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Gastroprotective Efficacy of North African Medicinal Plants: A Review on Their Therapeutic Potential for Peptic Ulcers.

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Title: Gastroprotective Efficacy of North African Medicinal Plants: A Review on Their Therapeutic Potential for Peptic Ulcers.
Authors: Cherrada, Nezar, Chemsa, Ahmed Elkhalifa, Gheraissa, Noura, Laib, Ibtissam, Gueboudji, Zakia, EL‐Shazly, Mohamed, Zaater, Abdelmalek, Abid, Asma, Sweilam, Sherouk Hussein, Emran, Talha Bin, Nani, Sadok, Benamor, Bilal, Ghemam Amara, Djilani, Atoki, Ayomide Victor, Messaoudi, Mohammed
Source: Food Science & Nutrition; Nov2024, Vol. 12 Issue 11, p8793-8824, 32p
Subject Terms: AFRICAN traditional medicine, HELICOBACTER pylori infections, PEPTIC ulcer, LICORICE (Plant), MEDICINAL plants
Abstract: Peptic ulcer disease remains a prevalent gastrointestinal disorder worldwide. Current treatments often have limitations, sparking interest in alternative therapies from medicinal plants. This review examines the gastroprotective potential of 54 North African medicinal plants against peptic ulcers. An extensive literature search was conducted, focusing on plants with preclinical and clinical evidence of anti‐ulcer efficacy and documented use in North African traditional medicine. The review identified several promising plant species, such as licorice (Glycyrrhiza glabra), chamomile (Matricaria chamomilla), olive (Olea europaea), pomegranate (Punica granatum), Aloe vera, and black seed (Nigella sativa), along with their bioactive constituents, including flavonoids, tannins, and terpenoids. These compounds exhibit gastroprotective properties through multiple mechanisms, such as enhancing the gastric mucosal barrier, inhibiting acid secretion, displaying antioxidant and anti‐inflammatory effects, promoting ulcer healing, and combating Helicobacter pylori infection. The evidence presented includes in vitro assays, animal models, and some clinical studies. While many of the 53 plants reviewed demonstrated significant anti‐ulcer effects compared to standard drugs, further clinical research is needed to establish efficacy and safety in humans. The synergistic actions of phytochemical mixtures in medicinal plant extracts likely contribute to their therapeutic potential. This review highlights the role these North African medicinal plants may play in the prevention and treatment of peptic ulcers and identifies promising candidates for further research and development of evidence‐based botanical therapies. [ABSTRACT FROM AUTHOR]
Copyright of Food Science & Nutrition is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Complementary Index
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  Data: Gastroprotective Efficacy of North African Medicinal Plants: A Review on Their Therapeutic Potential for Peptic Ulcers.
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  Data: <searchLink fieldCode="AR" term="%22Cherrada%2C+Nezar%22">Cherrada, Nezar</searchLink><br /><searchLink fieldCode="AR" term="%22Chemsa%2C+Ahmed Elkhalifa%22">Chemsa, Ahmed Elkhalifa</searchLink><br /><searchLink fieldCode="AR" term="%22Gheraissa%2C+Noura%22">Gheraissa, Noura</searchLink><br /><searchLink fieldCode="AR" term="%22Laib%2C+Ibtissam%22">Laib, Ibtissam</searchLink><br /><searchLink fieldCode="AR" term="%22Gueboudji%2C+Zakia%22">Gueboudji, Zakia</searchLink><br /><searchLink fieldCode="AR" term="%22EL‐Shazly%2C+Mohamed%22">EL‐Shazly, Mohamed</searchLink><br /><searchLink fieldCode="AR" term="%22Zaater%2C+Abdelmalek%22">Zaater, Abdelmalek</searchLink><br /><searchLink fieldCode="AR" term="%22Abid%2C+Asma%22">Abid, Asma</searchLink><br /><searchLink fieldCode="AR" term="%22Sweilam%2C+Sherouk Hussein%22">Sweilam, Sherouk Hussein</searchLink><br /><searchLink fieldCode="AR" term="%22Emran%2C+Talha Bin%22">Emran, Talha Bin</searchLink><br /><searchLink fieldCode="AR" term="%22Nani%2C+Sadok%22">Nani, Sadok</searchLink><br /><searchLink fieldCode="AR" term="%22Benamor%2C+Bilal%22">Benamor, Bilal</searchLink><br /><searchLink fieldCode="AR" term="%22Ghemam Amara%2C+Djilani%22">Ghemam Amara, Djilani</searchLink><br /><searchLink fieldCode="AR" term="%22Atoki%2C+Ayomide Victor%22">Atoki, Ayomide Victor</searchLink><br /><searchLink fieldCode="AR" term="%22Messaoudi%2C+Mohammed%22">Messaoudi, Mohammed</searchLink>
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  Data: Food Science & Nutrition; Nov2024, Vol. 12 Issue 11, p8793-8824, 32p
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  Data: <searchLink fieldCode="DE" term="%22AFRICAN+traditional+medicine%22">AFRICAN traditional medicine</searchLink><br /><searchLink fieldCode="DE" term="%22HELICOBACTER+pylori+infections%22">HELICOBACTER pylori infections</searchLink><br /><searchLink fieldCode="DE" term="%22PEPTIC+ulcer%22">PEPTIC ulcer</searchLink><br /><searchLink fieldCode="DE" term="%22LICORICE+%28Plant%29%22">LICORICE (Plant)</searchLink><br /><searchLink fieldCode="DE" term="%22MEDICINAL+plants%22">MEDICINAL plants</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Peptic ulcer disease remains a prevalent gastrointestinal disorder worldwide. Current treatments often have limitations, sparking interest in alternative therapies from medicinal plants. This review examines the gastroprotective potential of 54 North African medicinal plants against peptic ulcers. An extensive literature search was conducted, focusing on plants with preclinical and clinical evidence of anti‐ulcer efficacy and documented use in North African traditional medicine. The review identified several promising plant species, such as licorice (Glycyrrhiza glabra), chamomile (Matricaria chamomilla), olive (Olea europaea), pomegranate (Punica granatum), Aloe vera, and black seed (Nigella sativa), along with their bioactive constituents, including flavonoids, tannins, and terpenoids. These compounds exhibit gastroprotective properties through multiple mechanisms, such as enhancing the gastric mucosal barrier, inhibiting acid secretion, displaying antioxidant and anti‐inflammatory effects, promoting ulcer healing, and combating Helicobacter pylori infection. The evidence presented includes in vitro assays, animal models, and some clinical studies. While many of the 53 plants reviewed demonstrated significant anti‐ulcer effects compared to standard drugs, further clinical research is needed to establish efficacy and safety in humans. The synergistic actions of phytochemical mixtures in medicinal plant extracts likely contribute to their therapeutic potential. This review highlights the role these North African medicinal plants may play in the prevention and treatment of peptic ulcers and identifies promising candidates for further research and development of evidence‐based botanical therapies. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Food Science & Nutrition is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/fsn3.4536
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      – Code: eng
        Text: English
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        PageCount: 32
        StartPage: 8793
    Subjects:
      – SubjectFull: AFRICAN traditional medicine
        Type: general
      – SubjectFull: HELICOBACTER pylori infections
        Type: general
      – SubjectFull: PEPTIC ulcer
        Type: general
      – SubjectFull: LICORICE (Plant)
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      – SubjectFull: MEDICINAL plants
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      – TitleFull: Gastroprotective Efficacy of North African Medicinal Plants: A Review on Their Therapeutic Potential for Peptic Ulcers.
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              M: 11
              Text: Nov2024
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