DNA methylation risk score for type 2 diabetes is associated with gestational diabetes.

Bibliographic Details
Title: DNA methylation risk score for type 2 diabetes is associated with gestational diabetes.
Authors: Linares-Pineda, Teresa M., Fragoso-Bargas, Nicolas, Picón, María José, Molina-Vega, Maria, Jenum, Anne Karen, Sletner, Line, Lee-Ødegård, Sindre, Opsahl, Julia O., Moen, Gunn-Helen, Qvigstad, Elisabeth, Prasad, Rashmi B., Birkeland, Kåre I., Morcillo, Sonsoles, Sommer, Christine
Source: Cardiovascular Diabetology; 2/13/2024, Vol. 23 Issue 1, p1-10, 10p
Abstract: Background: Gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) share many pathophysiological factors including genetics, but whether epigenetic marks are shared is unknown. We aimed to test whether a DNA methylation risk score (MRS) for T2DM was associated with GDM across ancestry and GDM criteria. Methods: In two independent pregnancy cohorts, EPIPREG (n = 480) and EPIDG (n = 32), DNA methylation in peripheral blood leukocytes was measured at a gestational age of 28 ± 2. We constructed an MRS in EPIPREG and EPIDG based on CpG hits from a published epigenome-wide association study (EWAS) of T2DM. Results: With mixed models logistic regression of EPIPREG and EPIDG, MRS for T2DM was associated with GDM: odd ratio (OR)[95% CI]: 1.3 [1.1–1.8], P = 0.002 for the unadjusted model, and 1.4 [1.1–1.7], P = 0.00014 for a model adjusted by age, pre-pregnant BMI, family history of diabetes and smoking status. Also, we found 6 CpGs through a meta-analysis (cg14020176, cg22650271, cg14870271, cg27243685, cg06378491, cg25130381) associated with GDM, and some of their methylation quantitative loci (mQTLs) were related to T2DM and GDM. Conclusion: For the first time, we show that DNA methylation marks for T2DM are also associated with GDM, suggesting shared epigenetic mechanisms between GDM and T2DM. [ABSTRACT FROM AUTHOR]
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Database: Complementary Index
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