Increased risk of genitourinary cancer in kidney transplant recipients: a large-scale national cohort study and its clinical implications.
| Title: | Increased risk of genitourinary cancer in kidney transplant recipients: a large-scale national cohort study and its clinical implications. |
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| Authors: | Kim, Hyunho, Chae, Kyung-Hee, Choi, Arum, Kim, Mi-hyeong, Hong, Ji Hyung, Choi, Bum Soon, Kim, Sukil, Ban, Tae Hyun |
| Source: | International Urology & Nephrology; Mar2025, Vol. 57 Issue 3, p715-722, 8p |
| Abstract: | Purpose: To investigate the risk of genitourinary (GU) cancer in kidney transplant recipients (KTRs) compared to that in the general population, focusing on potential risk factors and clinical implications. Methods: Using a national cohort of approximately 360,000 individuals, including 31,542 KTRs, we conducted a retrospective analysis of the data from 2007 to 2018. Propensity score matching was used to compare KTRs with a healthy population, adjusting for age, sex, diabetes, hypertension, and hypercholesterolemia. Results: We identified a significantly increased risk of GU cancers, particularly bladder and kidney cancers, in KTRs. Multivariate analysis revealed a higher risk of GU cancer associated with kidney transplantation [hazard ratio (HR) 2.133, 95% confidence interval (CI) 1.641–2.772] and hypercholesterolemia (HR 1.725, 95% CI 1.227–2.425), with older age and male sex also being significant risk factors. Conversely, no significant increase in prostate cancer risk was observed in KTRs compared to the general population. Conclusion: This national cohort-based study indicated an increased risk of GU cancer in KTRs, underscoring the need for targeted cancer surveillance and pre- and post-transplant counseling. These findings provide valuable insights for the development of cancer surveillance programs for KTRs and highlight the necessity for further research in this field. [ABSTRACT FROM AUTHOR] |
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| Database: | Complementary Index |
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| Items | – Name: Title Label: Title Group: Ti Data: Increased risk of genitourinary cancer in kidney transplant recipients: a large-scale national cohort study and its clinical implications. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kim%2C+Hyunho%22">Kim, Hyunho</searchLink><br /><searchLink fieldCode="AR" term="%22Chae%2C+Kyung-Hee%22">Chae, Kyung-Hee</searchLink><br /><searchLink fieldCode="AR" term="%22Choi%2C+Arum%22">Choi, Arum</searchLink><br /><searchLink fieldCode="AR" term="%22Kim%2C+Mi-hyeong%22">Kim, Mi-hyeong</searchLink><br /><searchLink fieldCode="AR" term="%22Hong%2C+Ji+Hyung%22">Hong, Ji Hyung</searchLink><br /><searchLink fieldCode="AR" term="%22Choi%2C+Bum+Soon%22">Choi, Bum Soon</searchLink><br /><searchLink fieldCode="AR" term="%22Kim%2C+Sukil%22">Kim, Sukil</searchLink><br /><searchLink fieldCode="AR" term="%22Ban%2C+Tae+Hyun%22">Ban, Tae Hyun</searchLink> – Name: TitleSource Label: Source Group: Src Data: International Urology & Nephrology; Mar2025, Vol. 57 Issue 3, p715-722, 8p – Name: Abstract Label: Abstract Group: Ab Data: Purpose: To investigate the risk of genitourinary (GU) cancer in kidney transplant recipients (KTRs) compared to that in the general population, focusing on potential risk factors and clinical implications. Methods: Using a national cohort of approximately 360,000 individuals, including 31,542 KTRs, we conducted a retrospective analysis of the data from 2007 to 2018. Propensity score matching was used to compare KTRs with a healthy population, adjusting for age, sex, diabetes, hypertension, and hypercholesterolemia. Results: We identified a significantly increased risk of GU cancers, particularly bladder and kidney cancers, in KTRs. Multivariate analysis revealed a higher risk of GU cancer associated with kidney transplantation [hazard ratio (HR) 2.133, 95% confidence interval (CI) 1.641–2.772] and hypercholesterolemia (HR 1.725, 95% CI 1.227–2.425), with older age and male sex also being significant risk factors. Conversely, no significant increase in prostate cancer risk was observed in KTRs compared to the general population. Conclusion: This national cohort-based study indicated an increased risk of GU cancer in KTRs, underscoring the need for targeted cancer surveillance and pre- and post-transplant counseling. These findings provide valuable insights for the development of cancer surveillance programs for KTRs and highlight the necessity for further research in this field. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of International Urology & Nephrology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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