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Expectations of preventative benefits and risk behaviors in a randomized trial evaluating oral HIV preexposure prophylaxis candidates.

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Title: Expectations of preventative benefits and risk behaviors in a randomized trial evaluating oral HIV preexposure prophylaxis candidates.
Authors: Sugarman, Jeremy, Weir, Brian W., Dun, Chen, Gulick, Roy M., Wilkin, Timothy J., Mayer, Kenneth H., McCauley, Marybeth, Weinfurt, Kevin P.
Source: AIDS Care; Aug2024, Vol. 36 Issue 8, p1172-1178, 7p
Subject Terms: HIV prevention, PREVENTIVE medicine, PATIENT selection, SAFETY, SEXUALLY transmitted diseases, PATIENT compliance, HEALTH attitudes, RISK-taking behavior, ANTIRETROVIRAL agents, DATA analysis, SECONDARY analysis, CLINICAL trials, HUMAN research subjects, LOGISTIC regression analysis, QUESTIONNAIRES, CHI-squared test, PRE-exposure prophylaxis, MEN who have sex with men, ODDS ratio, CISGENDER people, STATISTICS, CONFIDENCE intervals, DRUGS
Abstract: When participants enrolled in an HIV prevention trial hold a preventive misconception (PM) – expectations that experimental interventions will confer protection from HIV infection – they may engage in behaviors that increase their risk of acquiring HIV. This can raise ethical concerns about whether those enrolled in the trial understand the nature of participation and their safety. Consequently, we systematically evaluated the prevalence of PM and its association with risk behaviors in a trial examining three candidate regimens for oral HIV pre-exposure prophylaxis in which all participants received at least one antiretroviral agent. Overall, trial participants exhibited relatively high preventive expectations that may be associated with an increase in risk behaviors among men who have sex with men. In addition, we identified substantial site variability in PM that necessitates future research to uncover its source. This will allow appropriate measures to be taken to mitigate PM and help ensure that participants have an accurate understanding of the potential risks and benefits of trial participation throughout the course of a trial. [ABSTRACT FROM AUTHOR]
Copyright of AIDS Care is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Expectations of preventative benefits and risk behaviors in a randomized trial evaluating oral HIV preexposure prophylaxis candidates.
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  Data: <searchLink fieldCode="AR" term="%22Sugarman%2C+Jeremy%22">Sugarman, Jeremy</searchLink><br /><searchLink fieldCode="AR" term="%22Weir%2C+Brian+W%2E%22">Weir, Brian W.</searchLink><br /><searchLink fieldCode="AR" term="%22Dun%2C+Chen%22">Dun, Chen</searchLink><br /><searchLink fieldCode="AR" term="%22Gulick%2C+Roy+M%2E%22">Gulick, Roy M.</searchLink><br /><searchLink fieldCode="AR" term="%22Wilkin%2C+Timothy+J%2E%22">Wilkin, Timothy J.</searchLink><br /><searchLink fieldCode="AR" term="%22Mayer%2C+Kenneth+H%2E%22">Mayer, Kenneth H.</searchLink><br /><searchLink fieldCode="AR" term="%22McCauley%2C+Marybeth%22">McCauley, Marybeth</searchLink><br /><searchLink fieldCode="AR" term="%22Weinfurt%2C+Kevin+P%2E%22">Weinfurt, Kevin P.</searchLink>
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  Data: AIDS Care; Aug2024, Vol. 36 Issue 8, p1172-1178, 7p
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  Data: <searchLink fieldCode="DE" term="%22HIV+prevention%22">HIV prevention</searchLink><br /><searchLink fieldCode="DE" term="%22PREVENTIVE+medicine%22">PREVENTIVE medicine</searchLink><br /><searchLink fieldCode="DE" term="%22PATIENT+selection%22">PATIENT selection</searchLink><br /><searchLink fieldCode="DE" term="%22SAFETY%22">SAFETY</searchLink><br /><searchLink fieldCode="DE" term="%22SEXUALLY+transmitted+diseases%22">SEXUALLY transmitted diseases</searchLink><br /><searchLink fieldCode="DE" term="%22PATIENT+compliance%22">PATIENT compliance</searchLink><br /><searchLink fieldCode="DE" term="%22HEALTH+attitudes%22">HEALTH attitudes</searchLink><br /><searchLink fieldCode="DE" term="%22RISK-taking+behavior%22">RISK-taking behavior</searchLink><br /><searchLink fieldCode="DE" term="%22ANTIRETROVIRAL+agents%22">ANTIRETROVIRAL agents</searchLink><br /><searchLink fieldCode="DE" term="%22DATA+analysis%22">DATA analysis</searchLink><br /><searchLink