Efficacy and Safety of Dual Antiplatelet Therapy with the Routine Use of Prasugrel for Flow Diversion of Cerebral Unruptured Aneurysms.
| Title: | Efficacy and Safety of Dual Antiplatelet Therapy with the Routine Use of Prasugrel for Flow Diversion of Cerebral Unruptured Aneurysms. |
|---|---|
| Authors: | Suyama, Kenichiro, Nakahara, Ichiro, Matsumoto, Shoji, Morioka, Jun, Tanabe, Jun, Hasebe, Akiko, Watanabe, Sadayoshi |
| Source: | Clinical Neuroradiology; Mar2024, Vol. 34 Issue 1, p201-208, 8p |
| Abstract: | Purpose: Prasugrel is not approved for patients treated with flow diverters, which have a high metal coverage ratio. However, robust antiplatelet therapy with prasugrel may prevent thromboembolic complications. We administered prasugrel and aspirin to all patients treated with flow diverters and reported the safety of the antiplatelet therapy regimen. Methods: This retrospective, single-center study evaluated the angiographic and clinical data of consecutive patients treated with flow diverters for cerebral unruptured aneurysms between June 2020 and May 2022. All patients received dual antiplatelet therapy, including prasugrel and aspirin. The administration of prasugrel ended 3 or 6 months after the procedure, whereas aspirin use continued for at least 12 months. Periprocedural complications (< 30 days post-procedure) and delayed complications (> 30 days post-procedure) were recorded. Results: During the study period, 120 unruptured aneurysms were treated with flow diverters in 110 patients. All patients, except one, survived longer than 12 months after the procedure. The rate of thromboembolic complications was 6.4%, and more than half of the patients had transient symptoms; one (0.9%) had a major ischemic stroke. One patient (0.9%) each had an asymptomatic, small subarachnoid hemorrhage and significant hemorrhagic complications with melena. The rate of permanent neurological deficits was 1.8%, and the mortality rate was 0.9%. Conclusions: Dual antiplatelet therapy comprising routine use of prasugrel and aspirin for flow diverter-implanted patients possibly contributed to a low rate of thromboembolic complications and low risk of hemorrhagic complications. [ABSTRACT FROM AUTHOR] |
| Copyright of Clinical Neuroradiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Complementary Index |
| FullText | Text: Availability: 0 CustomLinks: – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edb&genre=article&issn=18691439&ISBN=&volume=34&issue=1&date=20240301&spage=201&pages=201-208&title=Clinical Neuroradiology&atitle=Efficacy%20and%20Safety%20of%20Dual%20Antiplatelet%20Therapy%20with%20the%20Routine%20Use%20of%20Prasugrel%20for%20Flow%20Diversion%20of%20Cerebral%20Unruptured%20Aneurysms.&aulast=Suyama%2C%20Kenichiro&id=DOI:10.1007/s00062-023-01355-2 Name: Full Text Finder (for New FTF UI) (s8985755) Category: fullText Text: Find It @ SCU Libraries MouseOverText: Find It @ SCU Libraries |
|---|---|
| Header | DbId: edb DbLabel: Complementary Index An: 175567048 RelevancyScore: 1007 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 1007.03765869141 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Efficacy and Safety of Dual Antiplatelet Therapy with the Routine Use of Prasugrel for Flow Diversion of Cerebral Unruptured Aneurysms. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Suyama%2C+Kenichiro%22">Suyama, Kenichiro</searchLink><br /><searchLink fieldCode="AR" term="%22Nakahara%2C+Ichiro%22">Nakahara, Ichiro</searchLink><br /><searchLink fieldCode="AR" term="%22Matsumoto%2C+Shoji%22">Matsumoto, Shoji</searchLink><br /><searchLink fieldCode="AR" term="%22Morioka%2C+Jun%22">Morioka, Jun</searchLink><br /><searchLink fieldCode="AR" term="%22Tanabe%2C+Jun%22">Tanabe, Jun</searchLink><br /><searchLink fieldCode="AR" term="%22Hasebe%2C+Akiko%22">Hasebe, Akiko</searchLink><br /><searchLink fieldCode="AR" term="%22Watanabe%2C+Sadayoshi%22">Watanabe, Sadayoshi</searchLink> – Name: TitleSource Label: Source Group: Src Data: Clinical Neuroradiology; Mar2024, Vol. 34 Issue 1, p201-208, 8p – Name: Abstract Label: Abstract Group: Ab Data: Purpose: Prasugrel is not approved for patients treated with flow diverters, which have a high metal coverage ratio. However, robust antiplatelet therapy with prasugrel may prevent thromboembolic complications. We administered prasugrel and aspirin to all patients treated with flow diverters and reported the safety of the antiplatelet therapy regimen. Methods: This retrospective, single-center study evaluated the angiographic and clinical data of consecutive patients treated with flow diverters for cerebral unruptured aneurysms between June 2020 and May 2022. All patients received dual antiplatelet therapy, including prasugrel and aspirin. The administration of prasugrel ended 3 or 6 months after the procedure, whereas aspirin use continued for at least 12 months. Periprocedural complications (< 30 days post-procedure) and delayed complications (> 30 days post-procedure) were recorded. Results: During the study period, 120 unruptured aneurysms were treated with flow diverters in 110 patients. All patients, except one, survived longer than 12 months after the procedure. The rate of thromboembolic complications was 6.4%, and more than half of the patients had transient symptoms; one (0.9%) had a major ischemic stroke. One patient (0.9%) each had an asymptomatic, small subarachnoid hemorrhage and significant hemorrhagic complications with melena. The rate of permanent neurological deficits was 1.8%, and the mortality rate was 0.9%. Conclusions: Dual antiplatelet therapy comprising routine use of prasugrel and aspirin for flow diverter-implanted patients possibly contributed to a low rate of thromboembolic complications and low risk of hemorrhagic complications. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Clinical Neuroradiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edb&AN=175567048 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00062-023-01355-2 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 201 Titles: – TitleFull: Efficacy and Safety of Dual Antiplatelet Therapy with the Routine Use of Prasugrel for Flow Diversion of Cerebral Unruptured Aneurysms. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Suyama, Kenichiro – PersonEntity: Name: NameFull: Nakahara, Ichiro – PersonEntity: Name: NameFull: Matsumoto, Shoji – PersonEntity: Name: NameFull: Morioka, Jun – PersonEntity: Name: NameFull: Tanabe, Jun – PersonEntity: Name: NameFull: Hasebe, Akiko – PersonEntity: Name: NameFull: Watanabe, Sadayoshi IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 18691439 Numbering: – Type: volume Value: 34 – Type: issue Value: 1 Titles: – TitleFull: Clinical Neuroradiology Type: main |
| ResultId | 1 |