Behavioral variant frontotemporal dementia with pathogenic variant in MAPT presenting as dementia with Lewy body disease.
| Title: | Behavioral variant frontotemporal dementia with pathogenic variant in MAPT presenting as dementia with Lewy body disease. |
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| Authors: | Xia, Tianxu, Li, Clara, Iverson, Ayuko, Spat-Lemus, Jessica, Woroch, Amy, Naasan, Georges |
| Source: | Neurocase (Taylor & Francis Ltd); Feb2025, Vol. 31 Issue 1, p23-28, 6p |
| Subject Terms: | LEWY body dementia, FRONTOTEMPORAL dementia, CHINESE Americans, SYMPTOMS, CLINICAL neuropsychology |
| Abstract: | A 75-year-old Chinese American man presented to behavioral neurology clinic for a second opinion of dementia with Lewy body disease (DLB). The clinical manifestations met the criteria for a probable DLB diagnosis. Yet, in-depth evaluation unveiled clinical history, family history, and neuroimaging evidences that suggested a diagnosis of behavioral variant frontotemporal dementia (FTD). A heterozygous pathogenic variant in the microtubule-associated protein Tau (MAPT) was identified through genetic testing and confirmed the diagnosis of autosomal dominant MAPT-related FTD. This case is the first reported instance of MAPT-related FTD presenting with well-formed visual hallucinations in an elderly Chinese American. [ABSTRACT FROM AUTHOR] |
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| Database: | Complementary Index |
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