fieldCode="DE" term="%22SECONDARY+analysis%22">SECONDARY analysis</searchLink><br /><searchLink fieldCode="DE" term="%22CLINICAL+trials%22">CLINICAL trials</searchLink><br /><searchLink fieldCode="DE" term="%22HUMAN+research+subjects%22">HUMAN research subjects</searchLink><br /><searchLink fieldCode="DE" term="%22LOGISTIC+regression+analysis%22">LOGISTIC regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22QUESTIONNAIRES%22">QUESTIONNAIRES</searchLink><br /><searchLink fieldCode="DE" term="%22CHI-squared+test%22">CHI-squared test</searchLink><br /><searchLink fieldCode="DE" term="%22PRE-exposure+prophylaxis%22">PRE-exposure prophylaxis</searchLink><br /><searchLink fieldCode="DE" term="%22MEN+who+have+sex+with+men%22">MEN who have sex with men</searchLink><br /><searchLink fieldCode="DE" term="%22ODDS+ratio%22">ODDS ratio</searchLink><br /><searchLink fieldCode="DE" term="%22CISGENDER+people%22">CISGENDER people</searchLink><br /><searchLink fieldCode="DE" term="%22STATISTICS%22">STATISTICS</searchLink><br /><searchLink fieldCode="DE" term="%22CONFIDENCE+intervals%22">CONFIDENCE intervals</searchLink><br /><searchLink fieldCode="DE" term="%22DRUGS%22">DRUGS</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: When participants enrolled in an HIV prevention trial hold a preventive misconception (PM) – expectations that experimental interventions will confer protection from HIV infection – they may engage in behaviors that increase their risk of acquiring HIV. This can raise ethical concerns about whether those enrolled in the trial understand the nature of participation and their safety. Consequently, we systematically evaluated the prevalence of PM and its association with risk behaviors in a trial examining three candidate regimens for oral HIV pre-exposure prophylaxis in which all participants received at least one antiretroviral agent. Overall, trial participants exhibited relatively high preventive expectations that may be associated with an increase in risk behaviors among men who have sex with men. In addition, we identified substantial site variability in PM that necessitates future research to uncover its source. This will allow appropriate measures to be taken to mitigate PM and help ensure that participants have an accurate understanding of the potential risks and benefits of trial participation throughout the course of a trial. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of AIDS Care is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1080/09540121.2024.2332446
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 7
        StartPage: 1172
    Subjects:
      – SubjectFull: HIV prevention
        Type: general
      – SubjectFull: PREVENTIVE medicine
        Type: general
      – SubjectFull: PATIENT selection
        Type: general
      – SubjectFull: SAFETY
        Type: general
      – SubjectFull: SEXUALLY transmitted diseases
        Type: general
      – SubjectFull: PATIENT compliance
        Type: general
      – SubjectFull: HEALTH attitudes
        Type: general
      – SubjectFull: RISK-taking behavior
        Type: general
      – SubjectFull: ANTIRETROVIRAL agents
        Type: general
      – SubjectFull: DATA analysis
        Type: general
      – SubjectFull: SECONDARY analysis
        Type: general
      – SubjectFull: CLINICAL trials
        Type: general
      – SubjectFull: HUMAN research subjects
        Type: general
      – SubjectFull: LOGISTIC regression analysis
        Type: general
      – SubjectFull: QUESTIONNAIRES
        Type: general
      – SubjectFull: CHI-squared test
        Type: general
      – SubjectFull: PRE-exposure prophylaxis
        Type: general
      – SubjectFull: MEN who have sex with men
        Type: general
      – SubjectFull: ODDS ratio
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      – SubjectFull: CISGENDER people
        Type: general
      – SubjectFull: STATISTICS
        Type: general
      – SubjectFull: CONFIDENCE intervals
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      – SubjectFull: DRUGS
        Type: general
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      – TitleFull: Expectations of preventative benefits and risk behaviors in a randomized trial evaluating oral HIV preexposure prophylaxis candidates.
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              Text: Aug2024
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