Prognostic factors and validation of the histologic chronicity score for C3 glomerulopathy: a registry analysis.
| Title: | Prognostic factors and validation of the histologic chronicity score for C3 glomerulopathy: a registry analysis. |
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| Authors: | Mirioglu, Safak, Cebeci, Egemen, Yazici, Halil, Derici, Ulver, Sahin, Gulizar, Coban, Ganime, Eren, Necmi, Gungor, Ozkan, Dede, Fatih, Dincer, Tamer, Turkmen, Kultigin, Basturk, Taner, Duranay, Murat, Arikan, Hakki, Tunca, Onur, Elcioglu, Omer Celal, Tatar, Erhan, Aydin, Zeki, Oygar, Deren, Demir, Serap |
| Source: | Clinical Kidney Journal; Aug2024, Vol. 17 Issue 8, p1-11, 11p |
| Subject Terms: | RECEIVER operating characteristic curves, CHRONIC kidney failure, PROGNOSIS, STATISTICAL significance, REGRESSION analysis |
| Abstract: | Background Data on the prognostic factors for C3 glomerulopathy (C3G) are limited, and validation of the new C3G histologic index (C3G-HI) in different settings is still needed. We aimed to evaluate the chronicity score of C3G-HI and probable prognostic factors in our population. Methods In this registry study, 74 patients from 20 centers with adequate follow-up data were included. Total chronicity score (TCS) was calculated according to percentages of glomerulosclerosis, interstitial fibrosis, tubular atrophy, and presence of arterio- and arteriolosclerosis. Primary composite outcome was defined as doubling of serum creatinine from baseline, undergoing dialysis or transplantation, development of stage 5 chronic kidney disease, or death. Results Median age was 34 [interquartile range (IQR) 24–46] years, and 39 patients (52.7%) were male. Median follow-up duration was 36 (IQR 12–60) months, and median TCS was 3 (IQR 1–5). Overall, 19 patients (25.7%) experienced primary composite outcome. Multivariate Cox regression model showed that only hemoglobin [adjusted HR (aHR) 0.67, 95% confidence interval 0.46–0.97, P = .035] predicted primary composite outcome, and TCS fell short of the statistical significance (aHR 1.26, 0.97–1.64, P = .08). Receiver operating characteristic analysis demonstrated that TCS showed an area under the curve value of 0.68 (0.56–0.78, P = .028) in discriminating primary composite outcome at 3 years, and 3-year kidney survival was lower in patients with TCS ≥4 (72.4%) compared with TCS <4 (91.1%) in Kaplan–Meier analysis (P = .036). Conclusions Low hemoglobin levels predicted dismal outcomes in patients with C3G. TCS ≥4 was associated with a worse 3-year kidney survival, which validated the 3-year prognostic value of the TCS of C3G-HI in our population. [ABSTRACT FROM AUTHOR] |
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| Database: | Complementary Index |
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| Items | – Name: Title Label: Title Group: Ti Data: Prognostic factors and validation of the histologic chronicity score for C3 glomerulopathy: a registry analysis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Mirioglu%2C+Safak%22">Mirioglu, Safak</searchLink><br /><searchLink fieldCode="AR" term="%22Cebeci%2C+Egemen%22">Cebeci, Egemen</searchLink><br /><searchLink fieldCode="AR" term="%22Yazici%2C+Halil%22">Yazici, Halil</searchLink><br /><searchLink fieldCode="AR" term="%22Derici%2C+Ulver%22">Derici, Ulver</searchLink><br /><searchLink fieldCode="AR" term="%22Sahin%2C+Gulizar%22">Sahin, Gulizar</searchLink><br /><searchLink fieldCode="AR" term="%22Coban%2C+Ganime%22">Coban, Ganime</searchLink><br /><searchLink fieldCode="AR" term="%22Eren%2C+Necmi%22">Eren, Necmi</searchLink><br /><searchLink fieldCode="AR" term="%22Gungor%2C+Ozkan%22">Gungor, Ozkan</searchLink><br /><searchLink fieldCode="AR" term="%22Dede%2C+Fatih%22">Dede, Fatih</searchLink><br /><searchLink fieldCode="AR" term="%22Dincer%2C+Tamer%22">Dincer, Tamer</searchLink><br /><searchLink fieldCode="AR" term="%22Turkmen%2C+Kultigin%22">Turkmen, Kultigin</searchLink><br /><searchLink fieldCode="AR" term="%22Basturk%2C+Taner%22">Basturk, Taner</searchLink><br /><searchLink fieldCode="AR" term="%22Duranay%2C+Murat%22">Duranay, Murat</searchLink><br /><searchLink fieldCode="AR" term="%22Arikan%2C+Hakki%22">Arikan, Hakki</searchLink><br /><searchLink fieldCode="AR" term="%22Tunca%2C+Onur%22">Tunca, Onur</searchLink><br /><searchLink fieldCode="AR" term="%22Elcioglu%2C+Omer+Celal%22">Elcioglu, Omer Celal</searchLink><br /><searchLink fieldCode="AR" term="%22Tatar%2C+Erhan%22">Tatar, Erhan</searchLink><br /><searchLink