Tubarial salivary glands show a low relative contribution to functional salivary gland tissue mass.
| Title: | Tubarial salivary glands show a low relative contribution to functional salivary gland tissue mass. |
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| Authors: | Ling, Sui wai, van der Veldt, Astrid, Segbers, Marcel, Luiting, Henk, Brabander, Tessa, Verburg, Frederik |
| Source: | Annals of Nuclear Medicine; Nov2024, Vol. 38 Issue 11, p913-918, 6p |
| Abstract: | Background: In 2021, the tubarial salivary glands (TSGs) were newly identified on prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) as macroscopic glands in the nasopharyngeal wall. However, the relative contribution of the TSGs to the total salivary gland function, and consequently on the development of xerostomia after external beam radiotherapy (EBRT) or PSMA-targeted radionuclide therapy (RNT) is not known. Therefore, we aimed to determine the presence of the TSGs and to quantify uptake in the TSGs on PSMA PET. Methods: Qualitative and quantitative analyses were performed on 68Ga-PSMA-11 PET/CT scans of 100 patients with prostate cancer. The mean and maximum standardized uptake value (SUVmean and SUVmax) in the TSGs were measured and compared to the parotid, submandibular and sublingual salivary glands (PSGs, SMSGs and SLSGs, respectively). Furthermore, proportional function of the TSGs was compared to the PSGs, SMSGs and SLSGs based on the total organ PSMA (TO-PSMA). Results: The TSGs were visible on 95% of the 68Ga-PSMA-11 PET/CT scans. The normalized median SUVmean and SUVmax was significantly higher for the PSGs (p < 0.001) and SMSGs (p < 0.001) compared to the TSGs, but not for the SLSGs (p = 0.242 and p = 0.300, respectively). The normalized median TO-PSMA was significantly higher for the PSGs (p < 0.001) and SMSGs (p < 0.001), and significant lower for the SLSGs (p < 0.001) compared the TSGs. Conclusions: The SUVmean, SUVmax and TO-PSMA of the TSGs were most comparable to the SLSGs. However, the measured PSMA uptake may be disproportional towards the saliva production. Therefore, future studies should focus on the relation between PSMA uptake and salivary function before and after PSMA therapy. [ABSTRACT FROM AUTHOR] |
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| Database: | Complementary Index |
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| Items | – Name: Title Label: Title Group: Ti Data: Tubarial salivary glands show a low relative contribution to functional salivary gland tissue mass. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ling%2C+Sui+wai%22">Ling, Sui wai</searchLink><br /><searchLink fieldCode="AR" term="%22van+der+Veldt%2C+Astrid%22">van der Veldt, Astrid</searchLink><br /><searchLink fieldCode="AR" term="%22Segbers%2C+Marcel%22">Segbers, Marcel</searchLink><br /><searchLink fieldCode="AR" term="%22Luiting%2C+Henk%22">Luiting, Henk</searchLink><br /><searchLink fieldCode="AR" term="%22Brabander%2C+Tessa%22">Brabander, Tessa</searchLink><br /><searchLink fieldCode="AR" term="%22Verburg%2C+Frederik%22">Verburg, Frederik</searchLink> – Name: TitleSource Label: Source Group: Src Data: Annals of Nuclear Medicine; Nov2024, Vol. 38 Issue 11, p913-918, 6p – Name: Abstract Label: Abstract Group: Ab Data: Background: In 2021, the tubarial salivary glands (TSGs) were newly identified on prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) as macroscopic glands in the nasopharyngeal wall. However, the relative contribution of the TSGs to the total salivary gland function, and consequently on the development of xerostomia after external beam radiotherapy (EBRT) or PSMA-targeted radionuclide therapy (RNT) is not known. Therefore, we aimed to determine the presence of the TSGs and to quantify uptake in the TSGs on PSMA PET. Methods: Qualitative and quantitative analyses were performed on <superscript>68</superscript>Ga-PSMA-11 PET/CT scans of 100 patients with prostate cancer. The mean and maximum standardized uptake value (SUVmean and SUVmax) in the TSGs were measured and compared to the parotid, submandibular and sublingual salivary glands (PSGs, SMSGs and SLSGs, respectively). Furthermore, proportional function of the TSGs was compared to the PSGs, SMSGs and SLSGs based on the total organ PSMA (TO-PSMA). Results: The TSGs were visible on 95% of the <superscript>68</superscript>Ga-PSMA-11 PET/CT scans. The normalized median SUVmean and SUVmax was significantly higher for the PSGs (p < 0.001) and SMSGs (p < 0.001) compared to the TSGs, but not for the SLSGs (p = 0.242 and p = 0.300, respectively). The normalized median TO-PSMA was significantly higher for the PSGs (p < 0.001) and SMSGs (p < 0.001), and significant lower for the SLSGs (p < 0.001) compared the TSGs. Conclusions: The SUVmean, SUVmax and TO-PSMA of the TSGs were most comparable to the SLSGs. However, the measured PSMA uptake may be disproportional towards the saliva production. Therefore, future studies should focus on the relation between PSMA uptake and salivary function before and after PSMA therapy. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Annals of Nuclear Medicine is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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