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Evaluation of the Interaction between Carvacrol and Thymol, Major Compounds of Ptychotis verticillata Essential Oil: Antioxidant, Anti-Inflammatory and Anticancer Activities against Breast Cancer Lines.

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Title: Evaluation of the Interaction between Carvacrol and Thymol, Major Compounds of Ptychotis verticillata Essential Oil: Antioxidant, Anti-Inflammatory and Anticancer Activities against Breast Cancer Lines.
Authors: Taibi, Mohamed, Elbouzidi, Amine, Haddou, Mounir, Baraich, Abdellah, Ou-Yahia, Douaae, Bellaouchi, Reda, Mothana, Ramzi A., Al-Yousef, Hanan M., Asehraou, Abdeslam, Addi, Mohamed, Guerrouj, Bouchra El, Chaabane, Khalid
Source: Life (2075-1729); Aug2024, Vol. 14 Issue 8, p1037, 19p
Subject Terms: BREAST cancer, CYTOTOXINS, VITAMIN C, NATUROPATHY, ANTI-inflammatory agents, CARVACROL, THYMOL
Abstract: The objective of this study was to evaluate the antioxidant, anti-inflammatory, and anticancer properties of thymol, carvacrol, and their equimolar mixture. Antioxidant activities were assessed using the DPPH, ABTS, and ORAC methods. The thymol/carvacrol mixture exhibited significant synergism, surpassing the individual compounds and ascorbic acid in DPPH (IC50 = 43.82 ± 2.41 µg/mL) and ABTS (IC50 = 23.29 ± 0.71 µg/mL) assays. Anti-inflammatory activity was evaluated by inhibiting the 5-LOX, COX-1, and COX-2 enzymes. The equimolar mixture showed the strongest inhibition of 5-LOX (IC50 = 8.46 ± 0.92 µg/mL) and substantial inhibition of COX-1 (IC50 = 15.23 ± 2.34 µg/mL) and COX-2 (IC50 = 14.53 ± 2.42 µg/mL), indicating a synergistic effect. Anticancer activity was tested on MCF-7, MDA-MB-231, and MDA-MB-436 breast cancer cell lines using the MTT assay. The thymol/carvacrol mixture demonstrated superior cytotoxicity (IC50 = 0.92–1.70 µg/mL) and increased selectivity compared to cisplatin, with high selectivity indices (144.88–267.71). These results underscore the promising therapeutic potential of the thymol/carvacrol combination, particularly for its synergistic antioxidant, anti-inflammatory, and anticancer properties against breast cancer. This study paves the way for developing natural therapies against breast cancer and other conditions associated with oxidative stress and inflammation, leveraging the synergistic effects of natural compounds like thymol and carvacrol. [ABSTRACT FROM AUTHOR]
Copyright of Life (2075-1729) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Complementary Index
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  Data: Evaluation of the Interaction between Carvacrol and Thymol, Major Compounds of Ptychotis verticillata Essential Oil: Antioxidant, Anti-Inflammatory and Anticancer Activities against Breast Cancer Lines.
