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Serum zonulin and colorectal cancer risk.

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Title: Serum zonulin and colorectal cancer risk.
Authors: Marino, Mirko, Mignozzi, Silvia, Michels, Karin B., Cintolo, Marcello, Penagini, Roberto, Gargari, Giorgio, Ciafardini, Clorinda, Ferraroni, Monica, Patel, Linia, Del Bo', Cristian, Leone, Pierfrancesco, Airoldi, Aldo, Vecchi, Maurizio, Bonzi, Rossella, Oreggia, Barbara, Carnevali, Pietro, Vangeli, Marcello, Mutignani, Massimiliano, Guglielmetti, Simone, Riso, Patrizia
Source: Scientific Reports; 11/15/2024, Vol. 14 Issue 1, p1-9, 9p
Subject Terms: INTESTINAL barrier function, COLON cancer, COLORECTAL cancer, POLYMERASE chain reaction, RECTAL cancer
Abstract: Intestinal permeability has been related to colorectal cancer (CRC) development. Zonulin, a protein able to regulate tight junction function and intestinal permeability, emerges as a promising marker to elucidate the contribution of bacterial translocation in CRC. An Italian case-control study included 77 CRC cases, 72 intestinal adenoma and 76 healthy controls (for a total of 148 tumor-free subjects), aged 20–85. Serum zonulin levels were quantified by ELISA kit and blood 16S rRNA gene copies by DNA extraction and polymerase chain reaction. We applied logistic regression models adjusted for center, sex, age and education. There was a positive association between zonulin and CRC risk. The odds ratio (OR) of CRC for the highest versus lowest tertile of zonulin as compared to tumor-free subjects was 2.36 (95% confidence interval, 1.14–4.86). The ORs were similar in colon and rectal cancers. The OR of colon cancer for the highest versus lowest levels of both zonulin and 16S rRNA gene copies was 4.55. Circulating levels of zonulin were higher in CRC patients compared to tumor-free controls supporting the hypothesis of an interplay of gut barrier dysfunction and bacterial translocation in colorectal carcinogenesis. Zonulin may interact with 16S rRNA gene copies and serve as a further biomarker in the evaluation of CRC diagnosis. [ABSTRACT FROM AUTHOR]
Copyright of Scientific Reports is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Serum zonulin and colorectal cancer risk.
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  Data: <searchLink fieldCode="AR" term="%22Marino%2C+Mirko%22">Marino, Mirko</searchLink><br /><searchLink fieldCode="AR" term="%22Mignozzi%2C+Silvia%22">Mignozzi, Silvia</searchLink><br /><searchLink fieldCode="AR" term="%22Michels%2C+Karin+B%2E%22">Michels, Karin B.</searchLink><br /><searchLink fieldCode="AR" term="%22Cintolo%2C+Marcello%22">Cintolo, Marcello</searchLink><br /><searchLink fieldCode="AR" term="%22Penagini%2C+Roberto%22">Penagini, Roberto</searchLink><br /><searchLink fieldCode="AR" term="%22Gargari%2C+Giorgio%22">Gargari, Giorgio</searchLink><br /><searchLink fieldCode="AR" term="%22Ciafardini%2C+Clorinda%22">Ciafardini, Clorinda</searchLink><br /><searchLink fieldCode="AR" term="%22Ferraroni%2C+Monica%22">Ferraroni, Monica</searchLink><br /><searchLink fieldCode="AR" term="%22Patel%2C+Linia%22">Patel, Linia</searchLink><br /><searchLink fieldCode="AR" term="%22Del+Bo'%2C+Cristian%22">Del Bo', Cristian</searchLink><br /><searchLink fieldCode="AR" term="%22Leone%2C+Pierfrancesco%22">Leone, Pierfrancesco</searchLink><br /><searchLink fieldCode="AR" term="%22Airoldi%2C+Aldo%22">Airoldi, Aldo</searchLink><br /><searchLink fieldCode="AR" term="%22Vecchi%2C+Maurizio%22">Vecchi, Maurizio</searchLink><br /><searchLink fieldCode="AR" term="%22Bonzi%2C+Rossella%22">Bonzi, Rossella</searchLink><br /><searchLink fieldCode="AR" term="%22Oreggia%2C+Barbara%22">Oreggia, Barbara</searchLink><br /><searchLink fieldCode="AR" term="%22Carnevali%2C+Pietro%22">Carnevali, Pietro</searchLink><br /><searchLink fieldCode="AR" term="%22Vangeli%2C+Marcello%22">Vangeli, Marcello</searchLink><br /><searchLink fieldCode="AR" term="%22Mutignani%2C+Massimiliano%22">Mutignani, Massimiliano</searchLink><br /><searchLink fieldCode="AR" term="%22Guglielmetti%2C+Simone%22">Guglielmetti, Simone</searchLink><br /><searchLink fieldCode="AR" term="%22Riso%2C+Patrizia%22">Riso, Patrizia</searchLink>
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  Data: Scientific Reports; 11/15/2024, Vol. 14 Issue 1, p1-9, 9p
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  Data: <searchLink fieldCode="DE" term="%22INTESTINAL+barrier+function%22">INTESTINAL barrier function</searchLink><br /><searchLink fieldCode="DE" term="%22COLON+cancer%22">COLON cancer</searchLink><br /><searchLink fieldCode="DE" term="%22COLORECTAL+cancer%22">COLORECTAL cancer</searchLink><br /><searchLink fieldCode="DE" term="%22POLYMERASE+chain+reaction%22">POLYMERASE chain reaction</searchLink><br /><searchLink fieldCode="DE" term="%22RECTAL+cancer%22">RECTAL cancer</searchLink>
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  Label: Abstract
  Group: Ab
  Data: Intestinal permeability has been related to colorectal cancer (CRC) development. Zonulin, a protein able to regulate tight junction function and intestinal permeability, emerges as a promising marker to elucidate the contribution of bacterial translocation in CRC. An Italian case-control study included 77 CRC cases, 72 intestinal adenoma and 76 healthy controls (for a total of 148 tumor-free subjects), aged 20–85. Serum zonulin levels were quantified by ELISA kit and blood 16S rRNA gene copies by DNA extraction and polymerase chain reaction. We applied logistic regression models adjusted for center, sex, age and education. There was a positive association between zonulin and CRC risk. The odds ratio (OR) of CRC for the highest versus lowest tertile of zonulin as compared to tumor-free subjects was 2.36 (95% confidence interval, 1.14–4.86). The ORs were similar in colon and rectal cancers. The OR of colon cancer for the highest versus lowest levels of both zonulin and 16S rRNA gene copies was 4.55. Circulating levels of zonulin were higher in CRC patients compared to tumor-free controls supporting the hypothesis of an interplay of gut barrier dysfunction and bacterial translocation in colorectal carcinogenesis. Zonulin may interact with 16S rRNA gene copies and serve as a further biomarker in the evaluation of CRC diagnosis. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Scientific Reports is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1038/s41598-024-76697-z
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