull: Stete, Katarina
      – PersonEntity:
          Name:
            NameFull: Walzer, Dietrich
      – PersonEntity:
          Name:
            NameFull: Hilger, Hanna
      – PersonEntity:
          Name:
            NameFull: Pfau, Stefanie
      – PersonEntity:
          Name:
            NameFull: Hofmann, Maike
      – PersonEntity:
          Name:
            NameFull: Rieg, Siegbert
      – PersonEntity:
          Name:
            NameFull: Kern, Winfried V.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 02
              Text: Feb2025
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-print
              Value: 03008126
          Numbering:
            – Type: volume
              Value: 53
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Infection
              Type: main
ResultId 1