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  Data: <searchLink fieldCode="AR" term="%22Taibi%2C+Mohamed%22">Taibi, Mohamed</searchLink><br /><searchLink fieldCode="AR" term="%22Elbouzidi%2C+Amine%22">Elbouzidi, Amine</searchLink><br /><searchLink fieldCode="AR" term="%22Haddou%2C+Mounir%22">Haddou, Mounir</searchLink><br /><searchLink fieldCode="AR" term="%22Baraich%2C+Abdellah%22">Baraich, Abdellah</searchLink><br /><searchLink fieldCode="AR" term="%22Ou-Yahia%2C+Douaae%22">Ou-Yahia, Douaae</searchLink><br /><searchLink fieldCode="AR" term="%22Bellaouchi%2C+Reda%22">Bellaouchi, Reda</searchLink><br /><searchLink fieldCode="AR" term="%22Mothana%2C+Ramzi+A%2E%22">Mothana, Ramzi A.</searchLink><br /><searchLink fieldCode="AR" term="%22Al-Yousef%2C+Hanan+M%2E%22">Al-Yousef, Hanan M.</searchLink><br /><searchLink fieldCode="AR" term="%22Asehraou%2C+Abdeslam%22">Asehraou, Abdeslam</searchLink><br /><searchLink fieldCode="AR" term="%22Addi%2C+Mohamed%22">Addi, Mohamed</searchLink><br /><searchLink fieldCode="AR" term="%22Guerrouj%2C+Bouchra+El%22">Guerrouj, Bouchra El</searchLink><br /><searchLink fieldCode="AR" term="%22Chaabane%2C+Khalid%22">Chaabane, Khalid</searchLink>
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  Data: Life (2075-1729); Aug2024, Vol. 14 Issue 8, p1037, 19p
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  Data: <searchLink fieldCode="DE" term="%22BREAST+cancer%22">BREAST cancer</searchLink><br /><searchLink fieldCode="DE" term="%22CYTOTOXINS%22">CYTOTOXINS</searchLink><br /><searchLink fieldCode="DE" term="%22VITAMIN+C%22">VITAMIN C</searchLink><br /><searchLink fieldCode="DE" term="%22NATUROPATHY%22">NATUROPATHY</searchLink><br /><searchLink fieldCode="DE" term="%22ANTI-inflammatory+agents%22">ANTI-inflammatory agents</searchLink><br /><searchLink fieldCode="DE" term="%22CARVACROL%22">CARVACROL</searchLink><br /><searchLink fieldCode="DE" term="%22THYMOL%22">THYMOL</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The objective of this study was to evaluate the antioxidant, anti-inflammatory, and anticancer properties of thymol, carvacrol, and their equimolar mixture. Antioxidant activities were assessed using the DPPH, ABTS, and ORAC methods. The thymol/carvacrol mixture exhibited significant synergism, surpassing the individual compounds and ascorbic acid in DPPH (IC<subscript>50</subscript> = 43.82 ± 2.41 µg/mL) and ABTS (IC<subscript>50</subscript> = 23.29 ± 0.71 µg/mL) assays. Anti-inflammatory activity was evaluated by inhibiting the 5-LOX, COX-1, and COX-2 enzymes. The equimolar mixture showed the strongest inhibition of 5-LOX (IC<subscript>50</subscript> = 8.46 ± 0.92 µg/mL) and substantial inhibition of COX-1 (IC<subscript>50</subscript> = 15.23 ± 2.34 µg/mL) and COX-2 (IC50 = 14.53 ± 2.42 µg/mL), indicating a synergistic effect. Anticancer activity was tested on MCF-7, MDA-MB-231, and MDA-MB-436 breast cancer cell lines using the MTT assay. The thymol/carvacrol mixture demonstrated superior cytotoxicity (IC<subscript>50</subscript> = 0.92–1.70 µg/mL) and increased selectivity compared to cisplatin, with high selectivity indices (144.88–267.71). These results underscore the promising therapeutic potential of the thymol/carvacrol combination, particularly for its synergistic antioxidant, anti-inflammatory, and anticancer properties against breast cancer. This study paves the way for developing natural therapies against breast cancer and other conditions associated with oxidative stress and inflammation, leveraging the synergistic effects of natural compounds like thymol and carvacrol. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Life (2075-1729) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3390/life14081037
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      – Code: eng
        Text: English
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        PageCount: 19
        StartPage: 1037
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      – SubjectFull: BREAST cancer
        Type: general
      – SubjectFull: CYTOTOXINS
        Type: general
      – SubjectFull: VITAMIN C
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      – SubjectFull: CARVACROL
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      – SubjectFull: THYMOL
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      – TitleFull: Evaluation of the Interaction between Carvacrol and Thymol, Major Compounds of Ptychotis verticillata Essential Oil: Antioxidant, Anti-Inflammatory and Anticancer Activities against Breast Cancer Lines.
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              M: 08
              Text: Aug2024
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