Hippocampal volumes in UK Biobank are associated with APOE only in older adults.
| Title: | Hippocampal volumes in UK Biobank are associated with APOE only in older adults. |
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| Authors: | Chaloemtoem, Ariya, Thornton, Vera, Chang, Yoonhoo, Anokhin, Andrey P., Belloy, Michaël E., Bijsterbosch, Janine, Gordon, Brian A., Hartz, Sarah M., Bierut, Laura J. |
| Source: | Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring; Oct2024, Vol. 16 Issue 4, p1-9, 9p |
| Subject Terms: | APOLIPOPROTEIN E, ALZHEIMER'S disease, OLDER people, NEURODEGENERATION, HIPPOCAMPUS (Brain) |
| Abstract: | INTRODUCTION: The hippocampus atrophies with age and is implicated in neurodegenerative disorders including Alzheimer's disease (AD). We examined the interplay between age and apolipoprotein E (APOE) genotype on total hippocampal volume. METHODS: Using neuroimaging data from 37,463 UK Biobank participants, we applied linear regression to quantify the association of age and APOE with hippocampal volume and identified the age when volumes of ε2/ε3, ε3/ε4, and ε4/ε4 carriers significantly deviated from ε3/ε3 using generalized additive modeling. RESULTS: Total hippocampal volume declined with age, with significant differences by APOE genotype emerging after age 60. ε3/ε4 and ε4/ε4 carriers displayed reduced volumes from ages 69 and 61, respectively, while ε2/ε3 showed delayed decline starting at the age of 76. DISCUSSION: The association of APOE and hippocampal volume is age‐dependent, with differences in volumes of ε4/ε4 carriers detected as early as age 61. This work underscores the importance of APOE genotype in determining when to begin screening for AD. Highlights: Apolipoprotein E (APOE) genotype shows an age‐dependent association with total hippocampal volume.No association between APOE and total hippocampal volume was detected before age 60.Accelerated decline was observed in ε4/ε4 carriers at age 61 and ε3/ε4 at age 69.Delayed decline was evident in ε2/ε3 carriers starting at age 76. [ABSTRACT FROM AUTHOR] |
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| Database: | Complementary Index |
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| Items | – Name: Title Label: Title Group: Ti Data: Hippocampal volumes in UK Biobank are associated with APOE only in older adults. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Chaloemtoem%2C+Ariya%22">Chaloemtoem, Ariya</searchLink><br /><searchLink fieldCode="AR" term="%22Thornton%2C+Vera%22">Thornton, Vera</searchLink><br /><searchLink fieldCode="AR" term="%22Chang%2C+Yoonhoo%22">Chang, Yoonhoo</searchLink><br /><searchLink fieldCode="AR" term="%22Anokhin%2C+Andrey+P%2E%22">Anokhin, Andrey P.</searchLink><br /><searchLink fieldCode="AR" term="%22Belloy%2C+Michaël+E%2E%22">Belloy, Michaël E.</searchLink><br /><searchLink fieldCode="AR" term="%22Bijsterbosch%2C+Janine%22">Bijsterbosch, Janine</searchLink><br /><searchLink fieldCode="AR" term="%22Gordon%2C+Brian+A%2E%22">Gordon, Brian A.</searchLink><br /><searchLink fieldCode="AR" term="%22Hartz%2C+Sarah+M%2E%22">Hartz, Sarah M.</searchLink><br /><searchLink fieldCode="AR" term="%22Bierut%2C+Laura+J%2E%22">Bierut, Laura J.</searchLink> – Name: TitleSource Label: Source Group: Src Data: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring; Oct2024, Vol. 16 Issue 4, p1-9, 9p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22APOLIPOPROTEIN+E%22">APOLIPOPROTEIN E</searchLink><br /><searchLink fieldCode="DE" term="%22ALZHEIMER'S+disease%22">ALZHEIMER'S disease</searchLink><br /><searchLink fieldCode="DE" term="%22OLDER+people%22">OLDER people</searchLink><br /><searchLink fieldCode="DE" term="%22NEURODEGENERATION%22">NEURODEGENERATION</searchLink><br /><searchLink fieldCode="DE" term="%22HIPPOCAMPUS+%28Brain%29%22">HIPPOCAMPUS (Brain)</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: INTRODUCTION: The hippocampus atrophies with age and is implicated in neurodegenerative disorders including Alzheimer's disease (AD). We examined the interplay between age and apolipoprotein E (APOE) genotype on total hippocampal volume. METHODS: Using neuroimaging data from 37,463 UK Biobank participants, we applied linear regression to quantify the association of age and APOE with hippocampal volume and identified the age when volumes of ε2/ε3, ε3/ε4, and ε4/ε4 carriers significantly deviated from ε3/ε3 using generalized additive modeling. RESULTS: Total hippocampal volume declined with age, with significant differences by APOE genotype emerging after age 60. ε3/ε4 and ε4/ε4 carriers displayed reduced volumes from ages 69 and 61, respectively, while ε2/ε3 showed delayed decline starting at the age of 76. DISCUSSION: The association of APOE and hippocampal volume is age‐dependent, with differences in volumes of ε4/ε4 carriers detected as early as age 61. This work underscores the importance of APOE genotype in determining when to begin screening for AD. Highlights: Apolipoprotein E (APOE) genotype shows an age‐dependent association with total hippocampal volume.No association between APOE and total hippocampal volume was detected before age 60.Accelerated decline was observed in ε4/ε4 carriers at age 61 and ε3/ε4 at age 69.Delayed decline was evident in ε2/ε3 carriers starting at age 76. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/dad2.70024 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 1 Subjects: – SubjectFull: APOLIPOPROTEIN E Type: general – SubjectFull: ALZHEIMER'S disease Type: general – SubjectFull: OLDER people Type: general – SubjectFull: NEURODEGENERATION Type: general – SubjectFull: HIPPOCAMPUS (Brain) Type: general Titles: – TitleFull: Hippocampal volumes in UK Biobank are associated with APOE only in older adults. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Chaloemtoem, Ariya – PersonEntity: Name: NameFull: Thornton, Vera – PersonEntity: Name: NameFull: Chang, Yoonhoo – PersonEntity: Name: NameFull: Anokhin, Andrey P. – PersonEntity: Name: NameFull: Belloy, Michaël E. – PersonEntity: Name: NameFull: Bijsterbosch, Janine – PersonEntity: Name: NameFull: Gordon, Brian A. – PersonEntity: Name: NameFull: Hartz, Sarah M. – PersonEntity: Name: NameFull: Bierut, Laura J. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 23528729 Numbering: – Type: volume Value: 16 – Type: issue Value: 4 Titles: – TitleFull: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring Type: main |
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