AURORA: A New Dawn.
| Title: | AURORA: A New Dawn. |
|---|---|
| Authors: | Papanicolaou, Genovefa A, Avery, Robin K, Cordonnier, Catherine, Duarte, Rafael F, Haider, Shariq, Maertens, Johan, Peggs, Karl S, Solano, Carlos, Young, Jo-Anne H, Fournier, Martha, Murray, Rose Ann, Wu, Jingyang, Bo, Tien, Winston, Drew J |
| Source: | Clinical Infectious Diseases; 12/15/2024, Vol. 79 Issue 6, p1535-1537, 3p |
| Subject Terms: | HEMATOPOIETIC stem cell transplantation, PROTEIN kinase inhibitors, PATIENT safety, CYTOMEGALOVIRUS diseases, TERMINATION of treatment, CELLULAR immunity, SURGICAL complications, ANTIVIRAL agents, REINFECTION, VALGANCICLOVIR, DRUG efficacy, VIREMIA, GRANULOCYTE-colony stimulating factor, DRUG resistance, NEUTROPENIA |
| Abstract: | The article discusses the AURORA trial, the first randomized, double-blind study comparing two oral antiviral agents for cytomegalovirus (CMV) clearance. Topics include the limitations of the 8-week treatment period, which was longer than the typical clinical practice of stopping treatment upon viral clearance; the dose interruption or reduction of valganciclovir in patients with grade 3 neutropenia; and the concern regarding treatment-emergent resistance observed during the trial. |
| Database: | Complementary Index |
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| Header | DbId: edb DbLabel: Complementary Index An: 181734644 RelevancyScore: 1033 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 1032.71325683594 |
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| Items | – Name: Title Label: Title Group: Ti Data: AURORA: A New Dawn. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Papanicolaou%2C+Genovefa+A%22">Papanicolaou, Genovefa A</searchLink><br /><searchLink fieldCode="AR" term="%22Avery%2C+Robin+K%22">Avery, Robin K</searchLink><br /><searchLink fieldCode="AR" term="%22Cordonnier%2C+Catherine%22">Cordonnier, Catherine</searchLink><br /><searchLink fieldCode="AR" term="%22Duarte%2C+Rafael+F%22">Duarte, Rafael F</searchLink><br /><searchLink fieldCode="AR" term="%22Haider%2C+Shariq%22">Haider, Shariq</searchLink><br /><searchLink fieldCode="AR" term="%22Maertens%2C+Johan%22">Maertens, Johan</searchLink><br /><searchLink fieldCode="AR" term="%22Peggs%2C+Karl+S%22">Peggs, Karl S</searchLink><br /><searchLink fieldCode="AR" term="%22Solano%2C+Carlos%22">Solano, Carlos</searchLink><br /><searchLink fieldCode="AR" term="%22Young%2C+Jo-Anne+H%22">Young, Jo-Anne H</searchLink><br /><searchLink fieldCode="AR" term="%22Fournier%2C+Martha%22">Fournier, Martha</searchLink><br /><searchLink fieldCode="AR" term="%22Murray%2C+Rose+Ann%22">Murray, Rose Ann</searchLink><br /><searchLink fieldCode="AR" term="%22Wu%2C+Jingyang%22">Wu, Jingyang</searchLink><br /><searchLink fieldCode="AR" term="%22Bo%2C+Tien%22">Bo, Tien</searchLink><br /><searchLink fieldCode="AR" term="%22Winston%2C+Drew+J%22">Winston, Drew J</searchLink> – Name: TitleSource Label: Source Group: Src Data: Clinical Infectious Diseases; 12/15/2024, Vol. 79 Issue 6, p1535-1537, 3p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22HEMATOPOIETIC+stem+cell+transplantation%22">HEMATOPOIETIC stem cell transplantation</searchLink><br /><searchLink fieldCode="DE" term="%22PROTEIN+kinase+inhibitors%22">PROTEIN kinase inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22PATIENT+safety%22">PATIENT safety</searchLink><br /><searchLink fieldCode="DE" term="%22CYTOMEGALOVIRUS+diseases%22">CYTOMEGALOVIRUS diseases</searchLink><br /><searchLink