Bacterial Meningoencephalitis in Newborns.
| Title: | Bacterial Meningoencephalitis in Newborns. |
|---|---|
| Authors: | Guarnera, Alessia, Moltoni, Giulia, Dellepiane, Francesco, Lucignani, Giulia, Rossi-Espagnet, Maria Camilla, Campi, Francesca, Auriti, Cinzia, Longo, Daniela |
| Source: | Biomedicines; Nov2024, Vol. 12 Issue 11, p2490, 19p |
| Subject Terms: | STREPTOCOCCUS pyogenes, SYMPTOMS, CHILD patients, STREPTOCOCCUS agalactiae, BACTERIAL meningitis, PRENATAL care |
| Abstract: | Bacterial meningoencephalitis in newborns is a severe and life-threatening pathology, which results from meningeal infection and the subsequent involvement of the brain parenchyma. The severity of the acute onset of symptoms and the risk of neurodevelopmental adverse sequelae in children strongly depend on the timing of the infection, the immunological protection transmitted by the mother to the fetus during pregnancy, and the neonate's inflammatory and immune system response after birth. Although the incidence of neonatal meningitis and meningoencephalitis and related mortality declined in the past twenty years with the improvement of prenatal care and with the introduction of intrapartum antibiotic prophylaxis against Streptococcus beta Hemolyticus group B (Streptococcus Agalactiae) in the 1990s, bacterial meningitis remains the most common form of cerebrospinal fluid infection in pediatric patients. To date, the rate of unfavorable neurological outcomes is still from 20% to 60%, and the possibility of containing its rate strongly depends on early diagnosis, therapy, and a multidisciplinary approach, which involves neonatologists, neurologists, neuroradiologists, and physiotherapists. Neonatal meningitis remains difficult to diagnose because the responsible bacteria vary with gestational age at birth, age at presentation, and environmental context. The clinical presentation, especially in the newborn, is very ambiguous. From a clinical point of view, the definitive test for diagnosis is lumbar puncture in patients with symptoms suggestive of neurological involvement. Therefore, neuroimaging is key for raising clinical suspicion of meningitis or corroborating the diagnosis based on clinical and laboratory data. Our pictorial review offers a practical approach to neonatal meningoencephalitis by describing the epidemiology, the pathophysiology of bacterial meningoencephalitis, defining the indications and suggesting optimized protocols for neuroimaging techniques, and showing the main neuroimaging findings to reach the diagnosis and offering proper follow-up of bacterial meningitis. Moreover, we tried identifying some peculiar MRI patterns related to some bacteria. [ABSTRACT FROM AUTHOR] |
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| Database: | Complementary Index |
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| Items | – Name: Title Label: Title Group: Ti Data: Bacterial Meningoencephalitis in Newborns. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Guarnera%2C+Alessia%22">Guarnera, Alessia</searchLink><br /><searchLink fieldCode="AR" term="%22Moltoni%2C+Giulia%22">Moltoni, Giulia</searchLink><br /><searchLink fieldCode="AR" term="%22Dellepiane%2C+Francesco%22">Dellepiane, Francesco</searchLink><br /><searchLink fieldCode="AR" term="%22Lucignani%2C+Giulia%22">Lucignani, Giulia</searchLink><br /><searchLink fieldCode="AR" term="%22Rossi-Espagnet%2C+Maria+Camilla%22">Rossi-Espagnet, Maria Camilla</searchLink><br /><searchLink fieldCode="AR" term="%22Campi%2C+Francesca%22">Campi, Francesca</searchLink><br /><searchLink fieldCode="AR" term="%22Auriti%2C+Cinzia%22">Auriti, Cinzia</searchLink><br /><searchLink fieldCode="AR" term="%22Longo%2C+Daniela%22">Longo, Daniela</searchLink> – Name: TitleSource Label: Source Group: Src Data: Biomedicines; Nov2024, Vol. 12 Issue 11, p2490, 19p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22STREPTOCOCCUS+pyogenes%22">STREPTOCOCCUS pyogenes</searchLink><br /><searchLink fieldCode="DE" term="%22SYMPTOMS%22">SYMPTOMS</searchLink><br /><searchLink fieldCode="DE" term="%22CHILD+patients%22">CHILD patients</searchLink><br /><searchLink fieldCode="DE" term="%22STREPTOCOCCUS+agalactiae%22">STREPTOCOCCUS agalactiae</searchLink><br /><searchLink fieldCode="DE" term="%22BACTERIAL+meningitis%22">BACTERIAL meningitis</searchLink><br /><searchLink fieldCode="DE" term="%22PRENATAL+care%22">PRENATAL care</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Bacterial meningoencephalitis in newborns is a severe and life-threatening pathology, which results from meningeal infection and the subsequent involvement of the brain parenchyma. The severity of the acute onset of symptoms and the risk of neurodevelopmental adverse sequelae in children strongly depend on the timing of the infection, the immunological protection transmitted by the mother to the fetus during pregnancy, and the neonate's inflammatory and immune system response after birth. Although the incidence of neonatal meningitis and meningoencephalitis and related mortality declined in the past twenty years with the improvement of prenatal care and with the introduction of intrapartum antibiotic prophylaxis against Streptococcus beta Hemolyticus group B (Streptococcus Agalactiae) in the 1990s, bacterial meningitis remains the most common form of cerebrospinal fluid infection in pediatric patients. To date, the rate of unfavorable neurological outcomes is still from 20% to 60%, and the possibility of containing its rate strongly depends on early diagnosis, therapy, and a multidisciplinary approach, which involves neonatologists, neurologists, neuroradiologists, and physiotherapists. Neonatal meningitis remains difficult to diagnose because the responsible bacteria vary with gestational age at birth, age at presentation, and environmental context. The clinical presentation, especially in the newborn, is very ambiguous. From a clinical point of view, the definitive test for diagnosis is lumbar puncture in patients with symptoms suggestive of neurological involvement. Therefore, neuroimaging is key for raising clinical suspicion of meningitis or corroborating the diagnosis based on clinical and laboratory data. Our pictorial review offers a practical approach to neonatal meningoencephalitis by describing the epidemiology, the pathophysiology of bacterial meningoencephalitis, defining the indications and suggesting optimized protocols for neuroimaging techniques, and showing the main neuroimaging findings to reach the diagnosis and offering proper follow-up of bacterial meningitis. Moreover, we tried identifying some peculiar MRI patterns related to some bacteria. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Biomedicines is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/biomedicines12112490 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 19 StartPage: 2490 Subjects: – SubjectFull: STREPTOCOCCUS pyogenes Type: general – SubjectFull: SYMPTOMS Type: general – SubjectFull: CHILD patients Type: general – SubjectFull: STREPTOCOCCUS agalactiae Type: general – SubjectFull: BACTERIAL meningitis Type: general – SubjectFull: PRENATAL care Type: general Titles: – TitleFull: Bacterial Meningoencephalitis in Newborns. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Guarnera, Alessia – PersonEntity: Name: NameFull: Moltoni, Giulia – PersonEntity: Name: NameFull: Dellepiane, Francesco – PersonEntity: Name: NameFull: Lucignani, Giulia – PersonEntity: Name: NameFull: Rossi-Espagnet, Maria Camilla – PersonEntity: Name: NameFull: Campi, Francesca – PersonEntity: Name: NameFull: Auriti, Cinzia – PersonEntity: Name: NameFull: Longo, Daniela IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 22279059 Numbering: – Type: volume Value: 12 – Type: issue Value: 11 Titles: – TitleFull: Biomedicines Type: main |
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