Testosterone is positively associated with coronary artery calcium in a low cardiovascular disease risk population.
| Title: | Testosterone is positively associated with coronary artery calcium in a low cardiovascular disease risk population. |
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| Authors: | Trumble, Benjamin C, Negrey, Jacob, Koebele, Stephanie V, Thompson, Randall C, Wann, L Samuel, Allam, Adel H, Beheim, Bret, Sutherland, M Linda, Sutherland, James D, Rodriguez, Daniel Eid, Michalik, David E, Rowan, Chris J, Lombardi, Guido P, Garcia, Angela R, Cummings, Daniel K, Seabright, Edmond, Alami, Sarah, Kraft, Thomas S, Hooper, Paul, Buetow, Kenneth |
| Source: | Evolution, Medicine & Public Health; 2023, Vol. 11 Issue 1, p472-484, 13p |
| Subject Terms: | TESTOSTERONE, CORONARY artery bypass, CORONARY artery abnormalities, CALCIUM, CARDIOVASCULAR disease etiology |
| Abstract: | Background In industrialized populations, low male testosterone is associated with higher rates of cardiovascular mortality. However, coronary risk factors like obesity impact both testosterone and cardiovascular outcomes. Here, we assess the role of endogenous testosterone on coronary artery calcium in an active subsistence population with relatively low testosterone levels, low cardiovascular risk and low coronary artery calcium scores. Methodology In this cross-sectional community-based study, 719 Tsimane forager-horticulturalists in the Bolivian Amazon aged 40+ years underwent computed tomography (49.8% male, mean age 57.6 years). Results Coronary artery calcium levels were low; 84.5% had no coronary artery calcium. Zero-inflated negative binomial models found testosterone was positively associated with coronary artery calcium for the full sample (Incidence Rate Ratio [IRR] = 1.477, 95% Confidence Interval [CI] 1.001–2.170, P = 0.031), and in a male-only subset (IRR = 1.532, 95% CI 0.993–2.360, P = 0.053). Testosterone was also positively associated with clinically relevant coronary atherosclerosis (calcium >100 Agatston units) in the full sample (Odds Ratio [OR] = 1.984, 95% CI 1.202–3.275, P = 0.007) and when limited to male-only sample (OR = 2.032, 95% CI 1.118–4.816, P = 0.024). Individuals with coronary artery calcium >100 had 20% higher levels of testosterone than those with calcium <100 (t = –3.201, P = 0.007). Conclusions and Implications Among Tsimane, testosterone is positively associated with coronary artery calcium despite generally low normal testosterone levels, minimal atherosclerosis and rare cardiovascular disease (CVD) events. Associations between low testosterone and CVD events in industrialized populations are likely confounded by obesity and other lifestyle factors. [ABSTRACT FROM AUTHOR] |
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| Database: | Complementary Index |
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| Items | – Name: Title Label: Title Group: Ti Data: Testosterone is positively associated with coronary artery calcium in a low cardiovascular disease risk population. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Trumble%2C+Benjamin+C%22">Trumble, Benjamin C</searchLink><br /><searchLink fieldCode="AR" term="%22Negrey%2C+Jacob%22">Negrey, Jacob</searchLink><br /><searchLink fieldCode="AR" term="%22Koebele%2C+Stephanie+V%22">Koebele, Stephanie V</searchLink><br /><searchLink fieldCode="AR" term="%22Thompson%2C+Randall+C%22">Thompson, Randall C</searchLink><br /><searchLink fieldCode="AR" term="%22Wann%2C+L+Samuel%22">Wann, L Samuel</searchLink><br /><searchLink fieldCode="AR" term="%22Allam%2C+Adel+H%22">Allam, Adel H</searchLink><br /><searchLink fieldCode="AR" term="%22Beheim%2C+Bret%22">Beheim, Bret</searchLink><br /><searchLink fieldCode="AR" term="%22Sutherland%2C+M+Linda%22">Sutherland, M Linda</searchLink><br /><searchLink fieldCode="AR" term="%22Sutherland%2C+James+D%22">Sutherland, James D</searchLink><br /><searchLink fieldCode="AR" term="%22Rodriguez%2C+Daniel+Eid%22">Rodriguez, Daniel Eid</searchLink><br /><searchLink fieldCode="AR" term="%22Michalik%2C+David+E%22">Michalik, David E</searchLink><br /><searchLink fieldCode="AR" term="%22Rowan%2C+Chris+J%22">Rowan, Chris J</searchLink><br /><searchLink fieldCode="AR" term="%22Lombardi%2C+Guido+P%22">Lombardi, Guido P</searchLink><br /><searchLink fieldCode="AR" term="%22Garcia%2C+Angela+R%22">Garcia, Angela R</searchLink><br /><searchLink fieldCode="AR" term="%22Cummings%2C+Daniel+K%22">Cummings, Daniel K</searchLink><br /><searchLink fieldCode="AR" term="%22Seabright%2C+Edmond%22">Seabright, Edmond</searchLink><br /><searchLink fieldCode="AR" term="%22Alami%2C+Sarah%22">Alami, Sarah</searchLink><br /><searchLink fieldCode="AR" term="%22Kraft%2C+Thomas+S%22">Kraft, Thomas S</searchLink><br /><searchLink fieldCode="AR" term="%22Hooper%2C+Paul%22">Hooper, Paul</searchLink><br /><searchLink fieldCode="AR" term="%22Buetow%2C+Kenneth%22">Buetow, Kenneth</searchLink> – Name: TitleSource Label: Source Group: Src Data: Evolution, Medicine & Public Health; 2023, Vol. 11 Issue 1, p472-484, 13p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22TESTOSTERONE%22">TESTOSTERONE</searchLink><br /><searchLink fieldCode="DE" term="%22CORONARY+artery+bypass%22">CORONARY artery bypass</searchLink><br /><searchLink fieldCode="DE" term="%22CORONARY+artery+abnormalities%22">CORONARY artery abnormalities</searchLink><br /><searchLink fieldCode="DE" term="%22CALCIUM%22">CALCIUM</searchLink><br /><searchLink fieldCode="DE" term="%22CARDIOVASCULAR+disease+etiology%22">CARDIOVASCULAR disease etiology</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background In industrialized populations, low male testosterone is associated with higher rates of cardiovascular mortality. However, coronary risk factors like obesity impact both testosterone and cardiovascular outcomes. Here, we assess the role of endogenous testosterone on coronary artery calcium in an active subsistence population with relatively low testosterone levels, low cardiovascular risk and low coronary artery calcium scores. Methodology In this cross-sectional community-based study, 719 Tsimane forager-horticulturalists in the Bolivian Amazon aged 40+ years underwent computed tomography (49.8% male, mean age 57.6 years). Results Coronary artery calcium levels were low; 84.5% had no coronary artery calcium. Zero-inflated negative binomial models found testosterone was positively associated with coronary artery calcium for the full sample (Incidence Rate Ratio [IRR] = 1.477, 95% Confidence Interval [CI] 1.001–2.170, P = 0.031), and in a male-only subset (IRR = 1.532, 95% CI 0.993–2.360, P = 0.053). Testosterone was also positively associated with clinically relevant coronary atherosclerosis (calcium >100 Agatston units) in the full sample (Odds Ratio [OR] = 1.984, 95% CI 1.202–3.275, P = 0.007) and when limited to male-only sample (OR = 2.032, 95% CI 1.118–4.816, P = 0.024). Individuals with coronary artery calcium >100 had 20% higher levels of testosterone than those with calcium <100 (t = –3.201, P = 0.007). Conclusions and Implications Among Tsimane, testosterone is positively associated with coronary artery calcium despite generally low normal testosterone levels, minimal atherosclerosis and rare cardiovascular disease (CVD) events. Associations between low testosterone and CVD events in industrialized populations are likely confounded by obesity and other lifestyle factors. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Evolution, Medicine & Public Health is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1093/emph/eoad039 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 472 Subjects: – SubjectFull: TESTOSTERONE Type: general – SubjectFull: CORONARY artery bypass Type: general – SubjectFull: CORONARY artery abnormalities Type: general – SubjectFull: CALCIUM Type: general – SubjectFull: CARDIOVASCULAR disease etiology Type: general Titles: – TitleFull: Testosterone is positively associated with coronary artery calcium in a low cardiovascular disease risk population. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Trumble, Benjamin C – PersonEntity: Name: NameFull: Negrey, Jacob – PersonEntity: Name: NameFull: Koebele, Stephanie V – PersonEntity: Name: NameFull: Thompson, Randall C – PersonEntity: Name: NameFull: Wann, L Samuel – PersonEntity: Name: NameFull: Allam, Adel H – PersonEntity: Name: NameFull: Beheim, Bret – PersonEntity: Name: NameFull: Sutherland, M Linda – PersonEntity: Name: NameFull: Sutherland, James D – PersonEntity: Name: NameFull: Rodriguez, Daniel Eid – PersonEntity: Name: NameFull: Michalik, David E – PersonEntity: Name: NameFull: Rowan, Chris J – PersonEntity: Name: NameFull: Lombardi, Guido P – PersonEntity: Name: NameFull: Garcia, Angela R – PersonEntity: Name: NameFull: Cummings, Daniel K – PersonEntity: Name: NameFull: Seabright, Edmond – PersonEntity: Name: NameFull: Alami, Sarah – PersonEntity: Name: NameFull: Kraft, Thomas S – PersonEntity: Name: NameFull: Hooper, Paul – PersonEntity: Name: NameFull: Buetow, Kenneth IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: 2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 20506201 Numbering: – Type: volume Value: 11 – Type: issue Value: 1 Titles: – TitleFull: Evolution, Medicine & Public Health Type: main |
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