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Effects of Lumbar Stabilization and Graded Activity Exercises on Selected Biochemical Mediators and Clinical Outcomes in Patients With Non-specific Chronic Low Back Pain.

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Title: Effects of Lumbar Stabilization and Graded Activity Exercises on Selected Biochemical Mediators and Clinical Outcomes in Patients With Non-specific Chronic Low Back Pain.
Authors: Oghumu, Saturday Nicholas, Chris Okafor, Udoka Arinze, Salu, Olumuyiwa Babalola, Tella, Bosede Abidemi
Source: Iranian Rehabilitation Journal; Dec2023, Vol. 21 Issue 4, p663-694, 31p
Subject Terms: CHRONIC pain, LUMBAR pain, BIOMARKERS, INTERLEUKINS, INFERENTIAL statistics, STRETCH (Physiology), KRUSKAL-Wallis Test, PAIN measurement, CONFIDENCE intervals, ANTHROPOMETRY, ONE-way analysis of variance, CELL receptors, BLOOD collection, VISUAL analog scale, COPING Strategies Questionnaire, MANN Whitney U Test, TREATMENT effectiveness, RANDOMIZED controlled trials, FUNCTIONAL assessment, COMPARATIVE studies, T-test (Statistics), PRE-tests & post-tests, ATTENTION, BLIND experiment, ENZYME-linked immunosorbent assay, QUESTIONNAIRES, DESCRIPTIVE statistics, REPEATED measures design, LUMBAR vertebrae, OXIDOREDUCTASES, STATISTICAL sampling, PAIN catastrophizing, COGNITIVE testing, PSYCHOLOGICAL adaptation, DATA analysis software, FRIEDMAN test (Statistics), EXERCISE therapy, PAIN management, LONGITUDINAL method, BLOOD
Geographic Terms: IRAN
Abstract: Objectives: This study aims to investigate the effects of lumbar stabilization exercise (LSE) and graded activity exercise (GAE) on concentrations of interleukin (IL) 1A (IL1A), IL18 receptor 1 (IL18R1), IL18 receptor accessory protein (IL18RAP), IL-6, cyclooxygenase-2 (COX2), and clinical outcomes of pain intensity, disability, catastrophizing, diverting-attention, cognitivecoping and pain-reinterpretation in patients with non-specific chronic low back pain (NSCLBP). Methods: This study was a single-blind parallel trial with an adaptive trial design. Fiftyfour patients with NSCLBP were randomly assigned to LSE and GAE treatment groups. Demographic and anthropometric characteristics were measured. Treatments were administered twice a week for 10 weeks. The concentrations of IL1A, IL18R1, IL18RAP, IL-6, and COX2 of patients were assessed at four time points with enzyme-linked immunosorbent assay. Pain, disability, catastrophizing, diverting attention, cognitive coping, and pain reinterpretation were assessed at three time points with valid instruments. The responsiveness of the biochemical mediators to LSE and GAE was determined with a Bayesian one-way analysis of variance (ANOVA). Data were analyzed with descriptive and inferential statistics at P<0.05. Results: The concentrations of IL1A, IL18R1, IL18RAP, and COX2 were unresponsive (Bayes factor [BF]<1) to LSE and GAE, while IL-6 concentrations were responsive (Bayes factor [BF]>1). The concentrations of IL-6 increased significantly (P<0.05) after LSE with a significant reduction (P<0.05) in pain, disability, and catastrophizing, while the concentration of IL-6 increased significantly (P<0.05) after GAE with a significant reduction (P<0.05) in pain, and disability. Effects of LSE and GAE on IL-6 concentrations, pain, and disability were comparable (P>0.05). Catastrophizing of patients with LSE was significantly less (P<0.05) compared to GAE. Discussion: LSE increases IL-6 concentrations in NSCLBP patients while reducing pain, disability, and catastrophizing, while GAE increases IL-6 concentrations and reduces pain and disability. IL-6 concentrations, pain, and disability of patients were similar after LSE and GAE. Patients catastrophize less with LSE compared to GAE, hence LSE shows more beneficial effects for patients with NSCLBP than GAE. [ABSTRACT FROM AUTHOR]
Copyright of Iranian Rehabilitation Journal is the property of Negah Institute for Social Research & Scientific Communication and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Effects of Lumbar Stabilization and Graded Activity Exercises on Selected Biochemical Mediators and Clinical Outcomes in Patients With Non-specific Chronic Low Back Pain.
