Analysis of coinfections in patients with hematologic malignancies and COVID-19 by next-generation sequencing of bronchoalveolar lavage fluid.
| Title: | Analysis of coinfections in patients with hematologic malignancies and COVID-19 by next-generation sequencing of bronchoalveolar lavage fluid. |
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| Authors: | Shu, Wenxiu, Yang, Qianqian, Le, Jing, Cai, Qianqian, Dai, Hui, Luo, Liufei, Tong, Jiaqi, Song, Yanping, Chen, Bingrong, Tang, Yaodong, Jin, Dian |
| Source: | European Journal of Medical Research; 12/3/2024, Vol. 29 Issue 1, p1-9, 9p |
| Subject Terms: | COVID-19, MIXED infections, PNEUMOCYSTIS jiroveci, NUCLEOTIDE sequencing, HEMATOLOGIC malignancies |
| Abstract: | Background: Coinfections in patients with coronavirus disease 2019 (COVID-19) affect patient prognosis. Patients with hematologic malignancies (HMs) are usually immunosuppressed and may be at high risk of coinfection, but few related data have been reported. Here, we conducted a retrospective study to explore coinfections in patients with HMs and COVID-19 by next-generation sequencing (NGS) of bronchoalveolar lavage fluid (BALF). Methods: The data of hospitalized patients with pneumonia who underwent NGS analysis of BALF were reviewed. COVID-19 patients with HMs were enrolled in the HM group, and those without HMs were enrolled in the non-HM group. The coinfections of the two groups identified by NGS were analyzed. Results: Fifteen patients were enrolled in the HM group, and 14 patients were enrolled in the non-HM group. The coinfection rates in the HM group and non-HM group were 80.0% and 85.7%, respectively. The percentage of coinfected bacteria in the HM group was significantly lower than that in the non-HM group (20.0% vs 71.4%, p = 0.005). The coinfection rates of fungi and viruses were 60.0% and 35.7%, respectively, in the HM group and 35.7% and 78.6%, respectively, in the non-HM group, with no significant differences. The most common coexisting pathogen in patients with HMs was Pneumocystis jirovecii (33.3%), and the most common coexisting pathogen in patients without HMs was human gammaherpesvirus 4 (50%). Coinfection with herpesviruses occurred frequently in both groups. Conclusions: Our study showed that the majority of hospitalized patients with COVID-19 are likely to be co-infected with other pathogens. Pneumocystis jiroveci and herpesvirus are commonly coinfected pathogens in patients with HMs. Bacterial coinfection is rare in patients with HMs but is more common in patients without HMs. [ABSTRACT FROM AUTHOR] |
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| Items | – Name: Title Label: Title Group: Ti Data: Analysis of coinfections in patients with hematologic malignancies and COVID-19 by next-generation sequencing of bronchoalveolar lavage fluid. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Shu%2C+Wenxiu%22">Shu, Wenxiu</searchLink><br /><searchLink fieldCode="AR" term="%22Yang%2C+Qianqian%22">Yang, Qianqian</searchLink><br /><searchLink fieldCode="AR" term="%22Le%2C+Jing%22">Le, Jing</searchLink><br /><searchLink fieldCode="AR" term="%22Cai%2C+Qianqian%22">Cai, Qianqian</searchLink><br /><searchLink fieldCode="AR" term="%22Dai%2C+Hui%22">Dai, Hui</searchLink><br /><searchLink fieldCode="AR" term="%22Luo%2C+Liufei%22">Luo, Liufei</searchLink><br /><searchLink fieldCode="AR" term="%22Tong%2C+Jiaqi%22">Tong, Jiaqi</searchLink><br /><searchLink fieldCode="AR" term="%22Song%2C+Yanping%22">Song, Yanping</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+Bingrong%22">Chen, Bingrong</searchLink><br /><searchLink fieldCode="AR" term="%22Tang%2C+Yaodong%22">Tang, Yaodong</searchLink><br /><searchLink fieldCode="AR" term="%22Jin%2C+Dian%22">Jin, Dian</searchLink> – Name: TitleSource Label: Source Group: Src Data: European Journal of Medical