Five New Indole Alkaloid Derivatives from Deep-Sea Fungus Aspergillus fumigatus AF1.
| Title: | Five New Indole Alkaloid Derivatives from Deep-Sea Fungus Aspergillus fumigatus AF1. |
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| Authors: | Dai, Lai-Hui, Zhang, Gao-Rong, Ou, Yang-Hui, Liu, Xiao-Jing, Yao, Hong-Liang, Hu, Wen-Hao, Li, Hou-Jin, Lan, Wen-Jian |
| Source: | Marine Drugs; Jan2025, Vol. 23 Issue 1, p4, 16p |
| Abstract: | One new gliotoxin derivative fumianthrogliotoxin (1), one new indoquizoline alkaloid N3-(methyl propionate) indoquizoline (2), and three novel indole alkaloids, anthroxyindole (3), (±)-asperfumiindole A (4), and (±)-asperfumiindole B (5), together with 16 known compounds (6–21), were isolated from the culture of deep-sea derived fungus Aspergillus fumigatus AF1. Their chemical structures and absolute configurations were determined through the analysis of NMR data in combination with electronic circular dichroism (ECD) calculations and other spectroscopic analyses. Compounds 2–11 and 13–21 were evaluated for anti-pulmonary fibrosis activity. Compounds 8 and 13 displayed significant downregulation of the mRNA expression levels of all three molecular markers (COL1A1, α-SMA and FN1), with compound 13 exhibiting the best performance among all the tested compounds. [ABSTRACT FROM AUTHOR] |
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| Database: | Complementary Index |
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| Items | – Name: Title Label: Title Group: Ti Data: Five New Indole Alkaloid Derivatives from Deep-Sea Fungus Aspergillus fumigatus AF1. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Dai%2C+Lai-Hui%22">Dai, Lai-Hui</searchLink><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Gao-Rong%22">Zhang, Gao-Rong</searchLink><br /><searchLink fieldCode="AR" term="%22Ou%2C+Yang-Hui%22">Ou, Yang-Hui</searchLink><br /><searchLink fieldCode="AR" term="%22Liu%2C+Xiao-Jing%22">Liu, Xiao-Jing</searchLink><br /><searchLink fieldCode="AR" term="%22Yao%2C+Hong-Liang%22">Yao, Hong-Liang</searchLink><br /><searchLink fieldCode="AR" term="%22Hu%2C+Wen-Hao%22">Hu, Wen-Hao</searchLink><br /><searchLink fieldCode="AR" term="%22Li%2C+Hou-Jin%22">Li, Hou-Jin</searchLink><br /><searchLink fieldCode="AR" term="%22Lan%2C+Wen-Jian%22">Lan, Wen-Jian</searchLink> – Name: TitleSource Label: Source Group: Src Data: Marine Drugs; Jan2025, Vol. 23 Issue 1, p4, 16p – Name: Abstract Label: Abstract Group: Ab Data: One new gliotoxin derivative fumianthrogliotoxin (1), one new indoquizoline alkaloid N3-(methyl propionate) indoquizoline (2), and three novel indole alkaloids, anthroxyindole (3), (±)-asperfumiindole A (4), and (±)-asperfumiindole B (5), together with 16 known compounds (6–21), were isolated from the culture of deep-sea derived fungus Aspergillus fumigatus AF1. Their chemical structures and absolute configurations were determined through the analysis of NMR data in combination with electronic circular dichroism (ECD) calculations and other spectroscopic analyses. Compounds 2–11 and 13–21 were evaluated for anti-pulmonary fibrosis activity. Compounds 8 and 13 displayed significant downregulation of the mRNA expression levels of all three molecular markers (COL1A1, α-SMA and FN1), with compound 13 exhibiting the best performance among all the tested compounds. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Marine Drugs is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/md23010004 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 16 StartPage: 4 Titles: – TitleFull: Five New Indole Alkaloid Derivatives from Deep-Sea Fungus Aspergillus fumigatus AF1. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Dai, Lai-Hui – PersonEntity: Name: NameFull: Zhang, Gao-Rong – PersonEntity: Name: NameFull: Ou, Yang-Hui – PersonEntity: Name: NameFull: Liu, Xiao-Jing – PersonEntity: Name: NameFull: Yao, Hong-Liang – PersonEntity: Name: NameFull: Hu, Wen-Hao – PersonEntity: Name: NameFull: Li, Hou-Jin – PersonEntity: Name: NameFull: Lan, Wen-Jian IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 16603397 Numbering: – Type: volume Value: 23 – Type: issue Value: 1 Titles: – TitleFull: Marine Drugs Type: main |
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