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  Data: Objectives: This study aims to investigate the effects of lumbar stabilization exercise (LSE) and graded activity exercise (GAE) on concentrations of interleukin (IL) 1A (IL1A), IL18 receptor 1 (IL18R1), IL18 receptor accessory protein (IL18RAP), IL-6, cyclooxygenase-2 (COX2), and clinical outcomes of pain intensity, disability, catastrophizing, diverting-attention, cognitivecoping and pain-reinterpretation in patients with non-specific chronic low back pain (NSCLBP). Methods: This study was a single-blind parallel trial with an adaptive trial design. Fiftyfour patients with NSCLBP were randomly assigned to LSE and GAE treatment groups. Demographic and anthropometric characteristics were measured. Treatments were administered twice a week for 10 weeks. The concentrations of IL1A, IL18R1, IL18RAP, IL-6, and COX2 of patients were assessed at four time points with enzyme-linked immunosorbent assay. Pain, disability, catastrophizing, diverting attention, cognitive coping, and pain reinterpretation were assessed at three time points with valid instruments. The responsiveness of the biochemical mediators to LSE and GAE was determined with a Bayesian one-way analysis of variance (ANOVA). Data were analyzed with descriptive and inferential statistics at P&lt;0.05. Results: The concentrations of IL1A, IL18R1, IL18RAP, and COX2 were unresponsive (Bayes factor [BF]&lt;1) to LSE and GAE, while IL-6 concentrations were responsive (Bayes factor [BF]&gt;1). The concentrations of IL-6 increased significantly (P&lt;0.05) after LSE with a significant reduction (P&lt;0.05) in pain, disability, and catastrophizing, while the concentration of IL-6 increased significantly (P&lt;0.05) after GAE with a significant reduction (P&lt;0.05) in pain, and disability. Effects of LSE and GAE on IL-6 concentrations, pain, and disability were comparable (P&gt;0.05). Catastrophizing of patients with LSE was significantly less (P&lt;0.05) compared to GAE. Discussion: LSE increases IL-6 concentrations in NSCLBP patients while reducing pain, disability, and catastrophizing, while GAE increases IL-6 concentrations and reduces pain and disability. IL-6 concentrations, pain, and disability of patients were similar after LSE and GAE. Patients catastrophize less with LSE compared to GAE, hence LSE shows more beneficial effects for patients with NSCLBP than GAE. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Iranian Rehabilitation Journal is the property of Negah Institute for Social Research &amp; Scientific Communication and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder&#39;s express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.32598/irj.21.4.1733.3
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 31
        StartPage: 663
    Subjects:
      – SubjectFull: IRAN
        Type: general
      – SubjectFull: CHRONIC pain
        Type: general
      – SubjectFull: LUMBAR pain
        Type: general
      – SubjectFull: BIOMARKERS
        Type: general
      – SubjectFull: INTERLEUKINS
        Type: general
      – SubjectFull: INFERENTIAL statistics
        Type: general
      – SubjectFull: STRETCH (Physiology)
        Type: general
      – SubjectFull: KRUSKAL-Wallis Test
        Type: general
      – SubjectFull: PAIN measurement
        Type: general
      – SubjectFull: CONFIDENCE intervals
        Type: general
      – SubjectFull: ANTHROPOMETRY
        Type: general
      – SubjectFull: ONE-way analysis of variance
        Type: general
      – SubjectFull: CELL receptors
        Type: general
      – SubjectFull: BLOOD collection
        Type: general
      – SubjectFull: VISUAL analog scale
        Type: general
      – SubjectFull: COPING Strategies Questionnaire
        Type: general
      – SubjectFull: MANN Whitney U Test
        Type: general
      – SubjectFull: TREATMENT effectiveness
        Type: general
      – SubjectFull: RANDOMIZED controlled trials
        Type: general
      – SubjectFull: FUNCTIONAL assessment
        Type: general
      – SubjectFull: COMPARATIVE studies
        Type: general
      – SubjectFull: T-test (Statistics)
        Type: general
      – SubjectFull: PRE-tests & post-tests
        Type: general
      – SubjectFull: ATTENTION
        Type: general
      – SubjectFull: BLIND experiment
        Type: general
      – SubjectFull: ENZYME-linked immunosorbent assay
        Type: general
      – SubjectFull: QUESTIONNAIRES
        Type: general
      – SubjectFull: DESCRIPTIVE statistics
        Type: general
      – SubjectFull: REPEATED measures design
        Type: general
      – SubjectFull: LUMBAR vertebrae
        Type: general
      – SubjectFull: OXIDOREDUCTASES
        Type: general
      – SubjectFull: STATISTICAL sampling
        Type: general
      – SubjectFull: PAIN catastrophizing
        Type: general
      – SubjectFull: COGNITIVE testing
        Type: general
      – SubjectFull: PSYCHOLOGICAL adaptation
        Type: general
      – SubjectFull: DATA analysis software
        Type: general
      – SubjectFull: FRIEDMAN test (Statistics)
        Type: general
      – SubjectFull: EXERCISE therapy
        Type: general
      – SubjectFull: PAIN management
        Type: general
      – SubjectFull: LONGITUDINAL method
        Type: general
      – SubjectFull: BLOOD
        Type: general
    Titles:
      – TitleFull: Effects of Lumbar Stabilization and Graded Activity Exercises on Selected Biochemical Mediators and Clinical Outcomes in Patients With Non-specific Chronic Low Back Pain.
        Type: main
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      – PersonEntity:
          Name:
            NameFull: Oghumu, Saturday Nicholas
      – PersonEntity:
          Name:
            NameFull: Chris Okafor, Udoka Arinze
      – PersonEntity:
          Name:
            NameFull: Salu, Olumuyiwa Babalola
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            NameFull: Tella, Bosede Abidemi
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          Dates:
            – D: 01
              M: 12
              Text: Dec2023
              Type: published
              Y: 2023
          Identifiers:
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              Value: 17353602
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              Value: 21
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              Value: 4
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            – TitleFull: Iranian Rehabilitation Journal
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