Sustained Depolarization Induces Gene Expression Pattern Changes Related to Synaptic Plasticity in a Human Cholinergic Cellular Model.
| Title: | Sustained Depolarization Induces Gene Expression Pattern Changes Related to Synaptic Plasticity in a Human Cholinergic Cellular Model. |
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| Authors: | Carrese, Anna Maria, Vitale, Rossella, Turco, Manuela, Masola, Valeria, Aniello, Francesco, Vitale, Emilia, Donizetti, Aldo |
| Source: | Molecular Neurobiology; Jan2025, Vol. 62 Issue 1, p935-945, 11p |
| Abstract: | Neuronal gene expression in the brain dynamically responds to synaptic activity. The interplay among synaptic activity, gene expression, and synaptic plasticity has crucial implications for understanding the pathophysiology of diseases such as Alzheimer's disease and epilepsy. These diseases are marked by synaptic dysfunction that affects the expression patterns of neuroprotective genes that are incompletely understood. In our study, we developed a cellular model of synaptic activity using human cholinergic neurons derived from SH-SY5Y cell differentiation. Depolarization induction modulates the expression of neurotrophic genes and synaptic markers, indicating a potential role in synaptic plasticity regulation. This hypothesis is further supported by the induction kinetics of various long non-coding RNAs, including primate-specific ones. Our experimental model showcases the utility of SH-SY5Y cells in elucidating the molecular mechanisms underlying synaptic plasticity in human cellular systems. [ABSTRACT FROM AUTHOR] |
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| Database: | Complementary Index |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s12035-024-04262-w Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 935 Titles: – TitleFull: Sustained Depolarization Induces Gene Expression Pattern Changes Related to Synaptic Plasticity in a Human Cholinergic Cellular Model. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Carrese, Anna Maria – PersonEntity: Name: NameFull: Vitale, Rossella – PersonEntity: Name: NameFull: Turco, Manuela – PersonEntity: Name: NameFull: Masola, Valeria – PersonEntity: Name: NameFull: Aniello, Francesco – PersonEntity: Name: NameFull: Vitale, Emilia – PersonEntity: Name: NameFull: Donizetti, Aldo IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 08937648 Numbering: – Type: volume Value: 62 – Type: issue Value: 1 Titles: – TitleFull: Molecular Neurobiology Type: main |
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