Gastric intestinal metaplasia regression in United States population: A retrospective longitudinal study.
| Title: | Gastric intestinal metaplasia regression in United States population: A retrospective longitudinal study. |
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| Authors: | Ahmed, Akram I, El Sabagh, Ahmed, Caplan, Claire, Lee, Arielle, Cho, Won K |
| Source: | JGH Open; Aug2024, Vol. 8 Issue 8, p1-6, 6p |
| Subject Terms: | METAPLASIA, INTESTINES, PEPTIC ulcer, AFRICAN Americans, LONGITUDINAL method |
| Geographic Terms: | UNITED States |
| Abstract: | Background and Aim: Gastric cancer is a health concern and contributes to cancer‐related deaths. Gastric intestinal metaplasia (GIM) is a premalignant lesion of gastric cancer. Currently, factors associated with GIM regression are under‐investigated. This study aims to assess the rate of GIM regression and identify factors associated with it. Methods: This study was conducted at Medstar Washington Hospital Center. We included patients who had GIM between January 2015 and December 2020. Population was divided into GIM persistence or regression. Data included demographics, esophagogastroduodenoscopy findings, Helicobacter pylori status, and laboratory results. Statistical analyses included Kaplan–Meier and Cox proportional models to explore predictors of GIM regression. Results: Among 2375 patients, 9.1% had GIM. Notably, 85 patients had GIM regression and 132 patients had persistent GIM. African Americans constituted (75%) of the regression group and (76%) of the persistence group. Peptic ulcer disease (PUD) was noted in 12.9% of the regression group at baseline, and 5.9% at follow‐up; the persistence group showed 11.4% at baseline and 5.3% at follow‐up (P = 0.89). Regression analysis revealed that the presence of PUD was associated with a higher rate of regression (hazard ratio [HR] 2.46, P = 0.013). Smoking status showed lower rates of regression (HR 0.54 and 0.62, P = 0.038 and 0.169). On gastric mapping, African Americans, Hispanics, and individuals of other races/ethnicities displayed lower rates of GIM regression (HR 0.68, 0.78 and 0.69). Conclusion: PUD was associated with a higher rate of GIM regression, while smoking showed lower regression rates. Results provide insights into factors influencing GIM regression in African American population and may inform future surveillance and treatment strategies. [ABSTRACT FROM AUTHOR] |
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| Database: | Complementary Index |
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| Items | – Name: Title Label: Title Group: Ti Data: Gastric intestinal metaplasia regression in United States population: A retrospective longitudinal study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ahmed%2C+Akram+I%22">Ahmed, Akram I</searchLink><br /><searchLink fieldCode="AR" term="%22El+Sabagh%2C+Ahmed%22">El Sabagh, Ahmed</searchLink><br /><searchLink fieldCode="AR" term="%22Caplan%2C+Claire%22">Caplan, Claire</searchLink><br /><searchLink fieldCode="AR" term="%22Lee%2C+Arielle%22">Lee, Arielle</searchLink><br /><searchLink fieldCode="AR" term="%22Cho%2C+Won+K%22">Cho, Won K</searchLink> – Name: TitleSource Label: Source Group: Src Data: JGH Open; Aug2024, Vol. 8 Issue 8, p1-6, 6p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22METAPLASIA%22">METAPLASIA</searchLink><br /><searchLink fieldCode="DE" term="%22INTESTINES%22">INTESTINES</searchLink><br /><searchLink fieldCode="DE" term="%22PEPTIC+ulcer%22">PEPTIC ulcer</searchLink><br /><searchLink fieldCode="DE" term="%22AFRICAN+Americans%22">AFRICAN Americans</searchLink><br /><searchLink fieldCode="DE" term="%22LONGITUDINAL+method%22">LONGITUDINAL method</searchLink> – Name: SubjectGeographic Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22UNITED+States%22">UNITED States</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background and Aim: Gastric cancer is a health concern and contributes to cancer‐related deaths. Gastric intestinal metaplasia (GIM) is a premalignant lesion of gastric cancer. Currently, factors associated with GIM regression are under‐investigated. This study aims to assess the rate of GIM regression and identify factors associated with it. Methods: This study was conducted at Medstar Washington Hospital Center. We included patients who had GIM between January 2015 and December 2020. Population was divided into GIM persistence or regression. Data included demographics, esophagogastroduodenoscopy findings, Helicobacter pylori status, and laboratory results. Statistical analyses included Kaplan–Meier and Cox proportional models to explore predictors of GIM regression. Results: Among 2375 patients, 9.1% had GIM. Notably, 85 patients had GIM regression and 132 patients had persistent GIM. African Americans constituted (75%) of the regression group and (76%) of the persistence group. Peptic ulcer disease (PUD) was noted in 12.9% of the regression group at baseline, and 5.9% at follow‐up; the persistence group showed 11.4% at baseline and 5.3% at follow‐up (P = 0.89). Regression analysis revealed that the presence of PUD was associated with a higher rate of regression (hazard ratio [HR] 2.46, P = 0.013). Smoking status showed lower rates of regression (HR 0.54 and 0.62, P = 0.038 and 0.169). On gastric mapping, African Americans, Hispanics, and individuals of other races/ethnicities displayed lower rates of GIM regression (HR 0.68, 0.78 and 0.69). Conclusion: PUD was associated with a higher rate of GIM regression, while smoking showed lower regression rates. Results provide insights into factors influencing GIM regression in African American population and may inform future surveillance and treatment strategies. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of JGH Open is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/jgh3.70005 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 1 Subjects: – SubjectFull: UNITED States Type: general – SubjectFull: METAPLASIA Type: general – SubjectFull: INTESTINES Type: general – SubjectFull: PEPTIC ulcer Type: general – SubjectFull: AFRICAN Americans Type: general – SubjectFull: LONGITUDINAL method Type: general Titles: – TitleFull: Gastric intestinal metaplasia regression in United States population: A retrospective longitudinal study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ahmed, Akram I – PersonEntity: Name: NameFull: El Sabagh, Ahmed – PersonEntity: Name: NameFull: Caplan, Claire – PersonEntity: Name: NameFull: Lee, Arielle – PersonEntity: Name: NameFull: Cho, Won K IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 23979070 Numbering: – Type: volume Value: 8 – Type: issue Value: 8 Titles: – TitleFull: JGH Open Type: main |
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