Pharmacological treatment in Idiopathic Pulmonary Fibrosis: current issues and future perspectives.
| Title: | Pharmacological treatment in Idiopathic Pulmonary Fibrosis: current issues and future perspectives. |
|---|---|
| Authors: | Sciacca, Enrico, Muscato, Giuseppe, Spicuzza, Lucia, Fruciano, Mary, Gili, Elisa, Sambataro, Gianluca, Palmucci, Stefano, Vancheri, Carlo, Libra, Alessandro |
| Source: | Multidisciplinary Respiratory Medicine; 2024, Vol. 19, p1-20, 20p |
| Subject Terms: | IDIOPATHIC pulmonary fibrosis, INTERSTITIAL lung diseases, DRUG therapy, DISEASE progression, PROGNOSIS |
| Abstract: | Idiopathic pulmonary fibrosis (IPF) represents a fibrotic interstitial lung disease characterized by uncertain etiology and poor prognosis. Over the years, the path to effective treatments has been marked by a series of advances and setbacks. The introduction of approved antifibrotic drugs, pirfenidone and nintedanib, marked a pivotal moment in the management of IPF. However, despite these advances, these drugs are not curative, although they can slow the natural progression of the disease. The history of drug therapy for IPF goes together with the increased understanding of the pathogenic mechanisms underlying the disease. Based on that, current research efforts continue to explore new therapies, possible personalized treatment strategies, drug combinations, and potential biomarkers for diagnosis and prognosis. In this review, we outline the route that led to the discover of the first effective therapies, ongoing clinical trials, and future directions in the search for more effective treatments. [ABSTRACT FROM AUTHOR] |
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| Database: | Complementary Index |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.5826/mrm.2024.982 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 20 StartPage: 1 Subjects: – SubjectFull: IDIOPATHIC pulmonary fibrosis Type: general – SubjectFull: INTERSTITIAL lung diseases Type: general – SubjectFull: DRUG therapy Type: general – SubjectFull: DISEASE progression Type: general – SubjectFull: PROGNOSIS Type: general Titles: – TitleFull: Pharmacological treatment in Idiopathic Pulmonary Fibrosis: current issues and future perspectives. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sciacca, Enrico – PersonEntity: Name: NameFull: Muscato, Giuseppe – PersonEntity: Name: NameFull: Spicuzza, Lucia – PersonEntity: Name: NameFull: Fruciano, Mary – PersonEntity: Name: NameFull: Gili, Elisa – PersonEntity: Name: NameFull: Sambataro, Gianluca – PersonEntity: Name: NameFull: Palmucci, Stefano – PersonEntity: Name: NameFull: Vancheri, Carlo – PersonEntity: Name: NameFull: Libra, Alessandro IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: 2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 1828695X Numbering: – Type: volume Value: 19 Titles: – TitleFull: Multidisciplinary Respiratory Medicine Type: main |
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