Reply to: "Give Patients the Choice to Test for DPD Deficiency Before Fluoropyrimidine Chemotherapy," "Large-Scale DPD Testing Should Be More Than an Option," and "A Big Problem With a Feasible Solution, Not a Small Problem With a Complex Solution".

Bibliographic Details
Title: Reply to: "Give Patients the Choice to Test for DPD Deficiency Before Fluoropyrimidine Chemotherapy," "Large-Scale DPD Testing Should Be More Than an Option," and "A Big Problem With a Feasible Solution, Not a Small Problem With a Complex Solution".
Authors: Tamraz, Bani, Venook, Alan P.
Source: JCO Oncology Practice; Feb2025, Vol. 21 Issue 2, p265-266, 2p
Subject Terms: INBORN errors of metabolism, CANCER chemotherapy, PHARMACOGENOMICS, FLUOROURACIL, GENOTYPES, SINGLE nucleotide polymorphisms, PATIENTS' attitudes
Abstract: The article focuses on clarifying misunderstandings and responding to critiques of a previous editorial regarding DPYD genotyping and fluoropyrimidine-related toxicities. Topics include the complexity and limitations of current DPYD testing, the rare occurrence of absolute DPYD deficiency, and the importance of patient and clinician choice in testing decisions.
Database: Complementary Index
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IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Reply to: "Give Patients the Choice to Test for DPD Deficiency Before Fluoropyrimidine Chemotherapy," "Large-Scale DPD Testing Should Be More Than an Option," and "A Big Problem With a Feasible Solution, Not a Small Problem With a Complex Solution".
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Tamraz%2C+Bani%22">Tamraz, Bani</searchLink><br /><searchLink fieldCode="AR" term="%22Venook%2C+Alan+P%2E%22">Venook, Alan P.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: JCO Oncology Practice; Feb2025, Vol. 21 Issue 2, p265-266, 2p
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22INBORN+errors+of+metabolism%22">INBORN errors of metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22CANCER+chemotherapy%22">CANCER chemotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22PHARMACOGENOMICS%22">PHARMACOGENOMICS</searchLink><br /><searchLink fieldCode="DE" term="%22FLUOROURACIL%22">FLUOROURACIL</searchLink><br /><searchLink fieldCode="DE" term="%22GENOTYPES%22">GENOTYPES</searchLink><br /><searchLink fieldCode="DE" term="%22SINGLE+nucleotide+polymorphisms%22">SINGLE nucleotide polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22PATIENTS'+attitudes%22">PATIENTS' attitudes</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The article focuses on clarifying misunderstandings and responding to critiques of a previous editorial regarding DPYD genotyping and fluoropyrimidine-related toxicities. Topics include the complexity and limitations of current DPYD testing, the rare occurrence of absolute DPYD deficiency, and the importance of patient and clinician choice in testing decisions.
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1200/OP-24-00923
    Languages:
      – Code: eng
        Text: English
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      Pagination:
        PageCount: 2
        StartPage: 265
    Subjects:
      – SubjectFull: INBORN errors of metabolism
        Type: general
      – SubjectFull: CANCER chemotherapy
        Type: general
      – SubjectFull: PHARMACOGENOMICS
        Type: general
      – SubjectFull: FLUOROURACIL
        Type: general
      – SubjectFull: GENOTYPES
        Type: general
      – SubjectFull: SINGLE nucleotide polymorphisms
        Type: general
      – SubjectFull: PATIENTS' attitudes
        Type: general
    Titles:
      – TitleFull: Reply to: "Give Patients the Choice to Test for DPD Deficiency Before Fluoropyrimidine Chemotherapy," "Large-Scale DPD Testing Should Be More Than an Option," and "A Big Problem With a Feasible Solution, Not a Small Problem With a Complex Solution".
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      – PersonEntity:
          Name:
            NameFull: Tamraz, Bani
      – PersonEntity:
          Name:
            NameFull: Venook, Alan P.
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          Dates:
            – D: 01
              M: 02
              Text: Feb2025
              Type: published
              Y: 2025
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              Value: 21
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              Value: 2
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            – TitleFull: JCO Oncology Practice
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