fieldCode="AR" term="%22Aydin%2C+Zeki%22">Aydin, Zeki</searchLink><br /><searchLink fieldCode="AR" term="%22Oygar%2C+Deren%22">Oygar, Deren</searchLink><br /><searchLink fieldCode="AR" term="%22Demir%2C+Serap%22">Demir, Serap</searchLink> – Name: TitleSource Label: Source Group: Src Data: Clinical Kidney Journal; Aug2024, Vol. 17 Issue 8, p1-11, 11p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22RECEIVER+operating+characteristic+curves%22">RECEIVER operating characteristic curves</searchLink><br /><searchLink fieldCode="DE" term="%22CHRONIC+kidney+failure%22">CHRONIC kidney failure</searchLink><br /><searchLink fieldCode="DE" term="%22PROGNOSIS%22">PROGNOSIS</searchLink><br /><searchLink fieldCode="DE" term="%22STATISTICAL+significance%22">STATISTICAL significance</searchLink><br /><searchLink fieldCode="DE" term="%22REGRESSION+analysis%22">REGRESSION analysis</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background Data on the prognostic factors for C3 glomerulopathy (C3G) are limited, and validation of the new C3G histologic index (C3G-HI) in different settings is still needed. We aimed to evaluate the chronicity score of C3G-HI and probable prognostic factors in our population. Methods In this registry study, 74 patients from 20 centers with adequate follow-up data were included. Total chronicity score (TCS) was calculated according to percentages of glomerulosclerosis, interstitial fibrosis, tubular atrophy, and presence of arterio- and arteriolosclerosis. Primary composite outcome was defined as doubling of serum creatinine from baseline, undergoing dialysis or transplantation, development of stage 5 chronic kidney disease, or death. Results Median age was 34 [interquartile range (IQR) 24–46] years, and 39 patients (52.7%) were male. Median follow-up duration was 36 (IQR 12–60) months, and median TCS was 3 (IQR 1–5). Overall, 19 patients (25.7%) experienced primary composite outcome. Multivariate Cox regression model showed that only hemoglobin [adjusted HR (aHR) 0.67, 95% confidence interval 0.46–0.97, P = .035] predicted primary composite outcome, and TCS fell short of the statistical significance (aHR 1.26, 0.97–1.64, P = .08). Receiver operating characteristic analysis demonstrated that TCS showed an area under the curve value of 0.68 (0.56–0.78, P = .028) in discriminating primary composite outcome at 3 years, and 3-year kidney survival was lower in patients with TCS ≥4 (72.4%) compared with TCS <4 (91.1%) in Kaplan–Meier analysis (P = .036). Conclusions Low hemoglobin levels predicted dismal outcomes in patients with C3G. TCS ≥4 was associated with a worse 3-year kidney survival, which validated the 3-year prognostic value of the TCS of C3G-HI in our population. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Clinical Kidney Journal is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1093/ckj/sfae077 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 1 Subjects: – SubjectFull: RECEIVER operating characteristic curves Type: general – SubjectFull: CHRONIC kidney failure Type: general – SubjectFull: PROGNOSIS Type: general – SubjectFull: STATISTICAL significance Type: general – SubjectFull: REGRESSION analysis Type: general Titles: – TitleFull: Prognostic factors and validation of the histologic chronicity score for C3 glomerulopathy: a registry analysis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Mirioglu, Safak – PersonEntity: Name: NameFull: Cebeci, Egemen – PersonEntity: Name: NameFull: Yazici, Halil – PersonEntity: Name: NameFull: Derici, Ulver – PersonEntity: Name: NameFull: Sahin, Gulizar – PersonEntity: Name: NameFull: Coban, Ganime – PersonEntity: Name: NameFull: Eren, Necmi – PersonEntity: Name: NameFull: Gungor, Ozkan – PersonEntity: Name: NameFull: Dede, Fatih – PersonEntity: Name: NameFull: Dincer, Tamer – PersonEntity: Name: NameFull: Turkmen, Kultigin – PersonEntity: Name: NameFull: Basturk, Taner – PersonEntity: Name: NameFull: Duranay, Murat – PersonEntity: Name: NameFull: Arikan, Hakki – PersonEntity: Name: NameFull: Tunca, Onur – PersonEntity: Name: NameFull: Elcioglu, Omer Celal – PersonEntity: Name: NameFull: Tatar, Erhan – PersonEntity: Name: NameFull: Aydin, Zeki – PersonEntity: Name: NameFull: Oygar, Deren – PersonEntity: Name: NameFull: Demir, Serap IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 20488505 Numbering: – Type: volume Value: 17 – Type: issue Value: 8 Titles: – TitleFull: Clinical Kidney Journal Type: main |
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