Bibliographic Details
| Title: |
Low-Molecular-Weight Compounds Produced by the Intestinal Microbiota and Cardiovascular Disease. |
| Authors: |
Cuervo, Lorena, McAlpine, Patrick L., Olano, Carlos, Fernández, Javier, Lombó, Felipe |
| Source: |
International Journal of Molecular Sciences; Oct2024, Vol. 25 Issue 19, p10397, 49p |
| Subject Terms: |
SHORT-chain fatty acids, BILE acids, PHENYLACETIC acid, GUT microbiome, DEVELOPED countries, TRIMETHYLAMINE oxide, HYDROGEN sulfide |
| Abstract: |
Cardiovascular disease is the main cause of mortality in industrialized countries, with over 500 million people affected worldwide. In this work, the roles of low-molecular-weight metabolites originating from the gut microbiome, such as short-chain fatty acids, hydrogen sulfide, trimethylamine, phenylacetic acid, secondary bile acids, indoles, different gases, neurotransmitters, vitamins, and complex lipids, are discussed in relation to their CVD-promoting or preventing activities. Molecules of mixed microbial and human hepatic origin, such as trimethylamine N-oxide and phenylacetylglutamine, are also presented. Finally, dietary agents with cardioprotective effects, such as probiotics, prebiotics, mono- and poly-unsaturated fatty acids, carotenoids, and polyphenols, are also discussed. A special emphasis is given to their gut microbiota-modulating properties. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
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