Research; 12/3/2024, Vol. 29 Issue 1, p1-9, 9p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22COVID-19%22">COVID-19</searchLink><br /><searchLink fieldCode="DE" term="%22MIXED+infections%22">MIXED infections</searchLink><br /><searchLink fieldCode="DE" term="%22PNEUMOCYSTIS+jiroveci%22">PNEUMOCYSTIS jiroveci</searchLink><br /><searchLink fieldCode="DE" term="%22NUCLEOTIDE+sequencing%22">NUCLEOTIDE sequencing</searchLink><br /><searchLink fieldCode="DE" term="%22HEMATOLOGIC+malignancies%22">HEMATOLOGIC malignancies</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: Coinfections in patients with coronavirus disease 2019 (COVID-19) affect patient prognosis. Patients with hematologic malignancies (HMs) are usually immunosuppressed and may be at high risk of coinfection, but few related data have been reported. Here, we conducted a retrospective study to explore coinfections in patients with HMs and COVID-19 by next-generation sequencing (NGS) of bronchoalveolar lavage fluid (BALF). Methods: The data of hospitalized patients with pneumonia who underwent NGS analysis of BALF were reviewed. COVID-19 patients with HMs were enrolled in the HM group, and those without HMs were enrolled in the non-HM group. The coinfections of the two groups identified by NGS were analyzed. Results: Fifteen patients were enrolled in the HM group, and 14 patients were enrolled in the non-HM group. The coinfection rates in the HM group and non-HM group were 80.0% and 85.7%, respectively. The percentage of coinfected bacteria in the HM group was significantly lower than that in the non-HM group (20.0% vs 71.4%, p = 0.005). The coinfection rates of fungi and viruses were 60.0% and 35.7%, respectively, in the HM group and 35.7% and 78.6%, respectively, in the non-HM group, with no significant differences. The most common coexisting pathogen in patients with HMs was Pneumocystis jirovecii (33.3%), and the most common coexisting pathogen in patients without HMs was human gammaherpesvirus 4 (50%). Coinfection with herpesviruses occurred frequently in both groups. Conclusions: Our study showed that the majority of hospitalized patients with COVID-19 are likely to be co-infected with other pathogens. Pneumocystis jiroveci and herpesvirus are commonly coinfected pathogens in patients with HMs. Bacterial coinfection is rare in patients with HMs but is more common in patients without HMs. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of European Journal of Medical Research is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/s40001-024-02180-0 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 1 Subjects: – SubjectFull: COVID-19 Type: general – SubjectFull: MIXED infections Type: general – SubjectFull: PNEUMOCYSTIS jiroveci Type: general – SubjectFull: NUCLEOTIDE sequencing Type: general – SubjectFull: HEMATOLOGIC malignancies Type: general Titles: – TitleFull: Analysis of coinfections in patients with hematologic malignancies and COVID-19 by next-generation sequencing of bronchoalveolar lavage fluid. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Shu, Wenxiu – PersonEntity: Name: NameFull: Yang, Qianqian – PersonEntity: Name: NameFull: Le, Jing – PersonEntity: Name: NameFull: Cai, Qianqian – PersonEntity: Name: NameFull: Dai, Hui – PersonEntity: Name: NameFull: Luo, Liufei – PersonEntity: Name: NameFull: Tong, Jiaqi – PersonEntity: Name: NameFull: Song, Yanping – PersonEntity: Name: NameFull: Chen, Bingrong – PersonEntity: Name: NameFull: Tang, Yaodong – PersonEntity: Name: NameFull: Jin, Dian IsPartOfRelationships: – BibEntity: Dates: – D: 03 M: 12 Text: 12/3/2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 09492321 Numbering: – Type: volume Value: 29 – Type: issue Value: 1 Titles: – TitleFull: European Journal of Medical Research Type: main |
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