Antioxidant, Antitumoral, Antimicrobial, and Prebiotic Activity of Magnetite Nanoparticles Loaded with Bee Pollen/Bee Bread Extracts and 5-Fluorouracil.
| Title: | Antioxidant, Antitumoral, Antimicrobial, and Prebiotic Activity of Magnetite Nanoparticles Loaded with Bee Pollen/Bee Bread Extracts and 5-Fluorouracil. |
|---|---|
| Authors: | Ilie, Cornelia-Ioana, Spoiala, Angela, Chircov, Cristina, Dolete, Georgiana, Oprea, Ovidiu-Cristian, Vasile, Bogdan-Stefan, Crainiceanu, Simona Adriana, Nicoara, Adrian-Ionut, Marinas, Ioana Cristina, Stan, Miruna Silvia, Ditu, Lia-Mara, Ficai, Anton, Oprea, Eliza |
| Source: | Antioxidants; Aug2024, Vol. 13 Issue 8, p895, 29p |
| Subject Terms: | BEE pollen, PROPOLIS, FOURIER transform infrared spectroscopy, DRUG delivery systems, ALTERNATIVE treatment for cancer |
| Abstract: | The gut microbiota dysbiosis that often occurs in cancer therapy requires more efficient treatment options to be developed. In this concern, the present research approach is to develop drug delivery systems based on magnetite nanoparticles (MNPs) as nanocarriers for bioactive compounds. First, MNPs were synthesized through the spraying-assisted coprecipitation method, followed by loading bee pollen or bee bread extracts and an antitumoral drug (5-fluorouracil/5-FU). The loaded-MNPs were morphologically and structurally characterized through transmission electron microscopy (TEM), selected area electron diffraction (SAED), scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Dynamic Light Scattering (DLS), and thermogravimetric analysis. UV-Vis spectroscopy was applied to establish the release profiles and antioxidant activity. Furthermore, the antibacterial and antitumoral activity of loaded-MNPs was assessed. The results demonstrate that MNPs with antioxidant, antibacterial, antiproliferative, and prebiotic properties are obtained. Moreover, the data highlight the improvement of 5-FU antibacterial activity by loading on the MNPs' surface and the synergistic effects between the anticancer drug and phenolic compounds (PCs). In addition, the prolonged release behavior of PCs for many hours (70–75 h) after the release of 5-FU from the developed nanocarriers is an advantage, at least from the point of view of the antioxidant activity of PCs. Considering the enhancement of L. rhamnosus MF9 growth and antitumoral activity, this study developed promising drug delivery alternatives for colorectal cancer therapy. [ABSTRACT FROM AUTHOR] |
| Copyright of Antioxidants is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Complementary Index |
| FullText | Text: Availability: 0 CustomLinks: – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edb&genre=article&issn=20763921&ISBN=&volume=13&issue=8&date=20240801&spage=895&pages=895-923&title=Antioxidants&atitle=Antioxidant%2C%20Antitumoral%2C%20Antimicrobial%2C%20and%20Prebiotic%20Activity%20of%20Magnetite%20Nanoparticles%20Loaded%20with%20Bee%20Pollen%2FBee%20Bread%20Extracts%20and%205-Fluorouracil.&aulast=Ilie%2C%20Cornelia-Ioana&id=DOI:10.3390/antiox13080895 Name: Full Text Finder (for New FTF UI) (s8985755) Category: fullText Text: Find It @ SCU Libraries MouseOverText: Find It @ SCU Libraries |
|---|---|
| Header | DbId: edb DbLabel: Complementary Index An: 179378212 RelevancyScore: 1041 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 1040.51647949219 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Antioxidant, Antitumoral, Antimicrobial, and Prebiotic Activity of Magnetite Nanoparticles Loaded with Bee Pollen/Bee Bread Extracts and 5-Fluorouracil. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ilie%2C+Cornelia-Ioana%22">Ilie, Cornelia-Ioana</searchLink><br /><searchLink fieldCode="AR" term="%22Spoiala%2C+Angela%22">Spoiala, Angela</searchLink><br /><searchLink fieldCode="AR" term="%22Chircov%2C+Cristina%22">Chircov, Cristina</searchLink><br /><searchLink fieldCode="AR" term="%22Dolete%2C+Georgiana%22">Dolete, Georgiana</searchLink><br /><searchLink fieldCode="AR" term="%22Oprea%2C+Ovidiu-Cristian%22">Oprea, Ovidiu-Cristian</searchLink><br /><searchLink fieldCode="AR" term="%22Vasile%2C+Bogdan-Stefan%22">Vasile, Bogdan-Stefan</searchLink><br /><searchLink fieldCode="AR" term="%22Crainiceanu%2C+Simona+Adriana%22">Crainiceanu, Simona Adriana</searchLink><br /><searchLink fieldCode="AR" term="%22Nicoara%2C+Adrian-Ionut%22">Nicoara, Adrian-Ionut</searchLink><br /><searchLink fieldCode="AR" term="%22Marinas%2C+Ioana+Cristina%22">Marinas, Ioana Cristina</searchLink><br /><searchLink fieldCode="AR" term="%22Stan%2C+Miruna+Silvia%22">Stan, Miruna Silvia</searchLink><br /><searchLink fieldCode="AR" term="%22Ditu%2C+Lia-Mara%22">Ditu, Lia-Mara</searchLink><br /><searchLink fieldCode="AR" term="%22Ficai%2C+Anton%22">Ficai, Anton</searchLink><br /><searchLink fieldCode="AR" term="%22Oprea%2C+Eliza%22">Oprea, Eliza</searchLink> – Name: TitleSource Label: Source Group: Src Data: Antioxidants; Aug2024, Vol. 13 Issue 8, p895, 29p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22BEE+pollen%22">BEE pollen</searchLink><br /><searchLink fieldCode="DE" term="%22PROPOLIS%22">PROPOLIS</searchLink><br /><searchLink fieldCode="DE" term="%22FOURIER+transform+infrared+spectroscopy%22">FOURIER transform infrared spectroscopy</searchLink><br /><searchLink fieldCode="DE" term="%22DRUG+delivery+systems%22">DRUG delivery systems</searchLink><br /><searchLink fieldCode="DE" term="%22ALTERNATIVE+treatment+for+cancer%22">ALTERNATIVE treatment for cancer</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The gut microbiota dysbiosis that often occurs in cancer therapy requires more efficient treatment options to be developed. In this concern, the present research approach is to develop drug delivery systems based on magnetite nanoparticles (MNPs) as nanocarriers for bioactive compounds. First, MNPs were synthesized through the spraying-assisted coprecipitation method, followed by loading bee pollen or bee bread extracts and an antitumoral drug (5-fluorouracil/5-FU). The loaded-MNPs were morphologically and structurally characterized through transmission electron microscopy (TEM), selected area electron diffraction (SAED), scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Dynamic Light Scattering (DLS), and thermogravimetric analysis. UV-Vis spectroscopy was applied to establish the release profiles and antioxidant activity. Furthermore, the antibacterial and antitumoral activity of loaded-MNPs was assessed. The results demonstrate that MNPs with antioxidant, antibacterial, antiproliferative, and prebiotic properties are obtained. Moreover, the data highlight the improvement of 5-FU antibacterial activity by loading on the MNPs' surface and the synergistic effects between the anticancer drug and phenolic compounds (PCs). In addition, the prolonged release behavior of PCs for many hours (70–75 h) after the release of 5-FU from the developed nanocarriers is an advantage, at least from the point of view of the antioxidant activity of PCs. Considering the enhancement of L. rhamnosus MF9 growth and antitumoral activity, this study developed promising drug delivery alternatives for colorectal cancer therapy. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Antioxidants is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edb&AN=179378212 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/antiox13080895 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 29 StartPage: 895 Subjects: – SubjectFull: BEE pollen Type: general – SubjectFull: PROPOLIS Type: general – SubjectFull: FOURIER transform infrared spectroscopy Type: general – SubjectFull: DRUG delivery systems Type: general – SubjectFull: ALTERNATIVE treatment for cancer Type: general Titles: – TitleFull: Antioxidant, Antitumoral, Antimicrobial, and Prebiotic Activity of Magnetite Nanoparticles Loaded with Bee Pollen/Bee Bread Extracts and 5-Fluorouracil. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ilie, Cornelia-Ioana – PersonEntity: Name: NameFull: Spoiala, Angela – PersonEntity: Name: NameFull: Chircov, Cristina – PersonEntity: Name: NameFull: Dolete, Georgiana – PersonEntity: Name: NameFull: Oprea, Ovidiu-Cristian – PersonEntity: Name: NameFull: Vasile, Bogdan-Stefan – PersonEntity: Name: NameFull: Crainiceanu, Simona Adriana – PersonEntity: Name: NameFull: Nicoara, Adrian-Ionut – PersonEntity: Name: NameFull: Marinas, Ioana Cristina – PersonEntity: Name: NameFull: Stan, Miruna Silvia – PersonEntity: Name: NameFull: Ditu, Lia-Mara – PersonEntity: Name: NameFull: Ficai, Anton – PersonEntity: Name: NameFull: Oprea, Eliza IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 20763921 Numbering: – Type: volume Value: 13 – Type: issue Value: 8 Titles: – TitleFull: Antioxidants Type: main |
| ResultId | 1 |