An Entropy Based Observational Study to Assess the Dosage of Propofol Required for Induction of Anaesthesia by Varying the Time Intervals between Fentanyl and Propofol Administration.
| Title: | An Entropy Based Observational Study to Assess the Dosage of Propofol Required for Induction of Anaesthesia by Varying the Time Intervals between Fentanyl and Propofol Administration. |
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| Authors: | Shivaram, Chetan, Bhat, Suresh, Santha, Neeta |
| Source: | Journal of Medical Sciences (1011-4564); Mar/Apr2024, Vol. 44 Issue 2, p80-85, 6p |
| Subject Terms: | PROPOFOL, FENTANYL, ENTROPY, SCIENTIFIC observation, ANESTHESIA |
| Abstract: | Background: Propofol is the preferred drug for the induction of anesthesia in many centers. However, its ubiquitous use is hampered by adverse effects. The rationale behind our study is to prove that whether the administration of an opioid drug before propofol induction, lowers the amount of propofol requirement for balanced anesthesia, and enhances hemodynamic stability. Aim: The present study intends to know the consequence of the differing time intervals between the administration of fentanyl and propofol on the dosage of propofol required to achieve induction of general anesthesia. Methods: In this observational study, 84 patients were included in the study. Patients who received propofol immediately after fentanyl injection were included in Group 1, whereas patients who received propofol at 3 min and 6 min after fentanyl injection, respectively, were grouped as Group 2 and Group 3. The total propofol required, the hemodynamic variations and the entropy values were recorded. SSPS version 25.09 (IBM) was used for statistical analysis. Results: In this study, it was observed that there was a significant reduction in propofol requirement in Group 2 and Group 3 compared with Group 1. The incidence of hypotension was seen in about 42.9% of Group 1 when compared to Group 2 and 3, which was 28.6% and 17.8%, respectively. Furthermore, the entropy values in Group 3 were initially higher and later were comparable in all the groups. Conclusion: Our study concluded that as the duration between the administration of propofol and fentanyl increases, the hemodynamic stability also increases and there is no variation in the depth of anesthesia attained in the distinct study population. [ABSTRACT FROM AUTHOR] |
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| Database: | Complementary Index |
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| Items | – Name: Title Label: Title Group: Ti Data: An Entropy Based Observational Study to Assess the Dosage of Propofol Required for Induction of Anaesthesia by Varying the Time Intervals between Fentanyl and Propofol Administration. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Shivaram%2C+Chetan%22">Shivaram, Chetan</searchLink><br /><searchLink fieldCode="AR" term="%22Bhat%2C+Suresh%22">Bhat, Suresh</searchLink><br /><searchLink fieldCode="AR" term="%22Santha%2C+Neeta%22">Santha, Neeta</searchLink> – Name: TitleSource Label: Source Group: Src Data: Journal of Medical Sciences (1011-4564); Mar/Apr2024, Vol. 44 Issue 2, p80-85, 6p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22PROPOFOL%22">PROPOFOL</searchLink><br /><searchLink fieldCode="DE" term="%22FENTANYL%22">FENTANYL</searchLink><br /><searchLink fieldCode="DE" term="%22ENTROPY%22">ENTROPY</searchLink><br /><searchLink fieldCode="DE" term="%22SCIENTIFIC+observation%22">SCIENTIFIC observation</searchLink><br /><searchLink fieldCode="DE" term="%22ANESTHESIA%22">ANESTHESIA</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: Propofol is the preferred drug for the induction of anesthesia in many centers. However, its ubiquitous use is hampered by adverse effects. The rationale behind our study is to prove that whether the administration of an opioid drug before propofol induction, lowers the amount of propofol requirement for balanced anesthesia, and enhances hemodynamic stability. Aim: The present study intends to know the consequence of the differing time intervals between the administration of fentanyl and propofol on the dosage of propofol required to achieve induction of general anesthesia. Methods: In this observational study, 84 patients were included in the study. Patients who received propofol immediately after fentanyl injection were included in Group 1, whereas patients who received propofol at 3 min and 6 min after fentanyl injection, respectively, were grouped as Group 2 and Group 3. The total propofol required, the hemodynamic variations and the entropy values were recorded. SSPS version 25.09 (IBM) was used for statistical analysis. Results: In this study, it was observed that there was a significant reduction in propofol requirement in Group 2 and Group 3 compared with Group 1. The incidence of hypotension was seen in about 42.9% of Group 1 when compared to Group 2 and 3, which was 28.6% and 17.8%, respectively. Furthermore, the entropy values in Group 3 were initially higher and later were comparable in all the groups. Conclusion: Our study concluded that as the duration between the administration of propofol and fentanyl increases, the hemodynamic stability also increases and there is no variation in the depth of anesthesia attained in the distinct study population. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Journal of Medical Sciences (1011-4564) is the property of Wolters Kluwer India Pvt Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.4103/jmedsci.jmedsci_47_23 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 80 Subjects: – SubjectFull: PROPOFOL Type: general – SubjectFull: FENTANYL Type: general – SubjectFull: ENTROPY Type: general – SubjectFull: SCIENTIFIC observation Type: general – SubjectFull: ANESTHESIA Type: general Titles: – TitleFull: An Entropy Based Observational Study to Assess the Dosage of Propofol Required for Induction of Anaesthesia by Varying the Time Intervals between Fentanyl and Propofol Administration. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Shivaram, Chetan – PersonEntity: Name: NameFull: Bhat, Suresh – PersonEntity: Name: NameFull: Santha, Neeta IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar/Apr2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 10114564 Numbering: – Type: volume Value: 44 – Type: issue Value: 2 Titles: – TitleFull: Journal of Medical Sciences (1011-4564) Type: main |
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