fieldCode="DE" term="%22TERMINATION+of+treatment%22">TERMINATION of treatment</searchLink><br /><searchLink fieldCode="DE" term="%22CELLULAR+immunity%22">CELLULAR immunity</searchLink><br /><searchLink fieldCode="DE" term="%22SURGICAL+complications%22">SURGICAL complications</searchLink><br /><searchLink fieldCode="DE" term="%22ANTIVIRAL+agents%22">ANTIVIRAL agents</searchLink><br /><searchLink fieldCode="DE" term="%22REINFECTION%22">REINFECTION</searchLink><br /><searchLink fieldCode="DE" term="%22VALGANCICLOVIR%22">VALGANCICLOVIR</searchLink><br /><searchLink fieldCode="DE" term="%22DRUG+efficacy%22">DRUG efficacy</searchLink><br /><searchLink fieldCode="DE" term="%22VIREMIA%22">VIREMIA</searchLink><br /><searchLink fieldCode="DE" term="%22GRANULOCYTE-colony+stimulating+factor%22">GRANULOCYTE-colony stimulating factor</searchLink><br /><searchLink fieldCode="DE" term="%22DRUG+resistance%22">DRUG resistance</searchLink><br /><searchLink fieldCode="DE" term="%22NEUTROPENIA%22">NEUTROPENIA</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The article discusses the AURORA trial, the first randomized, double-blind study comparing two oral antiviral agents for cytomegalovirus (CMV) clearance. Topics include the limitations of the 8-week treatment period, which was longer than the typical clinical practice of stopping treatment upon viral clearance; the dose interruption or reduction of valganciclovir in patients with grade 3 neutropenia; and the concern regarding treatment-emergent resistance observed during the trial. |
| PLink | https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edb&AN=181734644 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1093/cid/ciae114 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 3 StartPage: 1535 Subjects: – SubjectFull: HEMATOPOIETIC stem cell transplantation Type: general – SubjectFull: PROTEIN kinase inhibitors Type: general – SubjectFull: PATIENT safety Type: general – SubjectFull: CYTOMEGALOVIRUS diseases Type: general – SubjectFull: TERMINATION of treatment Type: general – SubjectFull: CELLULAR immunity Type: general – SubjectFull: SURGICAL complications Type: general – SubjectFull: ANTIVIRAL agents Type: general – SubjectFull: REINFECTION Type: general – SubjectFull: VALGANCICLOVIR Type: general – SubjectFull: DRUG efficacy Type: general – SubjectFull: VIREMIA Type: general – SubjectFull: GRANULOCYTE-colony stimulating factor Type: general – SubjectFull: DRUG resistance Type: general – SubjectFull: NEUTROPENIA Type: general Titles: – TitleFull: AURORA: A New Dawn. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Papanicolaou, Genovefa A – PersonEntity: Name: NameFull: Avery, Robin K – PersonEntity: Name: NameFull: Cordonnier, Catherine – PersonEntity: Name: NameFull: Duarte, Rafael F – PersonEntity: Name: NameFull: Haider, Shariq – PersonEntity: Name: NameFull: Maertens, Johan – PersonEntity: Name: NameFull: Peggs, Karl S – PersonEntity: Name: NameFull: Solano, Carlos – PersonEntity: Name: NameFull: Young, Jo-Anne H – PersonEntity: Name: NameFull: Fournier, Martha – PersonEntity: Name: NameFull: Murray, Rose Ann – PersonEntity: Name: NameFull: Wu, Jingyang – PersonEntity: Name: NameFull: Bo, Tien – PersonEntity: Name: NameFull: Winston, Drew J IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 12 Text: 12/15/2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 10584838 Numbering: – Type: volume Value: 79 – Type: issue Value: 6 Titles: – TitleFull: Clinical Infectious Diseases Type: main |
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