عوامل مرتبط با پیامد بالینی نامطلوب در کودکان با ترومای مغزی متوسط تا شدید یک مطالعه مشاهده ای گذشته نگر.
| Title: | عوامل مرتبط با پیامد بالینی نامطلوب در کودکان با ترومای مغزی متوسط تا شدید یک مطالعه مشاهده ای گذشته نگر. (Persian) |
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| Alternate Title: | Investigating the Factors Associated With Poor Clinical Outcomes of Children With Moderate to Severe Traumatic Brain Injury: A Retrospective Observational Study. (English) |
| Authors: | بیتا شکری, سیدرضا باقری باو, ساحل اسدزاده, احسان علیمحمدی |
| Source: | Journal of Guilan University of Medical Sciences; Summer2024, Vol. 33 Issue 2, p240-252, 13p |
| Subject Terms: | BRAIN injury treatment, T-test (Statistics), REFLEXES, LOGISTIC regression analysis, COMPUTED tomography, TREATMENT effectiveness, RETROSPECTIVE studies, DESCRIPTIVE statistics, ODDS ratio, CONFIDENCE intervals, CHILDREN |
| Abstract: | Background Traumatic brain injury (TBI) is a leading cause of mortality and disability in pediatric patients. Predicting clinical outcomes following TBI is essential for providing appropriate treatment and improving patient care. Objective This retrospective study investigates the factors associated with clinical outcomes in children with moderate to severe TBI. Methods This study evaluated the clinical data of 374 children with TBI who received treatment at our center between May 2014 and May 2021. Clinical, laboratory, and radiographic data were extracted and analyzed. Clinical outcomes were assessed using the Glasgow outcome scale. The patients were divided into two groups as follows: Subjects with favorable clinical outcomes (Glasgow outcome scale=4 and 5), and subjects with poor clinical outcomes (Glasgow outcome scale=1, 2, and 3). Logistic regression analysis was performed to evaluate the relationship between different variables and clinical outcomes. Results A total of 374 children with moderate to severe TBI were included in the study, consisting of 197 (52.7%) boys and 177 (47.3%) girls. The mean age at the time of trauma was 7.37±3.11 years. According to the logistic regression model, the Glasgow coma score (OR=3.22; 95% CI=1.78-5.24; P<0.001), pupillary response to light (OR=1.97; 95% CI=1.34-2.99; P=0.024), and Rotterdam computed tomography score (OR=2.61; 95% CI=1.72-4.13; P=0.020) were significantly associated with clinical outcomes in children with moderate to severe TBI. Conclusion The Glasgow coma score, pupillary response to light, and Rotterdam computed tomography score may serve as indicators of poor clinical outcomes in children with moderate to severe TBI. These results can be utilized to enhance the management and care provided to these patients. [ABSTRACT FROM AUTHOR] |
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| Database: | Complementary Index |
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