Decoding the mechanisms behind second primary cancers.
| Title: | Decoding the mechanisms behind second primary cancers. |
|---|---|
| Authors: | Zeng, Meiyuan, Lin, Anqi, Jiang, Aimin, Qiu, Zhengang, Zhang, Hongman, Chen, Shifu, Xu, Mingyan, Liu, Zaoqu, Cheng, Quan, Zhang, Jian, Luo, Peng |
| Source: | Journal of Translational Medicine; 1/24/2025, Vol. 23 Issue 1, p1-18, 18p |
| Subject Terms: | CELL-free DNA, HORMONE receptors, GENE expression, CYTOLOGY, PHENOTYPIC plasticity |
| Abstract: | Second Primary Cancers (SPCs) are defined as cancers that develop either simultaneously or metachronously in the same individual who has been diagnosed with and survived one primary cancer. SPCs exhibit a high incidence rate and represent the primary cause of mortality among survivors of first primary cancers. There is growing concern about the dangers of SPCs. This review summarizes recent studies on the mechanisms of SPCs, including the roles of genomic changes after first primary cancer (FPC) treatments, stromal cell phenotypic and metabolic changes, hormone levels and receptor expression, immunosuppression, aberrant gene methylation, EGFR signaling, and cell-free DNA in SPC development. This comprehensive analysis contributes to elucidating current research trends in SPC mechanisms and enhances our understanding of the underlying pathophysiology. Furthermore, potential applications of intratumoral microbes, single-cell multi-omics, and metabolomics in investigating SPC mechanisms are also discussed, providing new ideas for follow-up studies. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Translational Medicine is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Complementary Index |
| Full text is not displayed to guests. | Login for full access. |
Be the first to leave a comment!