A 40-Year-Old With Prior Stem Cell Transplant for Chronic Myeloid Leukemia Presents With Dyspnea and Respiratory Failure.

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Title: A 40-Year-Old With Prior Stem Cell Transplant for Chronic Myeloid Leukemia Presents With Dyspnea and Respiratory Failure.
Authors: Naiditch, Hiam, Strollo, Hilary, Gipson, Vanessa, Sica, Gabriel, Joshi, Urvashi, Ito, Sawa, Rossetti, James, Hensley, Matthew
Source: CHEST; Feb2025, Vol. 167 Issue 2, pe47-e51, 5p
Subject Terms: CHRONIC myeloid leukemia, PULMONARY nodules, BRONCHOALVEOLAR lavage, HOSPITAL admission & discharge, RESPIRATORY insufficiency
Abstract: A 40-year-old man with chronic myeloid leukemia presented to the hospital with recurrent dyspnea and hypoxemic respiratory failure. He presented from his outpatient transplant infectious diseases appointment with dyspnea, cough, worsening hypoxemia, acute kidney injury, and somnolence after discharge from the hospital 2 weeks prior with a similar presentation. During the previous hospital stay, he underwent bronchoscopy and alveolar lavage with negative infectious workup. He was prescribed caspofungin, amphotericin, and continued posaconazole for prior probable invasive fungal infection (elevated blood BD-glucan and pulmonary nodules). Antibiotics included previous meropenem for esophageal nocardiosis, cefepime and azithromycin during admission, and now ceftriaxone for nocardiosis in the outpatient setting for convenience of home infusion. He was prescribed diuretics for presumed volume overload. Despite home diuretics, antimicrobials, and supplemental oxygen, he re-presented with worsening symptoms. [ABSTRACT FROM AUTHOR]
Copyright of CHEST is the property of American College of Chest Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: A 40-Year-Old With Prior Stem Cell Transplant for Chronic Myeloid Leukemia Presents With Dyspnea and Respiratory Failure.
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  Data: <searchLink fieldCode="AR" term="%22Naiditch%2C+Hiam%22">Naiditch, Hiam</searchLink><br /><searchLink fieldCode="AR" term="%22Strollo%2C+Hilary%22">Strollo, Hilary</searchLink><br /><searchLink fieldCode="AR" term="%22Gipson%2C+Vanessa%22">Gipson, Vanessa</searchLink><br /><searchLink fieldCode="AR" term="%22Sica%2C+Gabriel%22">Sica, Gabriel</searchLink><br /><searchLink fieldCode="AR" term="%22Joshi%2C+Urvashi%22">Joshi, Urvashi</searchLink><br /><searchLink fieldCode="AR" term="%22Ito%2C+Sawa%22">Ito, Sawa</searchLink><br /><searchLink fieldCode="AR" term="%22Rossetti%2C+James%22">Rossetti, James</searchLink><br /><searchLink fieldCode="AR" term="%22Hensley%2C+Matthew%22">Hensley, Matthew</searchLink>
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  Data: CHEST; Feb2025, Vol. 167 Issue 2, pe47-e51, 5p
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  Data: <searchLink fieldCode="DE" term="%22CHRONIC+myeloid+leukemia%22">CHRONIC myeloid leukemia</searchLink><br /><searchLink fieldCode="DE" term="%22PULMONARY+nodules%22">PULMONARY nodules</searchLink><br /><searchLink fieldCode="DE" term="%22BRONCHOALVEOLAR+lavage%22">BRONCHOALVEOLAR lavage</searchLink><br /><searchLink fieldCode="DE" term="%22HOSPITAL+admission+%26+discharge%22">HOSPITAL admission & discharge</searchLink><br /><searchLink fieldCode="DE" term="%22RESPIRATORY+insufficiency%22">RESPIRATORY insufficiency</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: A 40-year-old man with chronic myeloid leukemia presented to the hospital with recurrent dyspnea and hypoxemic respiratory failure. He presented from his outpatient transplant infectious diseases appointment with dyspnea, cough, worsening hypoxemia, acute kidney injury, and somnolence after discharge from the hospital 2 weeks prior with a similar presentation. During the previous hospital stay, he underwent bronchoscopy and alveolar lavage with negative infectious workup. He was prescribed caspofungin, amphotericin, and continued posaconazole for prior probable invasive fungal infection (elevated blood BD-glucan and pulmonary nodules). Antibiotics included previous meropenem for esophageal nocardiosis, cefepime and azithromycin during admission, and now ceftriaxone for nocardiosis in the outpatient setting for convenience of home infusion. He was prescribed diuretics for presumed volume overload. Despite home diuretics, antimicrobials, and supplemental oxygen, he re-presented with worsening symptoms. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of CHEST is the property of American College of Chest Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.chest.2024.08.011
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      – Code: eng
        Text: English
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        StartPage: e47
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      – SubjectFull: CHRONIC myeloid leukemia
        Type: general
      – SubjectFull: PULMONARY nodules
        Type: general
      – SubjectFull: BRONCHOALVEOLAR lavage
        Type: general
      – SubjectFull: HOSPITAL admission & discharge
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      – SubjectFull: RESPIRATORY insufficiency
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      – TitleFull: A 40-Year-Old With Prior Stem Cell Transplant for Chronic Myeloid Leukemia Presents With Dyspnea and Respiratory Failure.
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              Text: Feb2025
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              Y: 2025
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