Academic Journal
View in EDS
HTML Full Text

Decoding the mechanisms behind second primary cancers.

Bibliographic Details
Title: Decoding the mechanisms behind second primary cancers.
Authors: Zeng, Meiyuan, Lin, Anqi, Jiang, Aimin, Qiu, Zhengang, Zhang, Hongman, Chen, Shifu, Xu, Mingyan, Liu, Zaoqu, Cheng, Quan, Zhang, Jian, Luo, Peng
Source: Journal of Translational Medicine; 1/24/2025, Vol. 23 Issue 1, p1-18, 18p
Subject Terms: CELL-free DNA, HORMONE receptors, GENE expression, CYTOLOGY, PHENOTYPIC plasticity
Abstract: Second Primary Cancers (SPCs) are defined as cancers that develop either simultaneously or metachronously in the same individual who has been diagnosed with and survived one primary cancer. SPCs exhibit a high incidence rate and represent the primary cause of mortality among survivors of first primary cancers. There is growing concern about the dangers of SPCs. This review summarizes recent studies on the mechanisms of SPCs, including the roles of genomic changes after first primary cancer (FPC) treatments, stromal cell phenotypic and metabolic changes, hormone levels and receptor expression, immunosuppression, aberrant gene methylation, EGFR signaling, and cell-free DNA in SPC development. This comprehensive analysis contributes to elucidating current research trends in SPC mechanisms and enhances our understanding of the underlying pathophysiology. Furthermore, potential applications of intratumoral microbes, single-cell multi-omics, and metabolomics in investigating SPC mechanisms are also discussed, providing new ideas for follow-up studies. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Translational Medicine is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Complementary Index
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
CustomLinks:
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edb&genre=article&issn=14795876&ISBN=&volume=23&issue=1&date=20250124&spage=1&pages=1-18&title=Journal of Translational Medicine&atitle=Decoding%20the%20mechanisms%20behind%20second%20primary%20cancers.&aulast=Zeng%2C%20Meiyuan&id=DOI:10.1186/s12967-025-06151-9
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
Header DbId: edb
DbLabel: Complementary Index
An: 182466636
RelevancyScore: 1082
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 1082.12048339844
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Decoding the mechanisms behind second primary cancers.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Zeng%2C+Meiyuan%22">Zeng, Meiyuan</searchLink><br /><searchLink fieldCode="AR" term="%22Lin%2C+Anqi%22">Lin, Anqi</searchLink><br /><searchLink fieldCode="AR" term="%22Jiang%2C+Aimin%22">Jiang, Aimin</searchLink><br /><searchLink fieldCode="AR" term="%22Qiu%2C+Zhengang%22">Qiu, Zhengang</searchLink><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Hongman%22">Zhang, Hongman</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+Shifu%22">Chen, Shifu</searchLink><br /><searchLink fieldCode="AR" term="%22Xu%2C+Mingyan%22">Xu, Mingyan</searchLink><br /><searchLink fieldCode="AR" term="%22Liu%2C+Zaoqu%22">Liu, Zaoqu</searchLink><br /><searchLink fieldCode="AR" term="%22Cheng%2C+Quan%22">Cheng, Quan</searchLink><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Jian%22">Zhang, Jian</searchLink><br /><searchLink fieldCode="AR" term="%22Luo%2C+Peng%22">Luo, Peng</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: Journal of Translational Medicine; 1/24/2025, Vol. 23 Issue 1, p1-18, 18p
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22CELL-free+DNA%22">CELL-free DNA</searchLink><br /><searchLink fieldCode="DE" term="%22HORMONE+receptors%22">HORMONE receptors</searchLink><br /><searchLink fieldCode="DE" term="%22GENE+expression%22">GENE expression</searchLink><br /><searchLink fieldCode="DE" term="%22CYTOLOGY%22">CYTOLOGY</searchLink><br /><searchLink fieldCode="DE" term="%22PHENOTYPIC+plasticity%22">PHENOTYPIC plasticity</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Second Primary Cancers (SPCs) are defined as cancers that develop either simultaneously or metachronously in the same individual who has been diagnosed with and survived one primary cancer. SPCs exhibit a high incidence rate and represent the primary cause of mortality among survivors of first primary cancers. There is growing concern about the dangers of SPCs. This review summarizes recent studies on the mechanisms of SPCs, including the roles of genomic changes after first primary cancer (FPC) treatments, stromal cell phenotypic and metabolic changes, hormone levels and receptor expression, immunosuppression, aberrant gene methylation, EGFR signaling, and cell-free DNA in SPC development. This comprehensive analysis contributes to elucidating current research trends in SPC mechanisms and enhances our understanding of the underlying pathophysiology. Furthermore, potential applications of intratumoral microbes, single-cell multi-omics, and metabolomics in investigating SPC mechanisms are also discussed, providing new ideas for follow-up studies. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Translational Medicine is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edb&AN=182466636
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1186/s12967-025-06151-9
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 18
        StartPage: 1
    Subjects:
      – SubjectFull: CELL-free DNA
        Type: general
      – SubjectFull: HORMONE receptors
        Type: general
      – SubjectFull: GENE expression
        Type: general
      – SubjectFull: CYTOLOGY
        Type: general
      – SubjectFull: PHENOTYPIC plasticity
        Type: general
    Titles:
      – TitleFull: Decoding the mechanisms behind second primary cancers.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Zeng, Meiyuan
      – PersonEntity:
          Name:
            NameFull: Lin, Anqi
      – PersonEntity:
          Name:
            NameFull: Jiang, Aimin
      – PersonEntity:
          Name:
            NameFull: Qiu, Zhengang
      – PersonEntity:
          Name:
            NameFull: Zhang, Hongman
      – PersonEntity:
          Name:
            NameFull: Chen, Shifu
      – PersonEntity:
          Name:
            NameFull: Xu, Mingyan
      – PersonEntity:
          Name:
            NameFull: Liu, Zaoqu
      – PersonEntity:
          Name:
            NameFull: Cheng, Quan
      – PersonEntity:
          Name:
            NameFull: Zhang, Jian
      – PersonEntity:
          Name:
            NameFull: Luo, Peng
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 24
              M: 01
              Text: 1/24/2025
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-print
              Value: 14795876
          Numbering:
            – Type: volume
              Value: 23
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Journal of Translational Medicine
              Type: main
ResultId 1