Feedback loop LINC00511–YTHDF2–SOX2 regulatory network drives cholangiocarcinoma progression and stemness.
| Title: | Feedback loop LINC00511–YTHDF2–SOX2 regulatory network drives cholangiocarcinoma progression and stemness. |
|---|---|
| Authors: | Guan, Canghai, Zou, Xinlei, Gao, Xin, Liu, Sidi, Gao, Jianjun, Shi, Wujiang, Dong, Qingfu, Jiang, Xingming, Zhong, Xiangyu |
| Source: | MedComm; Nov2024, Vol. 5 Issue 11, p1-19, 19p |
| Subject Terms: | LINCRNA, TRANSCRIPTION factors, SOX2 protein, PI3K/AKT pathway, PROTEIN expression |
| Abstract: | Cholangiocarcinoma (CCA) was identified as a malignant tumor with rising incidence and mortality rates, and the roles of long noncoding RNA (lncRNA) in CCA remained not entirely clear. In this study, LINC00511 had high expression in CCA, which was closely related to poor prognosis. Knockdown of LINC00511 significantly inhibited cell malignant biological behaviors. It also affected the stemness of CCA, evidenced by decreased SOX2 protein expression. Moreover, the study revealed the interaction of LINC00511, YTHDF2, and SOX2 in CCA. Specifically, LINC00511 facilitated the formation of a complex with YTHDF2 on SOX2 mRNA, which uniquely enhances the mRNA's stability through m6A methylation sites. This stabilization appears crucial for maintaining malignant behaviors in CCA cells. Additionally, LINC00511 modulated SOX2 expression via the PI3K/AKT signaling pathway. Meanwhile, SOX2 can also promote LINC00511 expression as an upstream transcription factor, thereby confirming a positive feedback loop formed by LINC00511, YTHDF2, and SOX2, which plays a significant role in the occurrence and development of CCA. Finally, the study successfully constructed two patient‐derived xenograft models, revealing the vital role of LINC00511 in CCA development. In summary, this research provides a comprehensive understanding of the role of LINC00511 in the pathogenesis of CCA. [ABSTRACT FROM AUTHOR] |
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| Database: | Complementary Index |
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| Items | – Name: Title Label: Title Group: Ti Data: Feedback loop LINC00511–YTHDF2–SOX2 regulatory network drives cholangiocarcinoma progression and stemness. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Guan%2C+Canghai%22">Guan, Canghai</searchLink><br /><searchLink fieldCode="AR" term="%22Zou%2C+Xinlei%22">Zou, Xinlei</searchLink><br /><searchLink fieldCode="AR" term="%22Gao%2C+Xin%22">Gao, Xin</searchLink><br /><searchLink fieldCode="AR" term="%22Liu%2C+Sidi%22">Liu, Sidi</searchLink><br /><searchLink fieldCode="AR" term="%22Gao%2C+Jianjun%22">Gao, Jianjun</searchLink><br /><searchLink fieldCode="AR" term="%22Shi%2C+Wujiang%22">Shi, Wujiang</searchLink><br /><searchLink fieldCode="AR" term="%22Dong%2C+Qingfu%22">Dong, Qingfu</searchLink><br /><searchLink fieldCode="AR" term="%22Jiang%2C+Xingming%22">Jiang, Xingming</searchLink><br /><searchLink fieldCode="AR" term="%22Zhong%2C+Xiangyu%22">Zhong, Xiangyu</searchLink> – Name: TitleSource Label: Source Group: Src Data: MedComm; Nov2024, Vol. 5 Issue 11, p1-19, 19p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22LINCRNA%22">LINCRNA</searchLink><br /><searchLink fieldCode="DE" term="%22TRANSCRIPTION+factors%22">TRANSCRIPTION factors</searchLink><br /><searchLink fieldCode="DE" term="%22SOX2+protein%22">SOX2 protein</searchLink><br /><searchLink fieldCode="DE" term="%22PI3K%2FAKT+pathway%22">PI3K/AKT pathway</searchLink><br /><searchLink fieldCode="DE" term="%22PROTEIN+expression%22">PROTEIN expression</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Cholangiocarcinoma (CCA) was identified as a malignant tumor with rising incidence and mortality rates, and the roles of long noncoding RNA (lncRNA) in CCA remained not entirely clear. In this study, LINC00511 had high expression in CCA, which was closely related to poor prognosis. Knockdown of LINC00511 significantly inhibited cell malignant biological behaviors. It also affected the stemness of CCA, evidenced by decreased SOX2 protein expression. Moreover, the study revealed the interaction of LINC00511, YTHDF2, and SOX2 in CCA. Specifically, LINC00511 facilitated the formation of a complex with YTHDF2 on SOX2 mRNA, which uniquely enhances the mRNA's stability through m6A methylation sites. This stabilization appears crucial for maintaining malignant behaviors in CCA cells. Additionally, LINC00511 modulated SOX2 expression via the PI3K/AKT signaling pathway. Meanwhile, SOX2 can also promote LINC00511 expression as an upstream transcription factor, thereby confirming a positive feedback loop formed by LINC00511, YTHDF2, and SOX2, which plays a significant role in the occurrence and development of CCA. Finally, the study successfully constructed two patient‐derived xenograft models, revealing the vital role of LINC00511 in CCA development. In summary, this research provides a comprehensive understanding of the role of LINC00511 in the pathogenesis of CCA. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of MedComm is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mco2.743 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 19 StartPage: 1 Subjects: – SubjectFull: LINCRNA Type: general – SubjectFull: TRANSCRIPTION factors Type: general – SubjectFull: SOX2 protein Type: general – SubjectFull: PI3K/AKT pathway Type: general – SubjectFull: PROTEIN expression Type: general Titles: – TitleFull: Feedback loop LINC00511–YTHDF2–SOX2 regulatory network drives cholangiocarcinoma progression and stemness. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Guan, Canghai – PersonEntity: Name: NameFull: Zou, Xinlei – PersonEntity: Name: NameFull: Gao, Xin – PersonEntity: Name: NameFull: Liu, Sidi – PersonEntity: Name: NameFull: Gao, Jianjun – PersonEntity: Name: NameFull: Shi, Wujiang – PersonEntity: Name: NameFull: Dong, Qingfu – PersonEntity: Name: NameFull: Jiang, Xingming – PersonEntity: Name: NameFull: Zhong, Xiangyu IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 26882663 Numbering: – Type: volume Value: 5 – Type: issue Value: 11 Titles: – TitleFull: MedComm Type: main |
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